Diagnostic Performance of Macular Ganglion Cell/Inner Plexiform Layer Thickness to Discriminate Normal Eye from Eye with Early Glaucoma Using Cirrus Spectral-Domain Optical Coherence Tomography

2019 ◽  
Vol 43 (1) ◽  
pp. 7
Author(s):  
Widya Artini ◽  
Baltazar Bimo Bisara
Keyword(s):  
Ganglion Cell ◽  
Optic Neuropathy ◽  
Diagnostic Performance ◽  
Ganglion Cells ◽  
Plexiform Layer ◽  
Spectral Domain ◽  
Reference List ◽  
Search Term ◽  
Inner Plexiform Layer ◽  
Early Glaucoma

Background: Glaucoma is a progressive optic neuropathy characterized by a progressive loss of retinal ganglion cells (RGC). In glaucomatous optic neuropathy, structural optic nerve changes may occur before detectable functional loss, which can be diagnosed early by detecting loss of RGC. This review was conducted to see the diagnostic performance of macular ganglion cell/inner plexiform layer (GC-IPL) thickness parameters to discriminate normal eye from early glaucoma eye using Cirrus Spectral-domain OCT compared to peri-papilarry Retinal Nerve Fiber Layer (RNFL) thickness parameters. Methods: Literature search was conducted from MEDLINE database using Pubmed, Clinical Key, and ScienceDirect. No publication date was set, and only articles published in English were included. Reference list from the included studies were also checked for potentially relevant articles. Results: Twenty articles were found related to search term. Seven articles met the inclusion criteria. Fourteen others were excluded. All studies revealed significant thinner GC-IPL and RNFL average thickness in glaucoma patients compared to normal patients. GC-IPL Average was inferior to GC-IPL Minimum and RNFL inferior in determining normal eye from early glaucomatous eyes. Studies evaluating the diagnostic performance of Ganglion Cells Complex (GCC) thickness also found low sensitivity values, ranging between 61.0% and 78.6% for average GCC. Conclusion: Diagnostic performance of GC-IPL is comparable to RNFL parameters measurement in detecting early glaucoma eyes. Best performance in detecting early glaucoma were showed by GC-IPL minimum and RNFL inferior.

scholarly journals Diagnostic Performance of Optical Coherence Tomography Ganglion Cell–Inner Plexiform Layer Thickness Measurements in Early Glaucoma

Ophthalmology ◽  
2014 ◽  
Vol 121 (4) ◽  
pp. 849-854 ◽  
Author(s):  
Jean-Claude Mwanza ◽  
Donald L. Budenz ◽  
David G. Godfrey ◽  
Arvind Neelakantan ◽  
Fouad E. Sayyad ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Layer Thickness ◽  
Diagnostic Performance ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Early Glaucoma ◽  
Thickness Measurements

Development of cholinergic amacrine cell stratification in the ferret retina and the effects of early excitotoxic ablation

2001 ◽  
Vol 18 (4) ◽  
pp. 559-570 ◽  
Author(s):  
B.E. REESE ◽  
M.A. RAVEN ◽  
K.A. GIANNOTTI ◽  
P.T. JOHNSON
Keyword(s):  
Ganglion Cell ◽  
Ganglion Cells ◽  
Plexiform Layer ◽  
Amacrine Cells ◽  
Cell Types ◽  
Retinal Cell ◽  
Inner Plexiform Layer ◽  
Retinal Ganglion ◽  
Outer Border ◽  
Cholinergic Amacrine Cells

The present study has examined the emergence of cholinergic stratification within the developing inner plexiform layer (IPL), and the effect of ablating the cholinergic amacrine cells on the formation of other stratifications within the IPL. The population of cholinergic amacrine cells in the ferret's retina was identified as early as the day of birth, but their processes did not form discrete strata until the end of the first postnatal week. As development proceeded over the next five postnatal weeks, so the positioning of the cholinergic strata shifted within the IPL toward the outer border, indicative of the greater ingrowth and elaboration of processes within the innermost parts of the IPL. To examine whether these cholinergic strata play an instructive role upon the development of other stratifications which form within the IPL, one-week-old ferrets were treated with l-glutamate in an attempt to ablate the population of cholinergic amacrine cells. Such treatment was shown to be successful, eliminating all of the cholinergic amacrine cells as well as the alpha retinal ganglion cells in the central retina. The remaining ganglion cell classes as well as a few other retinal cell types were partially reduced, while other cell types were not affected, and neither retinal histology nor areal growth was compromised in these ferrets. Despite this early loss of the cholinergic amacrine cells, which are eliminated within 24 h, other stratifications within the IPL formed normally, as they do following early elimination of the entire ganglion cell population. While these cholinergic amacrine cells are present well before other cell types have differentiated, apparently neither they, nor the ganglion cells, play a role in determining the depth of stratification for other retinal cell types.

Diagnostic value of ganglion cell-inner plexiform layer for early detection of ethambutol-induced optic neuropathy

2018 ◽  
Vol 103 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Ju-Yeun Lee ◽  
Jinu Han ◽  
Jeong Gi Seo ◽  
Kyung-Ah Park ◽  
Sei Yeul Oh
Keyword(s):  
Early Detection ◽  
Ganglion Cell ◽  
Optic Neuropathy ◽  
Plexiform Layer ◽  
Diagnostic Value ◽  
Retinal Nerve Fibre Layer ◽  
Field Pattern ◽  
Control Group ◽  
Inner Plexiform Layer ◽  
Minimum Thickness

AimTo evaluate the diagnostic value of macular ganglion cell-inner plexiform layer (mGCIPL) thickness versus peripapillary retinal nerve fibre layer (pRNFL) thickness for the early detection of ethambutol-induced optic neuropathy (EON).MethodsTwenty-eight eyes of 15 patients in the EON group and 100 eyes of 53 healthy subjects in the control group were included. All patients with EON demonstrated the onset of visual symptoms within 3 weeks. Diagnostic power for pRNFL and mGCIPL thicknesses measured by Cirrus spectral-domain optical coherence tomography was assessed by area under the receiver operating characteristic (AUROC) curves and sensitivity.ResultsAll of the mGCIPL thickness measurements were thinner in the EON group than in the control group in early EON (p<0.001). All of pRNFL thicknesses except inferior RNFL showed AUROC curves above 0.5, and all of the mGCIPL thicknesses showed AUROC curves above 0.5. The AUROC of the average mGCIPL (0.812) thickness was significantly greater than that of the average pRNFL (0.507) thickness (p<0.001). Of all the mGCIPL-related parameters considered, the minimum thickness showed the greatest AUROC value (0.863). The average mGCIPL thickness showed a weak correlation with visual field pattern standard deviations (r2=0.158, p<0.001).ConclusionsIn challenging cases of EON, the mGCIPL thickness has better diagnostic performance in detecting early-onset EON as compared with using pRNFL thickness. Among the early detection ability of mGCIPL thickness, minimum GCIPL thickness has high diagnostic ability.

Regional distribution of nitrergic neurons in the inner retina of the chicken

2011 ◽  
Vol 28 (3) ◽  
pp. 205-220 ◽  
Author(s):  
MARTIN WILSON ◽  
NICK NACSA ◽  
NATHAN S. HART ◽  
CYNTHIA WELLER ◽  
DAVID I. VANEY
Keyword(s):  
Ganglion Cell ◽  
Ganglion Cells ◽  
Regional Distribution ◽  
Plexiform Layer ◽  
Visual Image ◽  
Amacrine Cells ◽  
Cell Types ◽  
Inner Plexiform Layer ◽  
Inner Retina ◽  
Neuronal Types

AbstractUsing both NADPH diaphorase and anti-nNOS antibodies, we have identified—from retinal flatmounts—neuronal types in the inner retina of the chicken that are likely to be nitrergic. The two methods gave similar results and yielded a total of 15 types of neurons, comprising 9 amacrine cells, 5 ganglion cells, and 1 centrifugal midbrain neuron. Six of these 15 cell types are ubiquitously distributed, comprising 3 amacrine cells, 2 displaced ganglion cells, and a presumed orthotopic ganglion cell. The remaining nine cell types are regionally restricted within the retina. As previously reported, efferent fibers of midbrain neurons and their postsynaptic partners, the unusual axon-bearing target amacrine cells, are entirely confined to the ventral retina. Also confined to the ventral retina, though with somewhat different distributions, are the “bullwhip” amacrine cells thought to be involved in eye growth, an orthotopic ganglion cell, and two types of large axon-bearing amacrine cells whose dendrites and axons lie in stratum 1 of the inner plexiform layer (IPL). Intracellular fills of these two cell types showed that only a minority of otherwise morphologically indistinguishable neurons are nitrergic. Two amacrine cells that branch throughout the IPL are confined to an equatorial band, and one small-field orthotopic ganglion cell that branches in the proximal IPL is entirely dorsal. These findings suggest that the retina uses different processing on different regions of the visual image, though the benefit of this is presently obscure.

Sign in / Sign up

Export Citation Format

Share Document