Depressive Symptoms Predict Cognitive Decline in an Elderly Non Disabled Population with White Matter Changes. Results of the LADIS Study

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
A. Verdelho ◽  
S. Madureira ◽  
C. Moleiro ◽  
J.M. Ferro
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
White Matter ◽  
Cognitive Decline ◽  
Elderly Population ◽  
Depression Scale ◽  
Elderly Subjects ◽  
White Matter Changes ◽  
The Impact ◽  
Independent Elderly

Aims:Depressive symptoms (DS) in the elderly have been implicated in cognitive decline, and are more frequent in patients with white matter changes (WMC). Our aim was to ascertain if DS influence cognition in an elderly population with WMC.Methods:The LADIS (Leukoaraiosis and Disability) is a prospective European study that evaluates the impact of WMC on the transition of independent elderly subjects into disability. Subjects were enrolled due to minor complaints without impact in daily-living activities, and presence of WMC. Subjects were evaluated at baseline and yearly during 3 years with a comprehensive clinical and functional protocol. DS were recorded with the Geriatric Depression Scale (GDS). Major depression was classified according to the DSM-IV criteria. Dementia and cognitive decline not dementia were diagnosed according to usual clinical criteria. MRI was performed at entry and at the end of the study. WMC severity was rated according to the Fazeka's scale.Results:639 subjects were included (74.1 ± 5 years old, 55% women, 9.6±3.8 years of schooling). 89% (568), 78.4% (501), and 75% (480) of the patients from the initial sample were followed-up in clinical visit at year 1, 2 and 3. At the end of the study 90 patients were demented and 147 patients had cognitive impairment not dementia. Using survival Cox regression we found that depressive symptoms were independent predictors of cognitive impairment independently of age, education, gender, WMC severity and temporal atrophy.Conclusion:Depressive symptoms are independent predictor of cognitive decline in an independent elderly population with WMC.

O2-02-06: Depressive symptoms predict cognitive impairment in nondisabled elderly with white matter changes: The LADIS study

2009 ◽  
Vol 5 (4S_Part_4) ◽  
pp. P105-P106
Author(s):  
Ana Verdelho ◽  
Sofia Madureira ◽  
Carla Moleiro ◽  
Jose M. Ferro ◽  
John O'Brien ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
White Matter ◽  
White Matter Changes

scholarly journals Temporal relation between depression and cognitive impairment in old age: prospective population based study

BMJ ◽  
2004 ◽  
Vol 329 (7471) ◽  
pp. 881 ◽  
Author(s):  
David J Vinkers ◽  
Jacobijn Gussekloo ◽  
Max L Stek ◽  
Rudi G J Westendorp ◽  
Roos C van der Mast
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Cognitive Decline ◽  
Old Age ◽  
Depression Scale ◽  
Population Based ◽  
Temporal Relation ◽  
Population Based Study ◽  
Delayed Recall

Abstract Objective To examine the temporal relation between depression and cognitive impairment in old age. Design Prospective, population based study with four years of follow up. Setting City of Leiden, the Netherlands. Participants 500 people aged 85 years at recruitment. Main outcome measures Annual assessments of depressive symptoms (15 item geriatric depression scale), global cognitive function (mini-mental state examination), attention (Stroop test), processing speed (letter digit coding test), and immediate and delayed recall (12 word learning test). Results At 85 years old, participants' depressive symptoms and cognitive impairment were highly significantly correlated (P < 0.001). During follow up, an accelerated annual increase of depressive symptoms was associated with impaired attention (0.08 points (95% confidence interval 0.01 to 0.16)), immediate recall (0.17 points (0.09 to 0.25)), and delayed recall (0.10 points (0.02 to 0.18)) at baseline. In contrast, depressive symptoms at baseline were not related to an accelerated cognitive decline during follow up (P > 0.05). Conclusion Caregivers should be aware of the development of depressive symptoms when cognitive impairment is present. However, the presence of depression only does not increase the risk of cognitive decline.

scholarly journals Cognitive training in older adults with Mild Cognitive Impairment: Impact on cognitive and functional performance

2009 ◽  
Vol 3 (2) ◽  
pp. 124-131 ◽  
Author(s):  
Paula Schimidt Brum ◽  
Orestes Vicente Forlenza ◽  
Mônica Sanches Yassuda
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Cognitive Training ◽  
Functional Performance ◽  
Depression Scale ◽  
Cognitive Test ◽  
Age Related ◽  
The Impact

Abstract Aging is associated with cognitive decline, yet this does not prevent older adults from finding ways to compensate for age-related deficits. Earlier studies have shown that cognitively unimpaired older adults can benefit from training programs. The efficacy of cognitive interventions among older adults without dementia but with cognitive decline (mild cognitive impairment, MCI) has not yet been widely tested. Objectives: To evaluate the impact of 8-session cognitive training on the cognitive and functional performance of older adults with MCI. Methods: 16 older adults diagnosed with MCI received cognitive training (18 participated as controls). All participants were assessed pre and post intervention using the Short Cognitive Test (SKT), Direct Assessment of Functional Scale Revised (DAFS-R), Geriatric Depression Scale (GDS), and Clock Drawing Test (CDT). Results: A significant improvement was observed in the study group between pre and post-test in attention (SKT), time orientation, shopping skills and dealing with finances (DAFS-R) along with reduced depressive symptoms (GDS). Conclusion: These results indicate the importance of non-pharmacological interventions for older adults with MCI to help compensate for cognitive decline.

Cognitive Impairment and Seizures in Patients with Lacunar Strokes

2012 ◽  
Vol 8 (1) ◽  
pp. 27 ◽  
Author(s):  
Jacques De Reuck ◽  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Executive Functions ◽  
Cognitive Decline ◽  
Late Onset ◽  
Neuronal Circuits ◽  
Cerebrovascular Lesions ◽  
White Matter Changes ◽  
Cerebral Microangiopathy ◽  
Nun Study

Lacunar strokes are mainly related to cerebral microangiopathy and to the presence of leukoaraiosis. Cognitive impairment is frequently linked to the presence of lacunes and white matter changes. The cognitive impairment consists mainly of disturbances of executive functions sometimes leading to dementia. It is mainly due to interruption of the frontal-subcortical neuronal circuits. Seizures are also observed in patients with lacunes and white matter changes. Although lacunes cannot be considered as the cause of the seizures, there is a relationship between the occurrence of cognitive impairment and seizures. Repeated seizures promote further cognitive decline. However, the development of dementia in patients with late-onset epilepsy is most probably not directly due to the lacunes but rather due to Alzheimer's disease or to cortical cerebrovascular lesions. The development of lacunes should only be the aggravating factor for the cognitive decline as demonstrated in the Nun study.

scholarly journals The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 253 ◽  
Author(s):  
Giuseppe Caruso ◽  
Justyna Godos ◽  
Sabrina Castellano ◽  
Agnieszka Micek ◽  
Paolo Murabito ◽  
...  
Keyword(s):  
Systematic Review ◽  
Depressive Symptoms ◽  
Cognitive Decline ◽  
Clinical Studies ◽  
Therapeutic Potential ◽  
Meta Analysis ◽  
Preliminary Evidence ◽  
Elderly Subjects ◽  
Neuroprotective Effects ◽  
The Impact

Carnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at brain level and different preclinical studies have demonstrated its antioxidant, anti-inflammatory, and anti-aggregation activity with neuroprotective effects in animal models of Alzheimer’s disease (AD). A selective deficit of carnosine has also been linked to cognitive decline in AD. Different clinical studies have been conducted to evaluate the impact of carnosine supplementation against cognitive decline in elderly and AD subjects. We conducted a systematic review with meta-analysis, in accordance with the PRISMA guidelines coupled to the PICOS approach, to investigate the therapeutic potential of carnosine against cognitive decline and depressive symptoms in elderly subjects. We found five studies matching the selection criteria. Carnosine/anserine was administered for 12 weeks at a dose of 1 g/day and improved global cognitive function, whereas no effects were detected on depressive symptoms. These data suggest a preliminary evidence of clinical efficacy of carnosine against cognitive decline both in elderly subjects and mild cognitive impairment (MCI) patients, although larger and long-term clinical studies are needed in MCI patients (with or without depression) to confirm the therapeutic potential of carnosine.

scholarly journals Evaluation of the online-based self-help programme “Selfapy” in patients with unipolar depression: study protocol for a randomized, blinded parallel group dismantling study

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rico Krämer ◽  
Stephan Köhler
Keyword(s):  
Depressive Symptoms ◽  
Depression Scale ◽  
Drop Out ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Online Interventions ◽  
Phone Calls ◽  
Self Help ◽  
Low Threshold ◽  
The Impact

Abstract Background Patients with mild to moderate depressive symptoms can have limited access to regular treatment; to ensure appropriate care, low-threshold treatment is needed. Effective online interventions could increase the supply of low-threshold treatment. Further research is needed to evaluate the effectiveness of online interventions. This study aims to evaluate the online-based self-help programme “Selfapy” on a sample of depressive subjects and compares the impact of the programme’s unaccompanied version with its therapeutic accompanied version. Methods A sample of 400 subjects that have a mild to severe depressive episode (Becks Depression Inventory - II and Hamilton Depression Scale) will be used. Subjects are randomly assigned to immediate access to an unaccompanied course (no support from psychologist via weekly phone calls), immediate access to an accompanied course (support from a psychologist via weekly phone calls) or a waiting list control group (access to the intervention after 24 weeks). The intervention will last for a period of 12 weeks. Depressive symptoms as a primary parameter, as well as various secondary parameters, such as life satisfaction, therapeutic relationships, social activation, self-esteem, attitudes towards Internet interventions and drop-out rates, are recorded at four different points in time: at baseline (T1), 6 weeks after the start of the intervention (T2), 12 weeks after the start of the intervention (T3) and 3 months after completion of the treatment follow-up (T4). Conclusion This randomized and controlled, blinded study will make use of a “dismantled” approach to adequately compare the accompanied and unaccompanied versions of the intervention. Positive and meaningful results are expected that could influence the acceptance and implementation of online interventions. Trial registration German Clinical Trials Register DRKS00017191. Registered on 14 June 2019

scholarly journals The Impact of Work Hours on Depressive Symptoms among Koreans Aged 45 and Over

2021 ◽  
Vol 18 (3) ◽  
pp. 853
Author(s):  
Juyeong Kim ◽  
Eun-Cheol Park
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Social Services ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Work Hours ◽  
Middle Aged ◽  
Health Studies ◽  
Males And Females ◽  
The Impact

Background: Given the documented importance of employment for middle-aged and older adults’ mental health, studies of the association between their number of work hours and depressive symptoms are needed. Objectives: To examine the association between the number of work hours and depressive symptoms in Korean aged 45 and over. Methods: We used data from the first wave to fourth wave of the Korea Longitudinal Study of Aging. Using the first wave at baseline, data included 9845 individuals. Depressive symptoms were measured using the 10-item Center for Epidemiological Studies Depression scale. We performed a longitudinal analysis to estimate the prevalence of depressive symptoms by work hours. Results: Both unemployed males and females aged 45–65 years were associated with higher depressive symptoms (β = 0.59, p < 0.001; β = 0.32, p < 0.001). Females working ≥ 69 h were associated with higher depressive symptoms compared to those working 41–68 h (β = 0.25, p = 0.013). Among those both middle-aged and older adults, both males and females unemployed were associated with higher depressive symptoms. Those middle-aged female working ≥69 h were associated with higher depressive symptoms. Conclusions: An increase in depressive symptoms was associated with unemployed males and females working ≥69 h compared to those working 41–68 h. Although this association was found among middle-aged individuals, a decrease in depressive symptoms in both sexes was associated with working 1–40 h. Depressive symptoms should decrease by implementing employment policies and social services to encourage employers to support middle-aged and older adults in the workforce considering their sex and age differences.

The impact of cataract surgery on depressive symptoms for bilateral cataract patients in Ho Chi Minh City, Vietnam

2013 ◽  
Vol 26 (2) ◽  
pp. 307-313 ◽  
Author(s):  
Kien Gia To ◽  
Lynn B. Meuleners ◽  
Michelle L. Fraser ◽  
Dat Van Duong ◽  
Dung Van Do ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Depressive Symptoms ◽  
Cataract Surgery ◽  
Contrast Sensitivity ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Ho Chi Minh City ◽  
Bilateral Cataract ◽  
Vietnamese Population ◽  
The Impact

ABSTRACTBackground:Depression is common among older populations with cataract. However, the impact of cataract surgery on depression in both developed and developing countries remains unclear. The aim of this study is to determine the impact of cataract surgery on depressive symptoms and to examine the association between objective visual measures and change in depressive symptoms after surgery among a Vietnamese population in Ho Chi Minh City.Methods:A cohort of older patients with bilateral cataract were assessed the week before and one to three months after first eye surgery only or first- and second-eye cataract surgeries. Visual measures including visual acuity, contrast sensitivity, and stereopsis were obtained. Depressive symptoms were assessed using the 20-item Center for Epidemiological Studies-Depression Scale (CES-D). Descriptive analyses and a generalized estimating equations (GEE) analysis were undertaken to determine the impact of cataract surgery on depressive symptoms.Results:Four hundred and thirteen participants were recruited into the study before cataract surgery. Two hundred and forty-seven completed the follow-up assessment after surgery. There was a significant decrease (improvement) of one point in the depressive symptoms score (p = 0.04) after cataract surgery, after accounting for potential confounding factors. In addition, females reported a significantly greater decrease (improvement) of two points in depressive symptom scores (p = 0.01), compared to males. However, contrast sensitivity, visual acuity, and stereopsis were not significantly associated with change in depressive symptoms scores. First-eye cataract surgery or both-eye cataract surgery did not modify the change in depressive symptoms score.Conclusion:There was a small but significant improvement in depressive symptoms score after cataract surgery for an older population in Vietnam.

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