DAILY BLOOD PRESSURE PATTERN DISORDERS IN PATIENTS WITH STAGE II ESSENTIAL HYPERTENSION AND FREQUENT PREMATURE BEATS

2020 ◽  
Vol 16 (71) ◽  
pp. 072
Author(s):  
N. V. Kuzminova ◽  
A. V. Ivankova ◽  
V. P. Ivanov ◽  
S. E. Lozinsky ◽  
I. I. Knyazkova ◽  
...  
1976 ◽  
Vol 51 (s3) ◽  
pp. 687s-689s ◽  
Author(s):  
C. W. G. Redman ◽  
L. J. Beilin ◽  
J. Bonnar

1. Reversal of the normal diurnal blood pressure pattern has been demonstrated in women with severe hypertension and renal impairment in pregnancy (pre-eclampsia). 2. Maximum arterial pressure occurred at night in these women. The phenomenon was not due to hypotensive drug therapy or posture. Patients with uncomplicated essential hypertension in pregnancy retained a normal diurnal blood pressure pattern. 3. Nocturnal hypertension in pre-eclampsia is of theoretical interest and practical importance.


Author(s):  
OA Radaeva ◽  
AS Simbirtsev ◽  
AV Khovryakov

Today, increasing attention is being paid to the role of circadian rhythms in pathology. There are time-of-day-dependent immune markers that provide valuable information about disease progression. The aim of this study was to measure evening and morning concentrations of a few cytokines (interleukins, adhesion molecules, tumor necrosis/growth factors, etc.) in the peripheral blood of patients with stage II essential hypertension and to investigate how they correlate with a nocturnal blood pressure decline. Blood samples were collected from 90 patients with stage II EH at 7:00 a.m. and 8:00 p.m. Cytokine concentrations were measured using immunoassays. Based on 24-h blood pressure monitoring, the patients were distributed into 3 groups: dippers, non-dippers and night-peakers. The morning to evening ratios of cytokine concentrations in patients with EH differed from those in healthy controls due to an increase in the evening concentrations of somnogenic cytokines (IL1β, IL1α) and LIF, sLIFr, and M-CSF whose daily fluctuations patterns remain understudied. On the whole, the fluctuation patterns of the measured cytokines in patients with stage II EH who had had the condition for 10 to 14 years and were receiving no antihypertensive treatment at the time of our study differed from those displayed by healthy controls. A twenty percent rise in the evening concentrations of IL1α, LIF, sLIFr, M-CSF, and erythropoietin contributes significantly to pathological blood pressure rhythms (as demonstrated by the groups of non-dippers and night-peakers) in patients with stage II EH receiving no antihypertensive therapy. Understanding the pathophysiological role of cytokine levels and their fluctuations over a 24-h cycle could inspire new methods for EH prevention and reduce end-organ damage.


2017 ◽  
Vol 21 (4) ◽  
pp. 38
Author(s):  
A. V. Sandugei ◽  
M. V. Ilyin ◽  
O. A. Khrustalev ◽  
N. S. Baranova ◽  
N. V. Emanuilova ◽  
...  

<p><strong>Aim.</strong> The purpose of the study was to investigate the character of changes in daily blood pressure profiles and to evaluate the influence of Borrelia burgdorferi infection on the course of essential hypertension in patients with acute stage of Lyme disease.<br /><strong>Methods.</strong> 37 patients with an acute stage of Lyme disease were examined and broken down in two groups. The first group included 18 patients without essential hypertension. 19 patients with stage II of essential hypertension were included into group II. The group of comparison consisted of 32 patients with stage II of essential hypertension without Lyme disease. 26 healthy volunteers of the control group were comparable in gender and age.<br /><strong>Results.</strong> A significant difference of the average diastolic blood pressure index during night time in patients with acute stage of Lyme disease and essential hypertension 90.0 (68.5–100.0) mm Hg versus the control group 77.0 (65.0–86.0) mm Hg at p = 0.03 was observed. When determining a type of daily blood pressure profile, some features of a blood pressure circadian rhythm were found in all groups of patients. There were ‘Dipper’ (77.7%) and ‘Non-Dipper’ (22.3%) profiles in the group of patients with acute stage of Lyme disease without essential hypertension. No ‘Over-Dipper’ and ‘Night-Peaker’ profiles were recorded in this group. 'Dipper’ (20.0%), ‘Non-Dipper’ (73.4%) and ‘Night-Peaker’ (6.6%) blood pressure profiles were typical for patients with acute stage of Lyme disease and essential hypertension. <br /><strong>Conclusion.</strong> A 22.3% decrease in the number of patients with a ‘Dipper’ blood pressure daily profile and an equal increase in the number of ‘non-dipper’ patients are characteristic of an acute stage of Lyme disease. The number of ‘Non-Dipper’ patients with essential hypertension and acute stage of Lyme disease increases up to 73.4%. Thus, acute Lyme disease and essential hypertension tend to burden the each other’s course.</p><p>Received 10 May 2017. Revised 7 September 2017. Accepted 25 September 2017.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest:</strong> Authors declare no conflict of interest.</p><p><strong>Author contributions</strong><br />Conception and study design: A.V. Sandugei, M.V. Ilyin, O.A. Khrustalev, N.S. Baranova. <br />Data collection and analysis: A.V. Sandugei, O.A. Khrustalev, N.V. Emanuilova. <br />Statistical data analysis: A.V. Sandugei, N.V. Emanuilova, O.Yu. Churakov.<br />Drafting the article: A.V. Sandugei, N.V. Emanuilova, V.V. Neusypin. <br />Critical revision of the article: A.V. Sandugei, N.V. Emanuilova, V.V. Neusypin.<br />Final approval of the version to be published: A.V. Sandugei, M.V. Ilyin, O.A. Khrustalev, N.S. Baranova, N.V. Emanuilova, O.Yu. Churakov, V.V. Neusypin</p>


2007 ◽  
Vol 14 (3) ◽  
pp. 145-196
Author(s):  
C Paglieri ◽  
D Bisbocci ◽  
P Cerrato ◽  
F Rabbia ◽  
P Perozzo ◽  
...  

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