Response to letter to editor regarding ‘Anatomical characterization of the inferior petrosal sinus and adjacent cerebellopontine angle cistern for development of an endovascular transdural cerebrospinal fluid shunt’

Background and purposeWe evaluated the inferior petrosal sinus (IPS) and adjacent cerebellopontine angle (CPA) cistern as a potential implantation site for a novel venous endovascular transdural CSF shunt concept to treat communicating hydrocephalus. We analyzed the dimensions of the IPS, CPA cistern, and distances to adjacent neurovascular structures.Materials and methodsGadolinium enhanced T1 weighted brain MRI datasets of 36 randomly selected patients, aged 20–80 years, were analyzed with three-dimensional multiplanar reconstruction to measure IPS diameter and length, CPA cistern depth, and IPS proximity to the vertebrobasilar arteries and brainstem. Statistical analysis was used to assess gender, sidedness, and age dependence.ResultsMean IPS diameter ranged from 2.27 mm to 3.31 mm at three axial levels, with >90% larger than 1.46 mm. CPA cistern adjacent to the IPS exhibited a mean depth of 3.86 mm to 7.39 mm between the dura and brainstem at corresponding axial levels. There was no side dependence except for a longer distance from the IPS to the basilar artery on the left compared with the right (9.72 vs 7.28, P<0.019). Linear regression analysis showed that the distance from the IPS to the brainstem was statistically significantly increased with age (P<0.0002) and was greater in men, with little side variation (P=0.524).ConclusionOur results demonstrate sufficient CSF CPA cisternal space adjacent to the IPS and support the feasibility of an endovascular catheter delivered transdural implantable shunt. Such a device could serve to mimic the function of the arachnoid granulation by establishing a regulated path for CSF flow from the intracranial subarachnoid space to the venous system and provide a treatment for communicating hydrocephalus.

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Characterization of clinically significant isolates ofStaphylococcus epidermidisfrom patients with cerebrospinal fluid shunt infections

Epidemiology and Infection ◽

10.1017/s0950268800067510 ◽

1991 ◽

Vol 106 (3) ◽

pp. 467-475 ◽

Cited By ~ 6

Author(s):

J. Etienne ◽

B. Charpin ◽

J. Grando ◽

Y. Brun ◽

M. Bes ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Restriction Analysis ◽

Cerebrospinal Fluid Shunt ◽

Extrachromosomal Dna ◽

Dna Restriction ◽

Total Dna ◽

Resistant Strains ◽

Clinically Significant ◽

Shunt Infections

SUMMARYBiotyping, slime production, antibiograms, extrachromosomal DNA banding and total DNA restriction analysis were used to characterizeStaphylococcus epidermidisstrains causing cerebrospinal fluid shunt infections in 11 patients. Infections considered to be community acquired and those acquired in the first 2 weeks of hospital admission were due to oxacillin-susceptible isolates. Multiply resistant strains were isolated from patients who were in hospital for more than 1 month before tube implantation. Slime was detected in staphylococci for 54% of cases, but its expression varied. Strains from different patients could be differentiated from one another by the extrachromosomal DNA bandings and total DNA restriction patterns, but isolates from the same patient were usually similar. During the period of external drainage, epidemiological markers were useful in differentiating persistence of infection from contamination or re-infection by a new strain.

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109 Development of an Endovascular Transvenous Delivery System for Implantation of an Inferior Petrosal Sinus Transdural Cerebrospinal Fluid Shunt

Neurosurgery ◽

10.1093/neuros/nyy303.109 ◽

2018 ◽

Vol 65 (CN_suppl_1) ◽

pp. 83-83

Author(s):

Adel M Malek ◽

Carl B Heilman

Keyword(s):

Cerebrospinal Fluid ◽

Delivery System ◽

Inferior Petrosal Sinus ◽

Cerebrospinal Fluid Shunt

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Faculty Opinions recommendation of Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717597900.793476740 ◽

2013 ◽

Author(s):

Laetitia Davidovic

Keyword(s):

Cerebrospinal Fluid ◽

Human Cerebrospinal Fluid

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Mechanical complications of cerebrospinal fluid shunt. Differences between adult and pediatric populations: myths or reality?

Child s Nervous System ◽

10.1007/s00381-021-05125-8 ◽

2021 ◽

Author(s):

Guillaume Coll ◽

Francis Abed Rabbo ◽

Emmanuel de Schlichting ◽

Aurélien Coste ◽

Jean Chazal ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Cerebrospinal Fluid Shunt ◽

Mechanical Complications ◽

Pediatric Populations

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In-depth Characterization of the Cerebrospinal Fluid (CSF) Proteome Displayed Through the CSF Proteome Resource (CSF-PR)

Molecular & Cellular Proteomics ◽

10.1074/mcp.m114.038554 ◽

2014 ◽

Vol 13 (11) ◽

pp. 3152-3163 ◽

Cited By ~ 86

Author(s):

Astrid Guldbrandsen ◽

Heidrun Vethe ◽

Yehia Farag ◽

Eystein Oveland ◽

Hilde Garberg ◽

...

Keyword(s):

Cerebrospinal Fluid

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The orthopedic characterization of cfap298tm304 mutants validate zebrafish to faithfully model human AIS

Scientific Reports ◽

10.1038/s41598-021-86856-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Marie-Hardy Laura ◽

Cantaut-Belarif Yasmine ◽

Pietton Raphaël ◽

Slimani Lotfi ◽

Pascal-Moussellard Hugues

Keyword(s):

Cerebrospinal Fluid ◽

Three Dimensional ◽

Fluid Circulation ◽

Micro Computed Tomography ◽

Csf Flow ◽

Cerebrospinal Fluid Circulation ◽

Clinical Criteria ◽

Brain And Spinal Cord ◽

The Brain

AbstractCerebrospinal fluid (CSF) circulation relies on the beating of motile cilia projecting in the lumen of the brain and spinal cord cavities Mutations in genes involved in cilia motility disturb cerebrospinal fluid circulation and result in scoliosis-like deformities of the spine in juvenile zebrafish. However, these defects in spine alignment have not been validated with clinical criteria used to diagnose adolescent idiopathic scoliosis (AIS). The aim of this study was to describe, using orthopaedic criteria the spinal deformities of a zebrafish mutant model of AIS targeting a gene involved in cilia polarity and motility, cfap298tm304. The zebrafish mutant line cfap298tm304, exhibiting alteration of CSF flow due to defective cilia motility, was raised to the juvenile stage. The analysis of mutant animals was based on micro-computed tomography (micro-CT), which was conducted in a QUANTUM FX CALIPER, with a 59 µm-30 mm protocol. 63% of the cfap298tm304 zebrafish analyzed presented a three-dimensional deformity of the spine, that was evolutive during the juvenile phase, more frequent in females, with a right convexity, a rotational component and involving at least one dislocation. We confirm here that cfap298tm304 scoliotic individuals display a typical AIS phenotype, with orthopedic criteria mirroring patient’s diagnosis.

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