scholarly journals Temporal relation between depression and cognitive impairment in old age: prospective population based study

BMJ ◽  
2004 ◽  
Vol 329 (7471) ◽  
pp. 881 ◽  
Author(s):  
David J Vinkers ◽  
Jacobijn Gussekloo ◽  
Max L Stek ◽  
Rudi G J Westendorp ◽  
Roos C van der Mast
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Cognitive Decline ◽  
Old Age ◽  
Depression Scale ◽  
Population Based ◽  
Temporal Relation ◽  
Population Based Study ◽  
Delayed Recall

Abstract Objective To examine the temporal relation between depression and cognitive impairment in old age. Design Prospective, population based study with four years of follow up. Setting City of Leiden, the Netherlands. Participants 500 people aged 85 years at recruitment. Main outcome measures Annual assessments of depressive symptoms (15 item geriatric depression scale), global cognitive function (mini-mental state examination), attention (Stroop test), processing speed (letter digit coding test), and immediate and delayed recall (12 word learning test). Results At 85 years old, participants' depressive symptoms and cognitive impairment were highly significantly correlated (P < 0.001). During follow up, an accelerated annual increase of depressive symptoms was associated with impaired attention (0.08 points (95% confidence interval 0.01 to 0.16)), immediate recall (0.17 points (0.09 to 0.25)), and delayed recall (0.10 points (0.02 to 0.18)) at baseline. In contrast, depressive symptoms at baseline were not related to an accelerated cognitive decline during follow up (P > 0.05). Conclusion Caregivers should be aware of the development of depressive symptoms when cognitive impairment is present. However, the presence of depression only does not increase the risk of cognitive decline.

scholarly journals Ginkgo Biloba Extract and Long-Term Cognitive Decline: A 20-Year Follow-Up Population-Based Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e52755 ◽  
Author(s):  
Hélène Amieva ◽  
Céline Meillon ◽  
Catherine Helmer ◽  
Pascale Barberger-Gateau ◽  
Jean François Dartigues
Keyword(s):  
Cognitive Decline ◽  
Ginkgo Biloba ◽  
Population Based ◽  
Ginkgo Biloba Extract ◽  
Population Based Study

scholarly journals Depressive symptoms and cognitive decline in elderly people

2002 ◽  
Vol 181 (5) ◽  
pp. 406-410 ◽  
Author(s):  
Sabrina Paterniti ◽  
Marie-Hélène Verdier-Taillefer ◽  
Carole Dufouil ◽  
Annick Alpérovitch
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Decline ◽  
Elderly People ◽  
Depressive Symptomatology ◽  
Mmse Score ◽  
Epidemiologic Study ◽  
Depression Scale ◽  
Depressive Episodes ◽  
State Examination

BackgroundDepressive symptoms are associated with cognitive decline in elderly people, but the nature of their temporal relationship remains equivocal.AimsTo test whether depressive symptoms predict cognitive decline in elderly people with normal cognition.MethodThe Center for Epidemiologic Study depression scale (CES – D) and the Mini-Mental State Examination (MMSE) were used to evaluate depressive symptomatology and cognitive functioning, respectively. A sample of 1003 persons aged 59–71 years and with a MMSE score of 26 or over was selected. Cognitive decline was defined as a drop of at least 3 points on the MMSE at 4-year follow-up.ResultsBaseline high levels of depressive symptoms predicted a higher risk of cognitive decline at 4-year follow-up. The MMSE score of participants with depression was more likely to fall below 26 at 2-year follow-up and to remain below at 4-year follow-up than the MMSE score of those without depressive symptoms. Persistent but not episodic depressive episodes were associated with cognitive decline.ConclusionsHigh levels of depressive symptoms, when persistent, are associated with cognitive decline in a sample of elderly people.

Depressive Symptoms Predict Cognitive Decline in an Elderly Non Disabled Population with White Matter Changes. Results of the LADIS Study

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
A. Verdelho ◽  
S. Madureira ◽  
C. Moleiro ◽  
J.M. Ferro
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
White Matter ◽  
Cognitive Decline ◽  
Elderly Population ◽  
Depression Scale ◽  
Elderly Subjects ◽  
White Matter Changes ◽  
The Impact ◽  
Independent Elderly

Aims:Depressive symptoms (DS) in the elderly have been implicated in cognitive decline, and are more frequent in patients with white matter changes (WMC). Our aim was to ascertain if DS influence cognition in an elderly population with WMC.Methods:The LADIS (Leukoaraiosis and Disability) is a prospective European study that evaluates the impact of WMC on the transition of independent elderly subjects into disability. Subjects were enrolled due to minor complaints without impact in daily-living activities, and presence of WMC. Subjects were evaluated at baseline and yearly during 3 years with a comprehensive clinical and functional protocol. DS were recorded with the Geriatric Depression Scale (GDS). Major depression was classified according to the DSM-IV criteria. Dementia and cognitive decline not dementia were diagnosed according to usual clinical criteria. MRI was performed at entry and at the end of the study. WMC severity was rated according to the Fazeka's scale.Results:639 subjects were included (74.1 ± 5 years old, 55% women, 9.6±3.8 years of schooling). 89% (568), 78.4% (501), and 75% (480) of the patients from the initial sample were followed-up in clinical visit at year 1, 2 and 3. At the end of the study 90 patients were demented and 147 patients had cognitive impairment not dementia. Using survival Cox regression we found that depressive symptoms were independent predictors of cognitive impairment independently of age, education, gender, WMC severity and temporal atrophy.Conclusion:Depressive symptoms are independent predictor of cognitive decline in an independent elderly population with WMC.

DT-02-06: Middle age protective score based on self-reported measures predicts dementia status in old age: A population-based study with 28-year follow-up

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P335-P335
Author(s):  
Eero Vuoksimaa ◽  
Kauko Heikkilä ◽  
Markku Koskenvuo ◽  
Juha O. Rinne ◽  
Jaakko Kaprio
Keyword(s):  
Old Age ◽  
Middle Age ◽  
Population Based ◽  
Population Based Study

O1-04-05: Hypertension, APOE-ɛ4 allele, regional white-matter hyperintensities, and cognitive decline in old age: A population-based study

2015 ◽  
Vol 11 (7S_Part_3) ◽  
pp. P134-P134
Author(s):  
Chengxuan Qiu ◽  
Anna Laveskog ◽  
Rui Wang ◽  
Lena Bronge ◽  
Lars-Olof Wahlund ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Old Age ◽  
White Matter Hyperintensities ◽  
Population Based ◽  
Population Based Study ◽  
E4 Allele

P1-020: Structural brain changes mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P344-P344
Author(s):  
Rui Wang ◽  
Laura Fratiglioni ◽  
Grégoria Kalpouzos ◽  
Martin Lövdén ◽  
Erika Jonsson Laukka ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cognitive Decline ◽  
Old Age ◽  
Population Based ◽  
Population Based Study ◽  
Brain Changes ◽  
Structural Brain

scholarly journals P2-551: MIGRAINE, COGNITIVE DECLINE, AND DEMENTIA IN OLD AGE: A POPULATION-BASED STUDY

2019 ◽  
Vol 15 ◽  
pp. P832-P832
Author(s):  
Ya Gao ◽  
Rui Wang ◽  
Yajun Liang ◽  
Giulia Grande ◽  
Roberto Monastero ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Old Age ◽  
Population Based ◽  
Population Based Study

scholarly journals Investigating Sequential and Simultaneous Changes in Trajectories of Cognitive Decline and Depressive Symptoms

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 75-75
Author(s):  
Matthias Klee ◽  
Anja Leist
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Decline ◽  
Employment Status ◽  
Depression Scale ◽  
Memory Recall ◽  
Delayed Recall ◽  
Early Symptom ◽  
Co Morbidity ◽  
Logistic Regressions

Abstract Background. The role of depression as risk factor or early symptom of cognitive decline and dementia is still debated. Exploiting longitudinal trajectories of memory recall in a large European sample, we sought to better understand the nature of simultaneous versus sequential changes in depressive symptoms alongside memory recall at older ages. Method. A total of 4,865 respondents to the SHARE survey, mean age at t1 61.5 years (SD = 7.53), completed the EURO-D depression scale and a delayed recall task across six waves spanning ~13 years. We applied k-means clustering to distinguish trajectories of depressive symptoms and delayed recall. Clusters indicating depressive and recall trajectories were included in logistic regressions to assess likelihood of parallel versus sequential change, controlling for age, gender, employment status and education. Results. Analyses revealed six distinct trajectories each for depressive symptoms and delayed recall. Visual inspections indicated that only declining recall trajectories showed increases in depressive symptoms, occurring simultaneously rather than sequentially. Using grouped declining recall trajectories as outcome, the low-increasing depressive symptoms trajectory was associated with cognitive decline (OR = 1.52 [1.11, 2.06]), whereas the stable-high depressive symptoms trajectory was associated with cognitive decline in respondents aged 60-69 years (OR = 1.78 [1.01, 3.16]). Discussion. Distinguishing trajectories in depression and recall incorporates longitudinal information able to further elucidate relationships between depression and cognition. While the findings suggest depression as a co-morbidity, attention needs to be given to a comparatively small high-stable depressive symptoms trajectory group with elevated risk of cognitive decline in their 60s.

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