scholarly journals Drinking habits as cofactors of risk for alcohol induced liver damage

Gut ◽  
1997 ◽  
Vol 41 (6) ◽  
pp. 845-850 ◽  
Author(s):  
S Bellentani ◽  
G Saccoccio ◽  
G Costa ◽  
C Tiribelli ◽  
F Manenti ◽  
...  
Keyword(s):  
At Risk ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Liver Damage ◽  
Alcohol Intake ◽  
Alcoholic Beverage ◽  
Chronic Liver ◽  
Alcoholic Beverages ◽  
Risk Threshold ◽  
Open Population

Background—The Dionysos Study is a cohort study of the prevalence of chronic liver disease in the general population of two northern Italian communities. It included 6917 subjects, aged 12–65 (69% of the total population).Aims—The aim of this part of the study was to examine the relationship of daily alcohol intake, type of alcoholic beverage consumed, and drinking patterns to the presence of alcohol induced liver damage in an open population.Patients and methods—6534 subjects, free of virus related chronic liver disease and participating in the first cross-sectional part of the study, were fully examined. Each subject underwent: (a) medical history and physical examination, (b) evaluation of alcohol intake using an illustrated dietary questionnaire, and (c) routine blood tests. More invasive diagnostic procedures were performed when indicated.Results—Multivariate analysis showed that the risk threshold for developing either cirrhosis or non-cirrhotic liver damage (NCLD) was ingestion of more than 30 g alcohol per day in both sexes. Using this definition, 1349 individuals (21% of the population studied) were at risk. Of these, only 74 (5.5% of the individuals at risk) showed signs of liver damage. The prevalence of “pure” alcoholic cirrhosis was 0.43% (30 of 6917), representing 2.2% of the individuals at risk, with a ratio of men to women of 9:1, while 44 (3.3% of the individuals at risk) showed persistent signs of NCLD. After 50 years of age, the cumulative risk of developing both NCLD and cirrhosis was significantly higher (p<0.0001) for those individuals who regularly drank alcohol both with and without food than for those who drank only at mealtimes.Conclusions—Our data show that in an open population the risk threshold for developing cirrhosis and NCLD is 30 g ethanol/day, and this risk increases with increasing daily intake. Drinking alcohol outside mealtimes and drinking multiple different alcoholic beverages both increase the risk of developing alcohol induced liver damage.

Measurement of food and alcohol intake in relation to chronic liver disease

2008 ◽  
Vol 18 (3) ◽  
pp. 285-301 ◽  
Author(s):  
Wendy L Wrieden ◽  
Annie S Anderson
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Alcohol Intake ◽  
Chronic Liver ◽  
Alcoholic Beverages ◽  
Validity And Reliability ◽  
Time Period ◽  
Food And Drink ◽  
Short Time ◽  
The Impact

It is well established that the consumption of alcohol is implicated in both the cause and progression of chronic liver disease. The quantity of drink that is consumed, the pattern of drinking and type of alcoholic beverages consumed are all possible factors in disease aetiology. The impact of specific dietary components on the cause and progression of chronic liver disease is unclear although it is known that obesity, and hence the over-consumption of energy, is a predictor of fatty liver. Work to elucidate the role of both diet and alcohol in the aetiology of liver disease is hindered by the methods currently available to measure dietary (including alcohol) intake. The validity and reliability of retrospective methods of assessing diet are limited by their reliance on memory and, for the 24 h recall, the short-time period of intake assessed and its inability to assess variability across the week. Prospective methods which measure food and drink intake at the time of consumption, and include weighed or estimated food diaries, are useful for prospective cohort studies but are expensive and have a high respondent burden. For estimation of alcohol intake retrospectively, the Cognitive Lifetime Drinking questionnaire, which prompts responses using a lifetime calendar, is a useful tool but still depends on memory. More work is required to develop valid, reliable and easily administered tools for measurement of both diet and alcohol.

scholarly journals Outcomes of excessive alcohol drinkers without baseline evidence of chronic liver disease after 15 years follow-up: Heavy burden of cancer and liver disease mortality

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252218
Author(s):  
Sónia Bernardo ◽  
Ricardo Crespo ◽  
Sofia Saraiva ◽  
Rui Barata ◽  
Sara Gonçalves ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Chronic Liver Disease ◽  
Alcohol Intake ◽  
Chronic Liver ◽  
Portuguese Population ◽  
Heavy Drinkers ◽  
Heavy Burden

Background Most long-term heavy drinkers do not have clinically evident chronic liver disease (CLD). However, at any time-point, their risk of developing CLD remains unknown. We aimed to evaluate the long-term outcomes of a group of heavy drinkers, without evidence of CLD at baseline. Methods A cohort of 123 long-term heavy drinkers without CLD were prospectively recruited in 2002 and retrospectively followed until 2018. Results At baseline (2002), median alcohol consumption was 271±203g/day during 21.5±20 years, 65% being abstinent during the previous 1.75±5 months. Patients were followed for 14±3 years. During follow-up, 53% reported any alcohol intake. Alcohol consumption during follow-up associated weakly with either 1- or 6-months previous abstinence at baseline. Until 2018, progression to CLD occurred in 6%, associating with years of alcohol intake during follow-up (OR 1.15 [1.01–1.31]) and baseline alkaline-phosphatase (OR 1.05 [1.01–1.10]). During follow-up, being abstinent for at least 1 year positively associated with CLD-free survival. 27% died (55% of cancer–mostly oropharyngeal cancer, 27% of cardiovascular disease, and 9% of liver disease), with a mean age of 71 years [69–74] (10 years less than the expected in the Portuguese population). Achieving abstinence for at least 1 year positively associated with overall survival, while smoking, and hepatic steatosis at baseline associated negatively. Conclusion Long-term heavy drinkers seemed to have a decreased life expectancy compared with the overall Portuguese population. Cancer was the main cause of death. Our results suggest that progression to CLD depends mostly on continued alcohol intake. Alcohol abstinence, even if temporary, seems to decrease the risks of CLD and mortality.

scholarly journals External validation of an algorithm combining multi‐analyte blood tests (FibroTest‐LCR1‐LCR2) to identify subjects at risk of hepatocellular carcinoma in patients with chronic liver disease

GastroHep ◽  
2019 ◽  
Vol 1 (3) ◽  
pp. 146-153
Author(s):  
Valentina Peta ◽  
Marianne Ziol ◽  
Françoise Imbert‐Bismut ◽  
Angela Sutton ◽  
Denis Monneret ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
External Validation ◽  
Chronic Liver ◽  
Blood Tests

Upper normal threshold of serum alanine aminotransferase in identifying individuals at risk for chronic liver disease

2012 ◽  
Vol 32 (6) ◽  
pp. 937-944 ◽  
Author(s):  
Ha Na Park ◽  
Dong Hyun Sinn ◽  
Geum-Youn Gwak ◽  
Jee Eun Kim ◽  
Sang Youl Rhee ◽  
...  
Keyword(s):  
At Risk ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Alanine Aminotransferase ◽  
Chronic Liver ◽  
Normal Threshold ◽  
Serum Alanine Aminotransferase

scholarly journals CLINICOPATHOLOGICAL CORRELATION IN CHRONIC LIVER DISEASE AND HEPATOCELLULAR CRCINOMA

2020 ◽  
pp. 1-2
Author(s):  
A. Vijayalakshmi ◽  
s. Malliga
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Alcohol Intake ◽  
Normal Liver ◽  
Chronic Liver ◽  
Clinicopathological Correlation ◽  
Chronic Alcohol ◽  
Hepatocellular Injury ◽  
Medical College

Cirrhosis can occur as result of various chronic hepatic disease and the incidence of hepatocellular carcinoma arising from cirrhosis is also variable depending on the etiology resulting cirrhosis. Viral hepatitis and alcohol consumption are the most world-wide among the most common causes of HCC.we planned this study to nd out the the clinicopathological correlation in chronic liver disease and HCC. This study was done after obtaining the approval from Institutional Human Ethical Committee (IHEC) of Govt. Stanley Medical College, Chennai. 65 liver specimens were taken for this study. Hematoxylin and eosin staining of sections were done. Histopathological examinations of these sections were done. The cases showed an age range from 15 to 73 years. The cases with normal liver histology in the age ranges 15 to 35 years, hepatitis ranges 19 to 51, cirrhosis ranges 15 t0 73 years and the HCC ranges 34-73 years. 45 cases were males and 16 were females.Amongst 8 cases of hepatitis, 4(50%) were males and 4(50%) were females. Amongst 17 cases of cirrhosis, 12(71%) were males and 5(29%) were females. Amongst 30 cases of HCC, 25(83%) were males and 5(17%) were females. chronic alcohol intake history was found in 50% of hepatitis patients, 63% of cirrhosis patients and 83% of HCC patients. In this study the most common risk factor for HCC is chronic alcohol intake followed by viral hepatitis.the signicance of the development of hepatocellular carcinoma in the background of chronic hepatocellular injury has been highlighted.

scholarly journals Use of anti-platelet agents in the prevention of hepatic fibrosis in patients at risk for chronic liver disease: a systematic review and meta-analysis

2018 ◽  
Vol 13 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Umair Iqbal ◽  
Brittany B. Dennis ◽  
Andrew A. Li ◽  
George Cholankeril ◽  
Donghee Kim ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Hepatic Fibrosis ◽  
Meta Analysis ◽  
Chronic Liver ◽  
Patients At Risk
Sign in / Sign up

Export Citation Format

Share Document