A CASE SIMULATING INTRACRANIAL TUMOUR: IN WHICH RECOVERY WAS ASSOCIATED WITH PERSISTENT CEREBRO-SPINAL RHINORRHOEA

BACKGROUND: Primary Central nervous system tumours occupies less than 2% of overall human cancers in adults. The accurate diagnosis of intracranial tumour is necessary for therapeutic and prognostic purpose. Intraoperative smear cytology provides a rapid diagnosis which helps the neurosurgeon for immediate decision regarding the extent of surgery. To Objectives: determine the accuracy of squash preparation, by comparing it with histopathological sections and analysing the cytomorphological features of astrocytoma This was both retrospective and prospective study. We receive Methods: d nineteen radiologically and clinically suspected Astrocytoma in saline with xatives. Crush smear were made and stained with rapid Haematoxylin and Eosin. The corresponding biopsy materials were xed in 10% neutral buffered formalin and submitted for tissue processing. Staining was done with routine Haematoxylin and Eosin stain. The cytomorphologicalfeatures of these tumours were correlated with histopathological sections. In our study, we received Results: nineteen radiologically and clinically suspected Astrocytoma , tissue of all the tumours were soft and easy to smear . Glioblastomamultiforme was the most commonly encounterd tumor amomgneuroepithelial tumor constituting about 42.1% followed by diffuse astrocytoma (36.8%), WHOgrade II and IV tumors of astrocytoma were commonly encountered in ourstudy. Astrocytoma was common in males than females with majority of them fall in 5 th decade. we got 94.7% correlation between squash cytology and histopathology. Squash cytology is Conclusion: simple,rapid, accurate and cost effective diagnostic tool for Astrocytoma

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Presentations to An Acute Medical Unit Due to Headache: A Review of 306 Consecutive Cases

Acute Medicine Journal ◽

10.52964/amja.0563 ◽

2012 ◽

Vol 11 (3) ◽

pp. 144-150

Author(s):

James Knox ◽

◽

Chandini Chuni ◽

Zehra Naqvi ◽

Pam Crawford ◽

...

Keyword(s):

National Health Service ◽

Health Service ◽

Ambulatory Care ◽

Significant Proportion ◽

Care Pathways ◽

Intracranial Tumour ◽

Medical Unit ◽

Acute Medical Unit ◽

The United Kingdom ◽

Acute Headache

The United Kingdom National Health Service has recently prioritised the need for ambulatory care pathways for acute headache. The present study sought to better characterise patients referred to an Acute Medical Unit so as to inform pathway development. In 2011, York Hospital received 306 referrals due to acute headache, representing 3% of acute medical admissions. Investigations included CT scan (38%), lumbar puncture (38%), and MRI (18%); there were no specialised investigations in 26%, and 18% of patients were discharged on the day of presentation. Subarachnoid haemorrhage occurred in only 4 patients (1%), meningitis in 10 (3%), and intracranial tumour in 5 (2%). The findings indicate that a significant proportion of patients with acute headache could be managed by ambulatory care.

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The Potential Benefit by Application of Kinetic Analysis of PET in the Clinical Oncology

ISRN Oncology ◽

10.5402/2012/349351 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Mustafa Takesh

Keyword(s):

Kinetic Analysis ◽

Pet Imaging ◽

Therapy Monitoring ◽

Malignant Lesion ◽

Visual Assessment ◽

Lung Tumour ◽

Potential Contribution ◽

Intracranial Tumour ◽

Target Tissue ◽

Colorectal Tumour

PET is an appropriate method to display the functional activities in target tissue using many types of traces. The visual assessment of PET images plus the semiquantitative parameter (SUV) are the main diagnostic standards considered in identifying the malignant lesion. However, these standards lack occasionally the proper specificity and/or sensitivity. That emphasizes the importance of considering supplemental diagnostic criteria such as the kinetic parameter. The latter gives the way to image the ongoing metabolic processes within the target tissue as well as to identify the alterations occurring at the microscale level before they become observable in the conventional PET-imaging. The importance of kinetic analysis of PET imaging has increased with newly developed PET devices that offer images of good quality and high spatial resolution. In this paper, we highlighted the potential contribution of kinetic analysis in improving the diagnostic accuracy in intracranial tumour, lung tumour, liver tumour, colorectal tumour, bone and soft tissue tumours, and prostate cancer. Moreover, we showed that the appropriate therapy monitoring can be best achieved after considering the kinetic parameters. These promising results indicate that the kinetic analysis of PET imaging may become an essential part in preclinical and clinical molecular imaging as well.

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Endoscopic resection of intracranial dermoid cysts

The Journal of Laryngology & Otology ◽

10.1017/s0022215110002823 ◽

2011 ◽

Vol 125 (4) ◽

pp. 423-427 ◽

Cited By ~ 19

Author(s):

D Schuster ◽

K O Riley ◽

J K Cure ◽

B A Woodworth

Keyword(s):

Skull Base ◽

Endoscopic Resection ◽

Case Reports ◽

Complete Resection ◽

Intracranial Tumour ◽

Traditional Treatment ◽

Tumour Removal ◽

Skull Base Approach ◽

Transnasal Endoscopic Approach ◽

Skull Base Defect

AbstractIntroduction:Nasal dermoid cysts are congenital lesions which are often diagnosed in infancy or childhood. However, a small number present in adulthood, and some extend intracranially. Traditional treatment for the intracranial portion of these cysts includes frontal craniotomy.Case reports:Two intracranial dermoid cysts were resected via a transnasal endoscopic approach, using 70° nasal endoscopy for complete visualisation and intracranial tumour removal. We describe our technique for the procedure itself and for reconstruction of the skull base defect.Discussion and conclusion:The endoscopic transnasal skull base approach is an excellent alternative to a traditional frontal craniotomy, to achieve complete resection of intracranial dermoid cysts.

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FP2-3 Ten years of paediatric neuro-oncology surgery: quantifying and predicting complications after surgery for intracranial tumour excision

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2019-abn.81 ◽

2019 ◽

Vol 90 (3) ◽

pp. e26.1-e26

Author(s):

MT Foster ◽

R Grayston ◽

D Hennigan ◽

LS Harishchandra ◽

LV Tonder ◽

...

Keyword(s):

Perioperative Complications ◽

Intracranial Tumour ◽

Surgical Morbidity ◽

Who Grade ◽

Age At Surgery ◽

Grading Scale ◽

Insight Into ◽

Scale Data ◽

Who Grade Iii ◽

Grade Iii

ObjectivesTo measure complications of paediatric neurooncology surgery using the Clavien Dindo grading scale, and identify predictors of surgical morbidity.DesignRetrospective review of prospectively collected data.SubjectsAll paediatric patients treated with craniotomy for excision of intracranial tumour between 2008 and 2017 in a single tertiary paediatric neurosurgery centre.MethodsDemographics, surgical details and perioperative complications were prospectively recorded between 0 and 30 days post operatively. These were retrospectively graded using the CD scale. Data analysis was done in R using logistic regression. Significance was defined as p<0.05ResultsBetween 3/1/2008 and 21/12/2017 there were 322 operations, on 254 patients (142 Male). Median age at surgery was 9 years (IQR 4–13 years). 48% were without complication on the CD scale. Maximum CD grade complication for each procedure was 1 in 11%, 2 in 19%, 3A in 2%, 3B in 14%, and 4 in 0.6% of operations. 30 day mortality was 0.9%. CD grade of 3B or over was associated with infratentorial tumours (OR 2.24; CI 1.10–4.68; p=0.004) and WHO grade III tumours (OR 4.12; CI 1.56–10.86; p=0.028).ConclusionsComplications in paediatric neurooncology surgery are common overall, but our results are favourable in comparison to the literature. The CD scale has limitations in neurosurgery but gives insight into the health economic impact of complications. Infratentorial tumours, and WHO grade III tumours were associated with increased morbidity.

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Assessment of heart rate variability during different propofol effect site concentrations in patients with supratentorial tumours: A pilot study

Journal of Neuroanaesthesiology and Critical Care ◽

10.4103/jnacc-jnacc-4.17 ◽

2017 ◽

Vol 04 (02) ◽

pp. 108-113

Author(s):

Mohit Mittal ◽

Radhakrishnan Muthuchellappan ◽

G. Umamaheswara Rao ◽

K. Kavyashree ◽

K. Vishnuprasad

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Total Power ◽

Control Group ◽

Baseline Heart Rate ◽

Study Group ◽

Intracranial Tumour ◽

Anaesthetic Induction ◽

Effect Site ◽

Supratentorial Tumours

Abstract Background: Impaired autonomic function (AF) can result in adverse cardiovascular events during the perioperative period. Literature suggests that patients with intracranial space-occupying lesions experience impaired AF depending on the site of tumour and associated raised intracranial pressure (ICP). The complex interaction between general anaesthetics, AF and intracranial tumours with raised ICP has not been extensively studied. Objective: This study was aimed at evaluating the cardiac AF (in terms of heart rate variability [HRV]) in patients undergoing surgery for supratentorial tumours, at baseline and at different propofol effect site concentrations (Ce) during anaesthetic induction and the results were compared with patients undergoing non-cranial surgeries. Materials and Methods: In this prospective observational study, consecutive adult patients undergoing surgeries for supratentorial tumour (study group) and brachial plexus injury (control group) were recruited. Electrocardiogram was recorded for 5 min at three time points – before propofol induction, at propofol Ce 2 μg/ml and at Ce 4 μg/ml. Results: Forty-five patients were recruited, 24 in study group and 21 in control group. In spite of similar baseline heart rate and blood pressure, low frequency (LF), high frequency (HF) and total power were significantly higher in control group. Baseline LF/HF, though higher in patients with intracranial tumour (craniotomy: 2.2 ± 2.2, control: 1.2 ± 1.1), was not significantly different between the two groups (P = 0.197). HRV variables in both the groups changed the same way in response to the increasing propofol Ce. Conclusion: HRV measurements were significantly different at baseline between the two groups. Following propofol administration, haemodynamic changes and HRV changes were similar in both the groups and also between the two groups.

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