Short-term corticosteroid therapy in childhood asthma

1976 ◽  
Vol 14 (8) ◽  
pp. 31-32
Keyword(s):  
Sodium Cromoglycate ◽  
Corticosteroid Therapy ◽  
Childhood Asthma ◽  
Maintenance Treatment ◽  
High Dose ◽  
Severe Exacerbation ◽  
Short Term ◽  
At Home

Attacks of asthma in most children are relatively mild, but in a few they are severe and potentially fatal.1 The severity of attacks can be reduced by β-adrenoceptor stimulants, theophylline compounds and sodium cromoglycate, but when these are not effective it may be necessary to give a corticosteroid continuously. For those children who develop a severe exacerbation despite maintenance treatment, or those who get infrequent but often severe attacks that do not respond to bronchodilators, a short high-dose course of a corticosteroid can be given, and many practitioners choose to give this to their patients at home.2 However since no trials of such treatment have been performed the benefit remains unproven.

Severe exacerbation of hepatitis after short-term corticosteroid therapy in a patient with “latent” chronic hepatitis B

2000 ◽  
Vol 20 (5) ◽  
pp. 415-420 ◽  
Author(s):  
Goshi Shiota ◽  
Ken-ichi Harada ◽  
Kenji Oyama ◽  
Akihide Udagawa ◽  
Takahiro Nomi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Corticosteroid Therapy ◽  
Severe Exacerbation ◽  
Short Term

scholarly journals Bone turnover biomarkers in COPD patients randomized to either a regular or shortened course of corticosteroids: a substudy of the randomized controlled CORTICO-COP trial

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Pradeesh Sivapalan ◽  
Niklas R. Jørgensen ◽  
Alexander G. Mathioudakis ◽  
Josefin Eklöf ◽  
Therese Lapperre ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Dose Group ◽  
Low Dose ◽  
Corticosteroid Treatment ◽  
High Dose ◽  
Short Term ◽  
Copd Patients ◽  
Dose Corticosteroid

Abstract Background Long-term treatment with corticosteroids causes loss of bone density, but the effects of using short-term high-dose systemic-corticosteroid therapy to treat acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to determine whether high-dose corticosteroid therapy affected bone turnover markers (BTMs) to a greater extent compared to low-dose corticosteroid therapy. Methods The CORTICO-COP trial (NCT02857842) showed that an eosinophil-guided corticosteroid intervention led to approximately 60% lower accumulated corticosteroid dose for hospitalized patients with AECOPD (low-dose group) compared with 5-day standard corticosteroid treatment (high-dose group). We compared the levels of BTMs C-terminal telopeptide of type 1 collagen (CTX) and procollagen type 1 N-terminal propeptide (P1NP) in 318 participants during AECOPD and at 1- and 3-month follow-up visits. Results CTX decreased and P1NP increased significantly over time in both treatment groups. There were no significant differences between the groups at 1- or 3-months follow-up for P1NP. A significant drop in CTX was seen at 3 months (down Δ24% from the baseline, p = 0.017) for the high dose group. Conclusion Short-term, high-dose systemic corticosteroid treatment caused a rapid suppression of biomarkers of bone resorption. Corticosteroids did not suppress biomarkers of bone formation, regardless of patients receiving low or high doses of corticosteroids. This therapy was, therefore, harmless in terms of bone safety, in our prospective series of COPD patients. Trial registration ClinicalTrials.gov Identifier: NCT02857842. Submitted August 2nd, 2016.

scholarly journals Corticosteroid therapy for 2019-nCoV infected patients: a case series of 8 mechanically ventilated patients

2021 ◽  
Author(s):  
Mabrouk AL-Rasheedi ◽  
Yasir Alhazmi ◽  
Nouf Almaqwashi ◽  
Mateq Alreshidi ◽  
Abdulaziz Kardam ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Corticosteroid Therapy ◽  
Case Series ◽  
High Dose ◽  
Short Term ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Ventilated Patients

Objective To report a series of eight cases of severe acute respiratory syndrome due to 2019-nCoV infection (Covid-19- Bilateral infiltration) who were successfully treated with high-dose short-term corticosteroid therapy.

Introduction

2017 ◽  
Author(s):  
Frances Harris
Keyword(s):  
Cultural Influences ◽  
Short Term ◽  
Historical Figures ◽  
Platonic Love ◽  
Close Friendship ◽  
The Ideal ◽  
At Home

This introduces the Marlborough-Godolphin partnership as not just a political alliance, but a close friendship founded on ideals of platonic love and heroic virtue. It reviews the various discourses of friendship, noting the cultural influences (the essayists Montaigne, Sir William Temple, Saint-Évremond, as well as heroic drama and opera) which carried the ideal forward, but with the growing sense that it must prove itself in actual human transactions. It suggests that studying the Marlborough-Godolphin friendship as it proved itself in war abroad and party conflict at home is revealing of two historical figures whom historians have often found enigmatic, though in the end their commitment to it contributed to their short-term failure as well as their longer-term success. The distinction between friendship and royal favour is also touched on.

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