Head and neck cancer risk factors in India: protocol for systematic review and meta-analysis

IntroductionDemographic, behavioural and environmental factors have been associated with increased risk of head and neck cancer (HNC). We will review published reports and explore connections between risk factors and HNC incidence. This protocol aims to provide strategies for a systematic review and meta-analysis of HNC risk factor analysis in India. It also provides guidelines in order to visualise obtained HNC risk factor data in the form of a heat-map highlighting variations across gender, age and geographical location.Methods and analysisWe will identify well-established HNC risk factors and perform a comprehensive systematic review and meta-analysis to quantify each risk factor’s impact on HNC incidence. A systematic search will be performed to identify the studies and published reports of HNC risk factors in India. Meta-analysis will be conducted to estimate the proportional contribution of the most prevalent risk factor in HNC on a city-wide basis in Indian states and territories.Ethics and disseminationThe review protocol draws on publicly available anonymised data without directly involving human participants and therefore requires neither formal human ethical review nor approval by a human research ethics committee. We published an outline of the protocol in the International Prospective Register of Systematic Reviews (PROSPERO) in 2017. The results will provide an updated analysis of HNC risk factor prevalence in India, and we will discuss the applicability of rehabilitation care. We plan to disseminate the findings of this systematic review through publication in a peer-reviewed journal and presentation at relevant conference proceedings.PROSPERO registration numberCRD42017077758.

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Faculty Opinions recommendation of Volume-outcome associations in head and neck cancer treatment: a systematic review and meta-analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718141083.793502027 ◽

2014 ◽

Author(s):

Giulio Cantu ◽

Stefano Riccio ◽

Sarah Colombo

Keyword(s):

Systematic Review ◽

Head And Neck Cancer ◽

Cancer Treatment ◽

Head And Neck ◽

Neck Cancer ◽

Meta Analysis ◽

Volume Outcome

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Incidence of Oral Mucositis in Patients Undergoing Head and Neck Cancer Treatment: Systematic Review and Meta-Analysis

Medical Sciences Forum ◽

10.3390/msf2021005023 ◽

2021 ◽

Vol 5 (1) ◽

pp. 23

Author(s):

Raquel Pacheco ◽

Maria Alzira Cavacas ◽

Paulo Mascarenhas ◽

Pedro Oliveira ◽

Carlos Zagalo

Keyword(s):

Systematic Review ◽

Head And Neck Cancer ◽

Oral Health ◽

Cancer Treatment ◽

Head And Neck ◽

Neck Cancer ◽

Oral Mucositis ◽

Negative Impact ◽

Meta Analysis ◽

Incidence Rates

This systematic review and meta-analysis aimed to assess the literature about the incidence of oral mucositis and its degrees (mild, moderate, and severe), in patients undergoing head and neck cancer treatment (radiotherapy, chemotherapy, and surgery). Addressing this issue is important since oral mucositis has a negative impact on oral health and significantly deteriorates the quality of life. Therefore, a multidisciplinary team, including dentists, should be involved in the treatment. The overall oral mucositis incidence was 89.4%. The global incidence for mild, moderate, and severe degrees were 16.8%, 34.5%, and 26.4%, respectively. The high incidence rates reported in this review point out the need for greater care in terms of the oral health of these patients.

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