The Natural History of Disease

1936 ◽  
Vol 12 (127) ◽  
pp. 203-204
Keyword(s):  
Natural History ◽  
History Of Disease ◽  
History Of

scholarly journals REVIEW ON THE CONCEPT OF SHAT KRIYAKALA

2022 ◽  
Vol 12 (6) ◽  
pp. 56-60
Author(s):  
Anu P Baby ◽  
Jigeesh PP
Keyword(s):  
Natural History ◽  
Early Stage ◽  
Disease Process ◽  
Pathological Process ◽  
Stage Of Development ◽  
Long Run ◽  
History Of Disease ◽  
Accurate Treatment ◽  
Current Scenario ◽  
History Of

Diagnosis in Ayurveda is not always in terms of the name of the disease but in terms of the nature or phenomenon. This phenomenon is described in terms of Samprapti of the disease in each patient, comprising Dosha, Dushya and Adhishtana components. The prime factors in the pathogenesis of the disease are Dosha and Dushya. Shat kriyakala refers to the stage of development of a pathological process in which a physician can intervene by the most accurate treatment modality and medicine, thereby halting the progression of the disease process. By intricate understanding of the process of Shat kriyakala, the disease process could be arrested, and further complications can be avoided. In the current scenario, the concept of prevention has become broad-based. The natural history of disease is one of the significant elements of epidemiology. The course of a disease takes in individual people from its pathological onset until its eventual resolution. Natural history of disease is possible to correlate pre-pathogenesis with Sanchaya, Prakopa, Prasara and pathogenesis with Sthanasamsraya, Vyakti and Bhedavastha of Shat kriyakala. Recent studies have shown that it is possible to identify certain pre-clinical stages for many diseases like Parkinson’s disease, which can help in the early successful treatment. Shat kriyakala helps to arrest the disease process at the very early stage itself. Along with current technology, the need for research for validating the Shat kriyakala will benefit humankind in the long run.

scholarly journals Su1463 – Natural History of Disease Progression and Interventions After Aborted Pancreatoduodenectomy for Pancreatic Adenocarcinoma

2019 ◽  
Vol 156 (6) ◽  
pp. S-1445
Author(s):  
Timothy J. Vreeland ◽  
Timothy E. Newhook ◽  
Laura R. Prakash ◽  
Whitney L. Dewhurst ◽  
Morgan L. Bruno ◽  
...  
Keyword(s):  
Natural History ◽  
Disease Progression ◽  
Pancreatic Adenocarcinoma ◽  
History Of Disease ◽  
History Of

scholarly journals Novel Therapies in Glioblastoma

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
James Perry ◽  
Masahiko Okamoto ◽  
Michael Guiou ◽  
Katsuyuki Shirai ◽  
Allison Errett ◽  
...  
Keyword(s):  
Natural History ◽  
Molecular Biology ◽  
Targeted Therapies ◽  
Conventional Treatment ◽  
Tumor Biology ◽  
Treatment Resistance ◽  
Novel Therapies ◽  
History Of Disease ◽  
History Of ◽  
Poor Outcomes

Conventional treatment of glioblastoma has advanced only incrementally in the last 30 years and still yields poor outcomes. The current strategy of surgery, radiation, and chemotherapy has increased median survival to approximately 15 months. With the advent of molecular biology and consequent improved understanding of basic tumor biology, targeted therapies have become cornerstones for cancer treatment. Many pathways (RTKs, PI3K/AKT/mTOR, angiogenesis, etc.) have been identified in GBM as playing major roles in tumorigenesis, treatment resistance, or natural history of disease. Despite the growing understanding of the complex networks regulating GBM tumors, many targeted therapies have fallen short of expectations. In this paper, we will discuss novel therapies and the successes and failures that have occurred. One clear message is that monotherapies yield minor results, likely due to functionally redundant pathways. A better understanding of underlying tumor biology may yield insights into optimal targeting strategies which could improve the overall therapeutic ratio of conventional treatments.

Sign in / Sign up

Export Citation Format

Share Document