Choosing the drug to treat hypertension

1971 ◽  
Vol 9 (20) ◽  
pp. 77-79
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Drug Combination ◽  
Effective Drug ◽  
Hypotensive Drugs ◽  
The Many

In most patients with sustained elevation of blood pressure the diagnosis is that of essential hypertension. With the many hypotensive drugs now available, it may be difficult to decide which drug, or drug combination, should be given to a particular patient. The decision is particularly important because treatment is usually life-long and the aim is to find an effective drug regime which suits the patient and produces minimal unwanted effects.

COMPARISON OF EFFICACY OF TELMISARTAN AND AMLODIPINE IN PATIENTS OF HYPERTENSION PRESCRIBED AS FREE DRUG AND AS FIXED DOSE COMBINATION.

2021 ◽  
pp. 53-55
Author(s):  
Ritu shitak ◽  
Anurag thakur ◽  
Malvika shitak ◽  
Sanjay sharma
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Vascular Disease ◽  
Diastolic Blood Pressure ◽  
Drug Combination ◽  
Free Drug ◽  
Drug Combinations ◽  
Fixed Dose ◽  
Newly Diagnosed ◽  
Dose Combination

INTRODUCTION: HTN remains one of the major preventable risk factors for coronary events, cerebral-vascular disease, heart failure, peripheral vascular disease and progression of kidney disease. Most patients with HTN will require more than one drug to achieve BP target. In addition, around 24% to 32% of patients will require a combination of more than two drugs to achieve BP targets. Combination therapy for HTN may be delivered either as free or xed drug combinations. In a free drug combination, each BP-lowering drug is administered in a separate pill, while in a xed drug combination two or more agents are combined in a single pill (SPC). SPCs may offer several advantages over free drug combinations, such as better compliance and simplicity of treatment. MATERIAL AND METHOD: Study was conducted for a span of one year. Every patient coming to medicine OPD for the treatment of hypertension, who has already been prescribed 40mg Telmisartan or 5mg amlodipine individually were included also the newly diagnosed patients for essential hypertension were included. INCLUSION CRITERIA: (a) 18- 60 years, Adults of either sex (b) Newly diagnosed patients of essential hypertension (c) Already diagnosed old patients on treatment for essential hypertension with 40mg Telmisartan or 5mg Amlodipine. EXCLUSION CRITERIA:(a) Patients with chronic diseases e.g. Diabetes mellitus, CKD & CAD(b) Pregnant & lactating females. RESULTS:Total 267 patients were enrolled in the study. Age and sex wise distribution was given in table no. 1.1. 138 patients were started on telmisartan and amlodipine free drug and 129 patients were started on telmisartan and amlodipine xed drug. Majority of patients were less than 60 years and 121(45.3%) patients were male and 146(54.7%) patients were female. 138 Patients were started on telmisartan and amlodipine free drug group. 28.3% patients were on amlodipine and 25.4% patients were on telmisartan where as 46.4% patients were not taking any antihypertensive treatment and mean systolic and diastolic blood pressure in this group was 168.3±14.2: 95.4±7.2. 129 patients were started on telmisartan and amlodipine xed dose combination. 31% patients were on amlodipine and 24.8% patients were on telmisartan where as 44.2% were not taking any drugs and mean systolic and diastolic blood pressure in this group was 167.8±15.6: 95.7±7.1. CONCLUSION: Telmisartan/amlodipine combination when administered separately at different times of the day showed good to excellent responsea

Management of hypertension in pregnancy

1967 ◽  
Vol 5 (13) ◽  
pp. 49-51
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Renal Biopsy ◽  
Lower Threshold ◽  
General Physician ◽  
Maternal Deaths ◽  
Hypertension In Pregnancy ◽  
Hypotensive Drugs ◽  
Treatment Of Hypertension ◽  
In Pregnancy

Perinatal and maternal deaths are increased by hypertension in pregnancy.1 2 This comprises (1) essential hypertension, (2) other varieties of hypertension, (3) pre-eclamptic toxaemia of pregnancy, and (4) toxaemia complicating (1) and (2). The treatment of hypertension in pregnancy varies considerably, particularly in the use of hypotensive drugs. This variation arises partly because the obstetrician has a lower threshold for what constitutes ‘hypertension’ in his patients than has the general physician, partly because pre-eclamptic toxaemia is difficult to distinguish from essential and other hypertension in pregnancy and partly from our ignorance of the aetiology and fundamental lesion in the former. Specific microscopic changes have been found on renal biopsy,3 but these lesions may be present in only a minority of those diagnosed clinically as toxaemia.4 At present therefore treatment can only be directed at lowering the blood pressure.

scholarly journals From Brain to Behavior: Hypertension's Modulation of Cognition and Affect

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
J. Richard Jennings ◽  
Alicia F. Heim
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Psychological Factors ◽  
Imaging Findings ◽  
Contributory Factors ◽  
The Many ◽  
The Brain ◽  
Initial Blood ◽  
Initial Blood Pressure ◽  
Human Neuroimaging

Accumulating evidence from animal models and human studies of essential hypertension suggest that brain regulation of the vasculature is impacted by the disease. Human neuroimaging findings suggest that the brain may be an early target of the disease. This observation reinforces earlier research suggesting that psychological factors may be one of the many contributory factors to the initiation of the disease. Alternatively or in addition, initial blood pressure increases may impact cognitive and/or affective function. Evidence for an impact of blood pressure on the perception and experience of affect is reviewed vis-a-vis brain imaging findings suggesting that such involvement in hypertensive individuals is likely.

DAILY BLOOD PRESSURE PATTERN DISORDERS IN PATIENTS WITH STAGE II ESSENTIAL HYPERTENSION AND FREQUENT PREMATURE BEATS

2020 ◽  
Vol 16 (71) ◽  
pp. 072
Author(s):  
N. V. Kuzminova ◽  
A. V. Ivankova ◽  
V. P. Ivanov ◽  
S. E. Lozinsky ◽  
I. I. Knyazkova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Stage Ii ◽  
Pressure Pattern ◽  
Premature Beats
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