Dietary sugars versus glucose tablets for first-aid treatment of symptomatic hypoglycaemia in awake patients with diabetes: a systematic review and meta-analysis

UNSTRUCTURED Aims: This systematic review and meta-analysis aimed to evaluate the effects of wearable technologies on HbA1c, blood pressure, body mass index (BMI), and fastening blood glucose (FBG) in patients with diabetes. Methods: We searched PubMed, Scopus, Embase, the Cochrane database, and the Chinese CNKI database from last 15 years until August 2021. The quality of the 16 included studies was assessed using the PEDro scale, and random effect models were used to estimate outcomes, with I2 used for heterogeneity testing. Results: A significant reduction in HbA1c (-0.475% [95% CI -0.692 to -0.257, P<0.001]) was found following telemonitoring. However, the results of the meta-analysis did not show significant changes in blood pressure, BMI, and glucose, in the intervention group (P>0.05), although the effect size for systolic blood pressure (0.389) and diastolic blood pressure may indicate a significant effect. Subgroup analysis revealed statistically significant effects of wearable technologies on HbA1c when supported by dietetic interventions (P<0.001), medication monitoring (P<0.001), and relapse prevention (P<0.001). Online messages and telephone interventions significantly affected HbA1c levels (P<0.001). Trials with additional online face-to-face interventions showed greater reductions in HbA1c levels. Remote interventions including dietetic advice (P<0.001), medication (P<0.001), and relapse prevention (P<0.001) during telemonitoring showed a significant effect on HbA1c, particularly in patients attending ten or more intervention sessions (P<0.001). Conclusion: Wearable technologies can improve diabetes management by simplifying self-monitoring, allowing patients to upload their live measurement results frequently and thereby improving the quality of telemedicine. Wearable technologies also facilitate remote medication management, dietetic interventions, and relapse prevention.

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The Clinical Effect of Metformin on the Survival of Lung Cancer Patients with Diabetes: A Comprehensive Systematic Review and Meta-analysis of Retrospective Studies

Journal of Cancer ◽

10.7150/jca.19750 ◽

2017 ◽

Vol 8 (13) ◽

pp. 2532-2541 ◽

Cited By ~ 14

Author(s):

Xun Cao ◽

Zhe-Sheng Wen ◽

Xu-Dong Wang ◽

Yong Li ◽

Kui-Yuan Liu ◽

...

Keyword(s):

Lung Cancer ◽

Systematic Review ◽

Cancer Patients ◽

Clinical Effect ◽

Retrospective Studies ◽

Meta Analysis ◽

Lung Cancer Patients ◽

Patients With Diabetes

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Effectiveness of Continuous Glucose Monitoring in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis.

10.1210/endo-meetings.2010.part2.p12.p2-560 ◽

2010 ◽

pp. P2-560-P2-560

Author(s):

HC Yeh ◽

AS Eckman ◽

TT Brown ◽

JC Brick ◽

CD Saudek

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Continuous Glucose Monitoring ◽

Meta Analysis ◽

Glucose Monitoring ◽

Patients With Diabetes

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Effects of gluten free diet in patients with diabetes mellitus type1: systematic review and meta-analysis

10.37766/inplasy2020.6.0010 ◽

2020 ◽

Author(s):

Tamy Colonetti ◽

Micheli Mariot ◽

Laura Colonetti ◽

Marina Costa

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Meta Analysis ◽

Gluten Free Diet ◽

Gluten Free ◽

Patients With Diabetes

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Association of myocardial fibrosis detected by late gadolinium-enhanced MRI with clinical outcomes in patients with diabetes: a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2021-055374 ◽

2022 ◽

Vol 12 (1) ◽

pp. e055374

Author(s):

Zhi Yang ◽

Rong Xu ◽

Jia-rong Wang ◽

Hua-yan Xu ◽

Hang Fu ◽

...

Keyword(s):

Systematic Review ◽

Risk Stratification ◽

Myocardial Fibrosis ◽

Meta Analysis ◽

Imaging Biomarker ◽

Cardiac Events ◽

Prognostic Information ◽

Increased Risk ◽

Patients With Diabetes

ObjectiveThis meta-analysis assessed the associations of myocardial fibrosis detected by late gadolinium-enhanced (LGE)-MRI with the risk of major adverse cardiac and cerebrovascular events (MACCEs) and major adverse cardiac events (MACEs) in patients with diabetes.DesignSystematic review and meta-analysis reported in accordance with the guidelines of the Meta-analysis of Observational Studies in Epidemiology statement.Data sourcesWe searched the Medline, Embase and Cochrane by Ovid databases for studies published up to 27 August 2021.Eligibility criteriaProspective or respective cohort studies were included if they reported the HR and 95% CIs for MACCEs/MACEs in patients with either type 1 or 2 diabetes and LGE-MRI-detected myocardial fibrosis compared with patients without LGE-MRI-detected myocardial fibrosis and if the articles were published in the English language.Data extraction and synthesisTwo review authors independently extracted data and assessed the quality of the included studies. Pooled HRs and 95% CIs were analysed using a random effects model. Heterogeneity was assessed using forest plots and I2 statistics.ResultsEight studies with 1121 patients with type 1 or type 2 diabetes were included in this meta-analysis, and the follow-up ranged from 17 to 70 months. The presence of myocardial fibrosis detected by LGE-MRI was associated with an increased risk for MACCEs (HR: 2.58; 95% CI 1.42 to 4.71; p=0.002) and MACEs (HR: 5.28; 95% CI 3.20 to 8.70; p<0.001) in patients with diabetes. Subgroup analysis revealed that ischaemic fibrosis detected by LGE was associated with MACCEs (HR 3.80, 95% CI 2.38 to 6.07; p<0.001) in patients with diabetes.ConclusionsThis study demonstrated that ischaemic myocardial fibrosis detected by LGE-MRI was associated with an increased risk of MACCEs/MACEs in patients with diabetes and may be an imaging biomarker for risk stratification. Whether LGE-MRI provides incremental prognostic information with respect to MACCEs/MACEs over risk stratification by conventional cardiovascular risk factors requires further study.

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