AUTOLOGOUS MESENCHYMAL STEM CELLS FOR THE TREATMENT OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS: AN OPEN–LABEL PHASE 2A PROOF–OF–CONCEPT STUDY

Peter Connick; Siddharthan Chandran

doi:10.1136/jnnp-2013-306573.25

AUTOLOGOUS MESENCHYMAL STEM CELLS FOR THE TREATMENT OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS: AN OPEN–LABEL PHASE 2A PROOF–OF–CONCEPT STUDY

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2013-306573.25 ◽

2013 ◽

Vol 84 (11) ◽

pp. e2.140-e2

Author(s):

Peter Connick ◽

Siddharthan Chandran

Keyword(s):

Multiple Sclerosis ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Progressive Multiple Sclerosis ◽

Proof Of Concept ◽

Open Label ◽

Concept Study ◽

Secondary Progressive ◽

Open Label Phase ◽

Autologous Mesenchymal Stem Cells

Download Full-text

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

The Lancet Neurology ◽

10.1016/s1474-4422(11)70305-2 ◽

2012 ◽

Vol 11 (2) ◽

pp. 150-156 ◽

Cited By ~ 356

Author(s):

Peter Connick ◽

Madhan Kolappan ◽

Charles Crawley ◽

Daniel J Webber ◽

Rickie Patani ◽

...

Keyword(s):

Multiple Sclerosis ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Progressive Multiple Sclerosis ◽

Proof Of Concept ◽

Open Label ◽

Concept Study ◽

Secondary Progressive ◽

Open Label Phase ◽

Autologous Mesenchymal Stem Cells

Download Full-text

Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study

PLoS ONE ◽

10.1371/journal.pone.0195891 ◽

2018 ◽

Vol 13 (5) ◽

pp. e0195891 ◽

Cited By ~ 41

Author(s):

Oscar Fernández ◽

Guillermo Izquierdo ◽

Victoria Fernández ◽

Laura Leyva ◽

Virginia Reyes ◽

...

Keyword(s):

Multiple Sclerosis ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Phase I ◽

Feasibility Study ◽

Progressive Multiple Sclerosis ◽

Secondary Progressive Multiple Sclerosis ◽

Secondary Progressive

Download Full-text

Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Secondary Progressive Multiple Sclerosis

Journal of Stem Cell Research & Therapy ◽

10.4172/2157-7633.s6-002 ◽

2013 ◽

Author(s):

Xu J Zhang Z

Keyword(s):

Multiple Sclerosis ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Umbilical Cord ◽

Progressive Multiple Sclerosis ◽

Secondary Progressive Multiple Sclerosis ◽

Human Umbilical Cord ◽

Secondary Progressive

Download Full-text

In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET

Journal of Neuroinflammation ◽

10.1186/s12974-018-1352-9 ◽

2018 ◽

Vol 15 (1) ◽

Cited By ~ 11

Author(s):

Marloes H. J. Hagens ◽

Sandeep V. Golla ◽

Martijn T. Wijburg ◽

Maqsood Yaqub ◽

Dennis Heijtel ◽

...

Keyword(s):

Multiple Sclerosis ◽

Progressive Multiple Sclerosis ◽

Proof Of Concept ◽

Concept Study ◽

In Vivo Assessment

Download Full-text

A proof-of-concept study assessing the potential of allogeneic chondrogenic induced mesenchymal stem cells as a treatment for osteoarthritis in the horse

Equine Veterinary Journal ◽

10.1111/evj.23_13008 ◽

2018 ◽

Vol 50 ◽

pp. 15-16

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Proof Of Concept ◽

Concept Study

Download Full-text

Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial

Urologia Internationalis ◽

10.1159/000492120 ◽

2018 ◽

Vol 101 (3) ◽

pp. 358-365 ◽

Cited By ~ 23

Author(s):

Saddam Al Demour ◽

Hanan Jafar ◽

Sofia Adwan ◽

Abedallatif AlSharif ◽

Hussam Alhawari ◽

...

Keyword(s):

Clinical Trial ◽

Stem Cells ◽

Bone Marrow ◽

Mesenchymal Stem Cells ◽

Erectile Dysfunction ◽

Autologous Bone Marrow ◽

Diabetic Patients ◽

Open Label ◽

Open Label Phase ◽

Autologous Bone

Download Full-text

CT-04 Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cells (MSCs) in patients with systemic lupus erythematosus: results of an open-label phase I study

10.1136/lupus-2018-lsm.76 ◽

2018 ◽

Cited By ~ 2

Author(s):

Diane L Kamen ◽

Paul J Nietert ◽

Hongjun Wang ◽

Tara Duke ◽

Colleen Cloud ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Phase I ◽

Lupus Erythematosus ◽

Phase I Study ◽

Systemic Lupus ◽

Open Label ◽

Safety And Efficacy ◽

Open Label Phase

Download Full-text

The antiproliferative effect of pasireotide LAR alone and in combination with everolimus (RAD001) in patients with progressive medullary thyroid cancer (MTC): A single-center, open-label, phase II, proof-of-concept study.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.tps219 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. TPS219-TPS219

Author(s):

A. Faggiano ◽

A. Colao

Keyword(s):

Thyroid Cancer ◽

Phase Ii ◽

Medullary Thyroid Cancer ◽

Antiproliferative Effect ◽

Proof Of Concept ◽

Single Center ◽

Open Label ◽

Medullary Thyroid ◽

Concept Study ◽

Open Label Phase

Download Full-text

Therapeutic Application of Autologous ADMSCS (Adipose Derived Mesenchymal Stem Cells) and Islet like Cell Aggregates (ICAS) Derived from them in Type 1 and 2 Diabetes Mellitus - A Proof of Concept Study

Stem Cells Research Development & Therapy ◽

10.24966/srdt-2060/100008 ◽

2016 ◽

Vol 3 (1) ◽

pp. 1-6

Author(s):

Anant Marathe ◽

Keyword(s):

Diabetes Mellitus ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Cell Aggregates ◽

Proof Of Concept ◽

Therapeutic Application ◽

Concept Study

Download Full-text

A novel therapeutic combination of mesenchymal stem cells and stigmasterol to attenuate osteoarthritis in rodent model system— a proof of concept study

Stem Cell Investigation ◽

10.21037/sci-2020-048 ◽

2021 ◽

Vol 8 ◽

pp. 5-5

Author(s):

Samuel Joshua Pragasam Sampath ◽

Nagasuryaprasad Kotikalapudi ◽

Vijayalakshmi Venkatesan

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Model System ◽

Rodent Model ◽

Proof Of Concept ◽

Concept Study ◽

System A ◽

Novel Therapeutic

Download Full-text