Adverse reactions to perhexiline (pexid)

1977 ◽  
Vol 15 (17) ◽  
pp. 68-68
Keyword(s):  
Peripheral Neuropathy ◽  
Liver Function ◽  
Adverse Reactions ◽  
Liver Function Tests ◽  
Function Tests ◽  
Β Blockers ◽  
Altered Liver

Last December we concluded that ‘perhexiline (Pexid - Merrell) is probably worth trying in patients with severe angina when nitrates and β-blockers control symptoms poorly. Minor unwanted effects and altered liver function tests are very common. Overt hepatotoxicity and peripheral neuropathy seem infrequent but the risks must be borne in mind’.1

scholarly journals Pancytopenia and Peripheral Neuropathy in a Woman with Altered Liver Function Tests

2019 ◽  
Vol 65 (8) ◽  
pp. 956-960 ◽  
Author(s):  
Eduardo Martínez-Morillo ◽  
María García-García ◽  
Clara Barneo-Caragol ◽  
Alejandra Fernández Fernández ◽  
Francisco V Álvarez
Keyword(s):  
Peripheral Neuropathy ◽  
Liver Function ◽  
Liver Function Tests ◽  
Function Tests ◽  
Altered Liver

scholarly journals Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy

2020 ◽  
Vol 15 (8) ◽  
pp. 1399-1407 ◽  
Author(s):  
Marco Vincenzo Lenti ◽  
◽  
Federica Borrelli de Andreis ◽  
Ivan Pellegrino ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Intensive Care ◽  
Liver Function ◽  
Laboratory Data ◽  
Liver Function Tests ◽  
Gamma Glutamyl Transpeptidase ◽  
Function Tests ◽  
Altered Liver ◽  
The Impact ◽  
Internal Medicine Unit

Abstract Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO2/FiO2 < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07–5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.

Prognostic Value of Altered Liver Function Tests in Critically Ill Patients

2015 ◽  
Vol 5 ◽  
pp. S74
Author(s):  
Krishna Tejaswy ◽  
Harshavardhan Rao ◽  
Rajesh Gopalakrishna ◽  
Ismail Siyad ◽  
Shine Sadasivan ◽  
...  
Keyword(s):  
Liver Function ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Prognostic Value ◽  
Liver Function Tests ◽  
Function Tests ◽  
Altered Liver

scholarly journals SARS-CoV-2 Infection Induces a Dual Response in Liver Function Tests: Association with Mortality during Hospitalization

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 328 ◽  
Author(s):  
Vanesa Bernal-Monterde ◽  
Diego Casas-Deza ◽  
Laura Letona-Giménez ◽  
Natalia de la Llama-Celis ◽  
Pilar Calmarza ◽  
...  
Keyword(s):  
Liver Function ◽  
Mixed Models ◽  
Liver Function Tests ◽  
Respiratory Complications ◽  
Liver Test ◽  
Function Tests ◽  
Dual Response ◽  
Altered Liver ◽  
Test Result

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with abnormal liver function tests. We hypothesized that early altered liver biochemistries at admission might have different clinical relevance than subsequent changes during hospitalization. A single-center retrospective study was conducted on 540 consecutive hospitalized patients, PCR-diagnosed with SARS-CoV-2. Liver test abnormalities were defined as the elevation of either gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT), or aspartate aminotransferase (AST), above the upper limit of normality set by our laboratory. Linear mixed models (LMM) evaluated longitudinal associations, incorporating all available follow-up laboratory chemistries. By the end of the follow-up period, 502 patients (94.5%) were discharged (109 (20.5%) died). A total of 319 (64.3%) had at least one abnormal liver test result at admission. More prevalent were elevated AST (40.9%) and GGT (47.3%). Abnormalities were not associated with survival but with respiratory complications at admission. Conversely, LMM models adjusted for age and sex showed that longitudinal increases during hospitalization in ferritin, GGT, and alkaline phosphatase (ALP), as well as a decreased albumin levels, were associated with reduced survival. This dual pattern of liver damage might reconcile previous conflicting reports. GGT and ALP trajectories could be useful to determine who might need more surveillance and intensive care.

Relevance of liver function tests in pulmonary hypertension

2014 ◽  
Vol 52 (08) ◽  
Author(s):  
KC Grotemeyer ◽  
H Wilkens ◽  
F Lammert ◽  
R Bals ◽  
R Kaiser
Keyword(s):  
Pulmonary Hypertension ◽  
Liver Function ◽  
Liver Function Tests ◽  
Function Tests
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