scholarly journals Addressing ethical challenges in HIV prevention research with people who inject drugs

2016 ◽  
Vol 44 (3) ◽  
pp. 149-158 ◽  
Author(s):  
Liza Dawson ◽  
Steffanie A Strathdee ◽  
Alex John London ◽  
Kathryn E Lancaster ◽  
Robert Klitzman ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
People Who Inject Drugs ◽  
Standard Of Care ◽  
Prevention Research ◽  
Hiv Incidence ◽  
Ethical Challenges ◽  
Call To Action ◽  
Research Findings ◽  
Basic Services ◽  
Background Risks

Despite recent advances in HIV prevention and treatment, high HIV incidence persists among people who inject drugs (PWID). Difficult legal and political environments and lack of services for PWID likely contribute to high HIV incidence. Some advocates question whether any HIV prevention research is ethically justified in settings where healthcare system fails to provide basic services to PWID and where implementation of research findings is fraught with political barriers. Ethical challenges in research with PWID include concern about whether research evidence will be translated into practice; concerns that research might exacerbate background risks; and ethical challenges regarding the standard of HIV prevention in research. While these questions arise in other research settings, for research with PWID, these questions are especially controversial. This paper analyses four ethical questions in determining whether research could be ethically acceptable: (1) Can researchers ensure that research does not add to the burden of social harms and poor health experienced by PWID? (2) Should research be conducted in settings where it is uncertain whether research findings will be translated into practice? (3) When best practices in prevention and care are not locally available, what standard of care and prevention is ethically appropriate? (4) Does the conduct of research in settings with oppressive policies constitute complicity? We outline specific criteria to address these four ethical challenges. We also urge researchers to join the call to action for policy change to provide proven safe and effective HIV prevention and harm reduction interventions for PWID around the world.

Ethical Challenges in International HIV Prevention Research

2004 ◽  
Vol 11 (1) ◽  
pp. 49-61 ◽  
Author(s):  
Kathleen MacQueen ◽  
Katharine Shapiro ◽  
Quarraisha Karim ◽  
Jeremy Sugarman
Keyword(s):  
Hiv Prevention ◽  
Prevention Research ◽  
Ethical Challenges

scholarly journals Cross-Sectional HIV Incidence Estimation in HIV Prevention Research

2013 ◽  
Vol 63 ◽  
pp. S233-S239 ◽  
Author(s):  
Ron Brookmeyer ◽  
Oliver Laeyendecker ◽  
Deborah Donnell ◽  
Susan H. Eshleman
Keyword(s):  
Hiv Prevention ◽  
Prevention Research ◽  
Hiv Incidence ◽  
Cross Sectional ◽  
Incidence Estimation

scholarly journals HIV prevention research and COVID-19: putting ethics guidance to the test

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Stuart Rennie ◽  
Wairimu Chege ◽  
Leah A. Schrumpf ◽  
Florencia Luna ◽  
Robert Klitzman ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Ethical Issues ◽  
Risk Mitigation ◽  
Research Priorities ◽  
Responsible Conduct Of Research ◽  
Main Body ◽  
Guidance Document ◽  
Prevention Research ◽  
Ethical Challenges ◽  
Care Needs

Abstract Background Critical public health measures implemented to mitigate the spread of the novel coronavirus disease (COVID-19) pandemic have disrupted health research worldwide, including HIV prevention research. While general guidance has been issued for the responsible conduct of research in these challenging circumstances, the contours of the dueling COVID-19 and HIV/AIDS pandemics raise some critical ethical issues for HIV prevention research. In this paper, we use the recently updated HIV Prevention Trials Network (HPTN) Ethics Guidance Document (EGD) to situate and analyze key ethical challenges related to the conduct of HIV prevention research during the COVID-19 pandemic as well as identify potential areas for refinement of the guidance document based on this unprecedented state of affairs. Main body Necessary actions taken for HIV prevention research studies due to the COVID-19 pandemic involve an array of ethical issues including those related to: (1) risk mitigation; (2) behavior change; (3) compounding vulnerability; (4) community engagement; (5) trial reopening; and 6) shifting research priorities. Conclusions In the context of the dueling HIV and COVID-19 global pandemics, research teams and sponsors must be nimble in responding to the rapidly changing environment by being sensitive to the associated ethical issues. The HTPN EGD provides a rich set of tools to help identify, analyze and address many of these issues. At the same time, future refinements of the HPTN EGD and other research ethics guidance could be strengthened by providing explicit advice regarding the ethical issues associated with disrupted research and the reopening of studies. In addition, additional consideration should be given to appropriately balancing domains of risk (e.g., physical versus social), addressing the vulnerability of research staff and community partners, and responding to un-anticipatable ancillary care needs of participants and communities. Appropriately addressing these issues will necessitate conceptual work, which would benefit from the careful documentation of the actual ethical issues encountered in research, the strategies implemented to overcome them, and their success in doing so. Throughout all of these efforts, it is critical to remember that the HIV pandemic not be forgotten in the rush to deal with the COVID-19 pandemic.

scholarly journals Recruiting vulnerable populations to participate in HIV prevention research: findings from the Together 5000 cohort study

2019 ◽  
Vol 35 ◽  
pp. 4-11 ◽  
Author(s):  
Christian Grov ◽  
Drew A. Westmoreland ◽  
Pedro B. Carneiro ◽  
Matthew Stief ◽  
Caitlin MacCrate ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hiv Prevention ◽  
Vulnerable Populations ◽  
Prevention Research ◽  
Research Findings

scholarly journals Ethical issues in HIV prevention research with people who inject drugs

2013 ◽  
Vol 11 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Jeremy Sugarman ◽  
Scott M Rose ◽  
David Metzger
Keyword(s):  
Hiv Prevention ◽  
People Who Inject Drugs ◽  
Ethical Issues ◽  
Prevention Research

scholarly journals Reported Participation Benefits in International HIV Prevention Research with People Who Inject Drugs

2019 ◽  
Vol 41 (5) ◽  
pp. 28-34
Author(s):  
Jeremy Sugarman ◽  
Ilana Trumble ◽  
Erica Hamilton ◽  
Riza Sarasvita ◽  
Kostyantyn Dumchev ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
People Who Inject Drugs ◽  
Prevention Research

Championing Change to Save Lives: A Call to Action to Implement Reforms to Increase Use of Medications to Treat Opioid Use Disorder in Correctional Settings

2020 ◽  
pp. 073401682098162
Author(s):  
Sonia L. Canzater ◽  
Regina M. LaBelle
Keyword(s):  
Standard Of Care ◽  
Opioid Use Disorder ◽  
Correctional Facilities ◽  
Evidence Based ◽  
Opioid Use ◽  
Call To Action ◽  
Evidence Based Treatment ◽  
High Prevalence ◽  
Correctional Settings ◽  
Overdose Deaths

The disproportional rates of opioid use disorder (OUD) in U.S. correctional facilities make them prime intervention points to treat OUD utilizing medication to treat opioid use disorder (MOUD), the evidence-based clinical standard of care. MOUD has been shown to be effective to support recovery and reduce recurrence of OUD, overdose deaths, and recidivism for justice-involved persons both while incarcerated and once they reenter their communities. Despite the high prevalence, most jails and prisons do not offer MOUD. Litigation has spurred expanded access in more facilities, but widespread MOUD access can only become a reality through a comprehensive effort of corrections officials, medical experts, advocates, legislators, and other champions to raise awareness and affect ideological and policy change. It is a legal and ethical imperative that the lives of justice-involved persons not be jeopardized by the lack of evidence-based treatment for OUD in correctional settings.

Sign in / Sign up

Export Citation Format

Share Document