Association of asthma diagnosis with leptin and adiponectin: a systematic review and meta-analysis

2016 ◽  
Vol 65 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Lei Zhang ◽  
Yong Yin ◽  
Hao Zhang ◽  
Wenwei Zhong ◽  
Jing Zhang
Keyword(s):  
Systematic Review ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Controlled Trials ◽  
Asthma Diagnosis ◽  
Case Control Studies ◽  
Serum Leptin ◽  
Randomized Controlled ◽  
Study Population

There is some evidence which shows that higher levels of serum leptin and lower levels of serum adiponectin are associated with the diagnosis of asthma. This meta-analysis evaluated the association of serum leptin and adiponectin levels with the diagnosis of asthma. We searched the MEDLINE, Cochrane, EMBASE and CINAHL Plus databases up to July 2015. Eligible studies were randomized controlled trials, prospective studies, retrospective studies, case–control studies and cohort studies. 13 studies with 3642 patients were included in the study. The meta-analysis found that in the overall study population, the diagnosis of asthma was associated with higher levels of leptin (pooled standardized difference in means=0.867, 95% CI 0.416 to 1.318, p<0.001) and lower levels of adiponectin (pooled standardized difference in means=−0.371, 95% CI −0.728 to −0.014, p=0.042) in patients with asthma compared with controls. Subgroup analysis found that higher leptin levels were associated with asthma both in adults (standardized difference in means=1.374, 95% CI 0.621 to 2.126, p<0.001) and children (standardized difference in means=0.302, 95% CI 0.010 to 0.594, p=0.042). However, borderline association of adiponectin with asthma was seen in adults (p=0.05), but not in children (p=0.509). Sensitivity analysis indicated that the findings for leptin were robust. Our findings are consistent with higher levels of serum leptin being associated with asthma regardless of age, and low adiponectin levels being associated with asthma in adults only.

Abstract 12672: Post-Implantation Hematoma Increases Risk of Cardiac Implantable Electronic Device Infection: A Systematic Review and Meta-analysis

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Jakrin Kewcharoen ◽  
Chanavuth Kanitsoraphan ◽  
Sittinun Thangjui ◽  
Thiratest Leesutipornchai ◽  
Leenhapong Navaravong
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Electronic Device ◽  
Meta Analysis ◽  
Case Control ◽  
Cardiac Implantable Electronic Device ◽  
Case Control Studies ◽  
Randomized Controlled ◽  
Device Infection ◽  
Post Implantation

Introduction: Several studies have shown inconsistent relationship between post-implantation hematoma (PH) and cardiac implantable electronic device (CIED) infection. In this study, we performed a systematic review and meta-analysis to explore the effect of PH and the risk of CIED infection. Hypothesis: PH increases the risk of CIED infection. Methods: We searched the databases of MEDLINE and EMBASE from inception to March 2020. Included studies were cohort studies, case-control studies, cross-sectional studies and randomized controlled trials that reported incidence of PH and CIED infection during the follow-up period. CIED infection was defined as either a device-related local or systemic infection. Data from each study were combined using the random-effects, generic inverse variance method of Der Simonian and Laird to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: Fourteen studies from 2006 to 2018 were included, involving a total of 28,319 participants. There were 6 cohort studies, 7 case-control studies and 1 randomized controlled trial. In random-effect model, we found that PH significantly increases the risk of overall CIED infection (OR = 6.30, 95%CI: 3.87-10.24, I2=49.3%) (Figure 1). There was no publication bias observed in the funnel plot as well as no small-study effect observed in Egger’s test. Conclusions: Our meta-analysis demonstrated that PH significantly increases the risk of CIED infection. Precaution should be taken to during device implantation to reduce PH and subsequent CIED infection.

Types of trials

2017 ◽  
Author(s):  
Mark Harrison
Keyword(s):  
Emergency Medicine ◽  
Cohort Studies ◽  
Case Reports ◽  
Meta Analysis ◽  
Case Series ◽  
Case Control ◽  
Controlled Trials ◽  
Case Control Studies ◽  
Advantages And Disadvantages ◽  
Randomized Controlled

This chapter describes types of trials as applied to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details and advantages and disadvantages of case reports, case series, cohort studies, case–control studies, randomized controlled trials, crossover trials, systematic reviews, and meta-analysis. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.

scholarly journals Health effects of cow’s milk consumption in infants up to 3 years of age: a systematic review and meta-analysis

2015 ◽  
Vol 19 (2) ◽  
pp. 293-307 ◽  
Author(s):  
Ursula Griebler ◽  
Melanie U Bruckmüller ◽  
Christina Kien ◽  
Birgit Dieminger ◽  
Bettina Meidlinger ◽  
...  
Keyword(s):  
Health Effects ◽  
Meta Analysis ◽  
Case Control ◽  
Cow’S Milk ◽  
Controlled Trials ◽  
Milk Consumption ◽  
Case Control Studies ◽  
Deficiency Anaemia ◽  
Cow's Milk ◽  
Randomized Controlled

AbstractObjectiveTo summarize the best available evidence regarding the short- and long-term health effects of cow’s milk intake in healthy, full-term infants up to 3 years of age.DesignWe conducted a systematic review and meta-analysis.SettingWe searched MEDLINE (via PubMed), EMBASE and the Cochrane Library between 1960 and July 2013 and manually reviewed reference lists of pertinent articles. Two researchers independently reviewed abstracts and full-text articles and extracted relevant data.SubjectsWe included (randomized/non-randomized) controlled trials and observational studies.ResultsWe included data from twenty-three studies (one randomized controlled trial, four non-randomized controlled trials, eight case–control studies and ten cohort studies) for the evidence synthesis. Pooled results of four studies revealed a higher risk of Fe-deficiency anaemia for infants consuming cow’s milk compared with those consuming follow-on formula (relative risk=3·76; 95 % CI 2·73, 5·19). For type 1 diabetes mellitus, six out of seven case–control studies did not show a difference in the risk of developing this disease based on the age of introduction of cow’s milk. We did not find negative associations for other health effects.ConclusionsCow’s milk consumption in infancy is associated with an increased risk of developing Fe-deficiency anaemia. Limiting cow’s milk consumption may be important to ensure an adequate Fe intake for infants and toddlers. High-quality patient information for caregivers is needed on how infants’ Fe requirements can be met.

scholarly journals Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Baoqi Zeng ◽  
Le Gao ◽  
Qingxin Zhou ◽  
Kai Yu ◽  
Feng Sun
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Comprehensive Overview ◽  
Randomized Controlled ◽  
Vaccine Type ◽  
Alpha Beta ◽  
Alpha Variant

Background. It was urgent and necessary to synthesize the evidence for vaccine effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a systematic review and meta-analysis to provide a comprehensive overview of the effectiveness profile of COVID-19 vaccines against VOC. Methods. Published and preprinted randomized controlled trials (RCTs), cohort studies, and case-control studies that evaluated the VE against VOC (Alpha, Beta, Gamma, or Delta) were searched until 31 August 2021. Pooled estimates and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis. VE was defined as (1-estimate). Results. Seven RCTs (51,169 participants), 10 cohort studies (14,385,909 participants) and 16 case-control studies (734,607 cases) were included. Eight COVID-19 vaccines (mRNA-1273, BNT162b2, ChAdOx1, Ad26.COV2.S, NVX-CoV2373, BBV152, CoronaVac, and BBIBP-CorV) were included in this analysis. Full vaccination was effective against Alpha, Beta/Gamma, and Delta variants, with VE of 88.3% (95% CI, 82.4-92.2), 70.7% (95% CI, 59.9-78.5), and 71.6% (95% CI, 64.1-77.4), respectively. But partial vaccination was less effective, with VE of 59.0% (95% CI, 51.3-65.5), 49.3% (95% CI, 33.0-61.6), and 52.6% (95% CI, 43.3-60.4), respectively. mRNA vaccines seemed to have higher VE against VOC over others, significant interactions (pinteraction < 0.10) were observed between VE and vaccine type (mRNA vaccines vs. non-mRNA vaccines). Conclusions. Full vaccination of COVID-19 vaccines is highly effective against Alpha variant, and moderate effective against Beta/Gamma and Delta variants. Partial vaccination has less VE against VOC. mRNA vaccines seem to have higher VE against Alpha, Beta/Gamma, and Delta variants over others.

The effect of l-carnitine supplementation on serum leptin concentrations: a systematic review and meta-analysis of randomized controlled trials

Endocrine ◽  
2018 ◽  
Vol 60 (3) ◽  
pp. 386-394 ◽  
Author(s):  
Ali Nazary-vannani ◽  
Ehsan Ghaedi ◽  
Seyed Mohammad Mousavi ◽  
Alireza Teymouri ◽  
Jamal Rahmani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Carnitine Supplementation ◽  
Serum Leptin ◽  
Randomized Controlled
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