HPV genotypes in cervical neoplasia in South Africa.

In 1992 Lorincz et al. were the first to evaluate the clinicopathologic correlation with 11 recently identified human papillomavirus (HPV) genotypes: 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, and 58. Using cervical samples from 8 studies that included specimens from 2627 women, HPV genotypes were categorized by the likelihood of association with grades of cervical neoplasia (from normal to cancer). These findings were the basis of the determination that (a) HPV causes cervical cancer, (b) detection of the cancer associated HPV genotypes could identify women at risk for cervical pre-cancer and cancer, and (c) a prophylactic HPV vaccine should include protection against (at least) HPV 16 and 18.

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Selecting HPV genotypes to optimize performance of GeneXpert and linear array in South Africa

Gynecologic Oncology ◽

10.1016/j.ygyno.2019.04.559 ◽

2019 ◽

Vol 154 ◽

pp. 242

Author(s):

L.G. Johnson ◽

R. Saidu ◽

Z. Mbulawa ◽

A.L. Williamson ◽

R. Boa ◽

...

Keyword(s):

South Africa ◽

Linear Array ◽

Hpv Genotypes

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Human papillomavirus genotyping using HPV DNA chip analysis in Korean women

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2007.00871.x ◽

2007 ◽

Vol 17 (2) ◽

pp. 497-501 ◽

Cited By ~ 19

Author(s):

H. S. Lee ◽

K. M. Kim ◽

S. M. Kim ◽

Y. D. Choi ◽

J. H. Nam ◽

...

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Cervical Neoplasia ◽

Dna Chip ◽

Korean Women ◽

Hpv 16 ◽

Hpv Dna ◽

Hpv Genotypes ◽

High Risk Hpv ◽

Chip Analysis

This study was designed to investigate the genotypes of human papillomavirus (HPV) in Korean women who had abnormal cervical cytology and to evaluate the clinical accuracy of HPV DNA chip analysis for the diagnosis of cervical neoplasia. Liquid-based cytology preparations, HPV DNA chip analysis, and cervical biopsy were performed in 2358 women. High-risk HPV was identified in 23.5% of 1650 histologically confirmed normal samples (including cervicitis and squamous metaplasia) and in 81.8% of 708 samples with cervical intraepithelial neoplasia (CIN) and carcinoma (P< 0.01). The major prevalent high-risk HPV genotypes in 381 samples of CIN II/III were HPV-16, -58, -33, and -31, in order of prevalence rate (average overall, 78.0%), and HPV-16, -18, -58, and -33 (average overall, 81.2%) in 133 samples of squamous cell carcinoma (SCC). The infection rate of HPV-16 was significantly higher than that of other high-risk HPV genotypes in all normal, CIN, and SCC cases (P< 0.01) and increased with more advanced squamous cervical lesions (P< 0.01). The detection accuracy of high-risk HPV using HPV DNA chip analysis for CIN II or worse was as follows: sensitivity 84% (81–87%), specificity 72% (70–74%), positive predictive value 47% (44–50%), and negative predictive value 94% (92–95%). These results suggest that HPV DNA chip analysis may be a reliable diagnostic tool for the detection of cervical neoplasia and that there are geographic differences in the distribution of high-risk HPV genotypes.

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Molecular variants of human papillomavirus type 16 and risk for cervical neoplasia in South Africa

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2006.00401.x ◽

2006 ◽

Vol 16 (2) ◽

pp. 736-742 ◽

Cited By ~ 10

Author(s):

J.J. TU ◽

L. KUHN ◽

L. DENNY ◽

K.J. BEATTIE ◽

A. LORINCZ ◽

...

Keyword(s):

South Africa ◽

Human Papillomavirus ◽

Cervical Neoplasia ◽

Human Papillomavirus Type 16 ◽

Molecular Variants

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High‐risk HPV genotypes in cervical neoplasias in Senegal; Respective prevalence of high‐risk HPVgenotypes in cervical neoplasia in Senegal

Journal of Medical Virology ◽

10.1002/jmv.27020 ◽

2021 ◽

Author(s):

Halimatou Diop‐Ndiaye ◽

Xavier Sastre‐Garau ◽

Aboubacry Drame ◽

Birama Dembele ◽

Nafissatou N. Ba ◽

...

Keyword(s):

High Risk ◽

Cervical Neoplasia ◽

Hpv Genotypes ◽

High Risk Hpv

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HPV genotypes in women with squamous intraepithelial lesions and normal cervixes participating in a community-based microbicide study in Pretoria, South Africa

Journal of Clinical Virology ◽

10.1016/j.jcv.2009.02.001 ◽

2009 ◽

Vol 44 (4) ◽

pp. 318-321 ◽

Cited By ~ 12

Author(s):

H.M. Said ◽

K. Ahmed ◽

R. Burnett ◽

B.R. Allan ◽

A.-L. Williamson ◽

...

Keyword(s):

South Africa ◽

Squamous Intraepithelial Lesions ◽

Community Based ◽

Hpv Genotypes ◽

Intraepithelial Lesions

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Characteristics of HSV-2, M.genitalium and C.trachomatis in HPV genotypes- associated Cervical Cancer and Genital Infections...

Infectious Disorders - Drug Targets ◽

10.2174/1871526520666191231142317 ◽

2019 ◽

Vol 20 ◽

Author(s):

Mona Moharreri ◽

Amir Sohrabi

Keyword(s):

Cervical Cancer ◽

High Risk ◽

Descriptive Study ◽

Cervical Neoplasia ◽

Genital Infections ◽

Common Cancer ◽

Hpv Genotypes ◽

Hpv Types ◽

Liquid Based Cytology ◽

High Risk Hpv

Background: Cervical cancer is the most common cancer in women. High Risk HPV types are known as the main agents involved in genital and cervical malignancies. There may be co pathogens like STDs that involved in enhancing the susceptibility and progression to cervical neoplasia. This study was conducted to detect HSV2, C.Trachomatis and M.Genitalium in women with and at the risk of cervical cancer related to HPV for defining their roles in facilitating and persistence of genital disorders. Materials and Methods: This descriptive study was performed on 195 Liquid Based Cytology (LBCs) specimens were collected from women referred to private laboratories. Fifty, 98 and 47 samples were from women with known cervical cancer, HPV positive and HPV negative, respectively. The HSV-2, C.trachomatis, M.genitalium and HPV genotypes have been detected using multiplex TaqMan Real Time PCR and PCR hybridization. Results: A total of 148 HPV positive samples, HPVs 6 (35.13%), 16 (32.43%), 18 (21.62%), 11 (9.46%), 31 (9.46%), and 51 (9.46%) were the most common genotypes. Single, 2, 3, and more than 4 multiple HPV genotypes were detected in 46%, 29.7%, 14.2%, 15 10.1% cases, respectively. The prevalence of M.genitalium, C.trachomatis and HSV2 was 3 (1.54%), 24 (12.3%) and 1(0.5%), respectively. There were no statistically significant differences between these pathogens and cervical cancer (p≥ 0.05). Conclusions: HR-HPV genotypes were more prevalent in genital infections and cervical cancer.

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