scholarly journals OWE-18 Non-responsive and refractory coeliac disease: the largest UK experience from the NHS england national centre

2019 ◽  
Author(s):  
Elisabeth MR Baggus ◽  
Anupam Rej ◽  
Annalisa Schiepatti ◽  
Lauren J Marks ◽  
Nick Trott ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
National Centre ◽  
Refractory Coeliac Disease

scholarly journals Non-Responsive Coeliac Disease: A Comprehensive Review from the NHS England National Centre for Refractory Coeliac Disease

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 216 ◽  
Author(s):  
Hugo A. Penny ◽  
Elisabeth M. R. Baggus ◽  
Anupam Rej ◽  
John A. Snowden ◽  
David S. Sanders
Keyword(s):  
Coeliac Disease ◽  
Systematic Approach ◽  
Intestinal Inflammation ◽  
Gluten Free ◽  
Comprehensive Review ◽  
National Centre ◽  
Alternative Condition ◽  
Small Intestinal ◽  
Symptoms And Signs ◽  
Refractory Coeliac Disease

Coeliac disease is a common small intestinal enteropathy which manifests following ingestion of gluten in genetically susceptible individuals. Since gluten was identified as the driving factor in coeliac disease, the gluten-free diet (GFD) has remained the mainstay of treatment. While most individuals will display improvement in symptoms and signs of coeliac disease following institution of the GFD, up to 30% will continue to experience symptoms and/or have persisting intestinal inflammation. These individuals can be classified as having non-responsive coeliac disease (NRCD), which may be associated with dietary indiscretion, slow healing, refractory coeliac disease, and/or an alternative condition. The purpose of this review is to provide an overview of the causes of NRCD in adults, highlight a systematic approach to investigate these patients, and appraise the latest management aspects of this subset of coeliac disease.

Refractory coeliac disease type I and II; Pilot-treatment with azathioprine and predinison

2001 ◽  
Vol 120 (5) ◽  
pp. A131-A131 ◽  
Author(s):  
C MULDER ◽  
P WAHAB ◽  
A TAN ◽  
J MEIJER
Keyword(s):  
Coeliac Disease ◽  
Disease Type ◽  
Type I ◽  
Refractory Coeliac Disease

scholarly journals Faecal Scent as a Novel Non-Invasive Biomarker to Discriminate between Coeliac Disease and Refractory Coeliac Disease: A Proof of Principle Study

Biosensors ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 69 ◽  
Author(s):  
Maxine D. Rouvroye ◽  
Alfian Wicaksono ◽  
Sofie Bosch ◽  
Edo Savelkoul ◽  
James A. Covington ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Ion Mobility ◽  
Clinical Symptoms ◽  
Area Under The Curve ◽  
Gluten Free ◽  
Future Studies ◽  
Non Invasive ◽  
Significant Difference ◽  
Volatile Organic ◽  
Refractory Coeliac Disease

Currently, the gold standard for diagnosis of coeliac disease (CD) is based on serology and gastroduodenoscopy with histology of duodenal mucosal biopsies. The aim of this study was to evaluate the potential of faecal volatile organic compounds (VOCs) analysis as a novel, non-invasive tool to discriminate between CD in remission in patients on a gluten-free diet (GFD), refractory coeliac disease (RCD) and controls without CD. Patients with an established diagnosis of CD on a GFD, RCD and healthy controls (HC) were instructed to collect a faecal sample. All subjects completed questionnaires on clinical symptoms, lifestyle and dietary information. Faecal VOCs were measured using gas chromatography-ion mobility spectrometry. A total of 13 CD, 7 RCD and 10 HC were included. A significant difference in VOC profiles between CD and RCD patients (area under the curve (AUC) ± 95% CI: 0.91 (0.79–1) p = 0.000) and between CD and HC (AUC ± 95% CI: 0.71 (0.51–0.91) p = 0.0254) was observed. We found no significant differences between faecal VOC patterns of HC and RCD. Based on faecal VOCs, CD could be discriminated from RCD and HC. This implies that faecal VOC analysis may hold potential as a novel non-invasive biomarker for RCD. Future studies should encompass a larger cohort to further investigate and validate this prior to application in clinical practice.

scholarly journals Refractory Coeliac Disease, Small-Bowel Lymphoma and Chorea

2002 ◽  
Vol 95 (3) ◽  
pp. 133-134 ◽  
Author(s):  
T Kitiyakara ◽  
M Jackson ◽  
D A Gorard
Keyword(s):  
Small Bowel ◽  
Coeliac Disease ◽  
Refractory Coeliac Disease

scholarly journals Myoclonus ataxia and refractory coeliac disease

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Ptolemaios G Sarrigiannis ◽  
Nigel Hoggard ◽  
Daniel Aeschlimann ◽  
David S Sanders ◽  
Richard A Grünewald ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Refractory Coeliac Disease

Refractory coeliac disease

2020 ◽  
Vol 36 (3) ◽  
pp. 215-222
Author(s):  
Stefania Chetcuti Zammit ◽  
David S. Sanders ◽  
Reena Sidhu
Keyword(s):  
Coeliac Disease ◽  
Refractory Coeliac Disease

Refractory coeliac disease a reality: views from Pakistan

2016 ◽  
Vol 47 (1) ◽  
pp. 51-53
Author(s):  
Rajesh M Mandhwani ◽  
Rajesh K Wadhwa ◽  
Syed Mudassir Laeeq ◽  
Nasir Hasan Luck ◽  
Mohammad Mubarak ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Villous Atrophy ◽  
Immunosuppressive Agents ◽  
Signs And Symptoms ◽  
Intraepithelial Lymphocytes ◽  
Response To Treatment ◽  
Gluten Free ◽  
Refractory Celiac Disease ◽  
Small Intestinal ◽  
Refractory Coeliac Disease

Refractory coeliac disease (RCD) is described as persistence or recurrence of signs and symptoms of malabsorption with small-intestinal villous atrophy despite being on a strict gluten-free diet (GFD) for more than 12 months. RCD is a diagnosis of exclusion. There are two types of RCD, based upon the immunohistochemical features (presence of intraepithelial lymphocytes), response to treatment and prognosis. The treatment of RCD includes GFD and immunosuppressive agents. We hereby present a case of refractory celiac disease type II in a young man who later went on to develop Addisonian crisis and did not survive.

scholarly journals T-cell repertoires in refractory coeliac disease

Gut ◽  
2017 ◽  
pp. gutjnl-2016-311816 ◽  
Author(s):  
Julia Ritter ◽  
Karin Zimmermann ◽  
Korinna Jöhrens ◽  
Stefanie Mende ◽  
Anke Seegebarth ◽  
...  
Keyword(s):  
T Cell ◽  
Coeliac Disease ◽  
Refractory Coeliac Disease
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