Changes in the corrected QT interval and corrected QT dispersion during haemodialysis

Abstract Background Carbon monoxide causes electrical, functional, and morphological changes in the heart. It is unclear, however, whether the indicators of myocardial damage can predict the patient’s prognosis after carbon monoxide poisoning. This retrospective study aimed to investigate the relationship between the carboxyhemoglobin level and electrocardiographic (ECG) changes and whether the ECG changes and troponin I levels are related to the patient’s prognosis after carbon monoxide poisoning. Methods Carboxyhemoglobin, troponin I, and ECG parameters were measured in 70 patients with carbon monoxide poisoning. The QT and RR intervals were measured for each ECG lead in all patients, and the corrected QT interval and corrected QT dispersion were calculated. Results The correlation between the maximum corrected QT interval and the carboxyhemoglobin level was significant (P = 0.0072, R2 = 0.1017), as were the relationships between QT dispersion and carboxyhemoglobin (P < 0.001, R2 = 0.2358) and the corrected QT dispersion and carboxyhemoglobin (P < 0.001, R2 = 0.2613). The multivariate logistic analysis showed that the significant predictors of sequential disability were corrected QT dispersion (P = 0.0042), and troponin I level (P = 0.0021). Conclusions Patients’ prognosis following carbon monoxide poisoning can be predicted based on corrected QT dispersion and the troponin I level. Patients with myocardial damage should be monitored not only for their cardiovascular outcome but also for their neurological outcome and their prognosis.

Download Full-text

Change of the main parameters of 24-hour ekg monitoring in patients with myocardial infarction associated with ventricular arrhythmias

Kazan medical journal ◽

10.17816/kmj1583 ◽

2013 ◽

Vol 94 (2) ◽

pp. 176-180

Author(s):

I V Logacheva ◽

N G Barantseva

Keyword(s):

Myocardial Infarction ◽

Ventricular Arrhythmia ◽

Qt Interval ◽

Ventricular Arrhythmias ◽

Heart Rhythm ◽

Qt Dispersion ◽

Heart Rhythm Variability ◽

Corrected Qt Interval ◽

Grade 3 ◽

Q Wave

Aim. To study the change of the main parameters of 24-hour EKG monitoring over time in patients with myocardial infarction associated with ventricular arrhythmias of different grades. Methods. The change of the echocardiography parameters, heart rhythm variability, corrected QT interval duration and dispersion, late ventricular potentials, heart rhythm turbulence were examined in 70 adult men (mean age 52.6±1.3 years) with primary Q-wave myocardial infarction on 10-14th day of the disease and after 6 months. Patients were assigned into 3 groups depending on ventricular arrhythmias severity (according to Lown classification modified by Ryan): А1 (n=29) - grade 1-2, А2 (n=23) - grade 3-4, А3 (n=18) - patients with paroxysmal ventricular tachycardia. Results. Presence of late ventricular potentials and pathologic heart rhythm turbulence in patients in acute period of myocardial infarction suggested high grade of ventricular arrhythmia. Ventricular arrhythmias were associated with severe sympathicotonia, prolongation of corrected QT interval and QT dispersion. 6 months after Q-wave myocardial infarction an autonomic imbalance increased and no positive changes of myocardial homogenicity parameters, late ventricular potentials and pathologic heart rhythm turbulence were observed with increasing ventricular arrhythmia grading and heart rate frequency. A relationship between left ventricle ejection fraction, myocardium mass and myocardial electric non-stability values was revealed. In patients with Q-wave myocardial infarction ventricular arrhythmias are mediated by several mechanisms: systolic and autonomic disorder, repolarization abnormalities, late ventricular potentials pathologic heart rhythm turbulence. The severity of abnormalities is marked by the ventricular arrhythmias grade. Conclusion. 6 months after myocardial infarction (in healing stage) the significant positive changes are found only in patients with 1-2 grades ventricular arrhythmias. The significant non-homogeneity of myocardial electrophysiological features still persists in patients with life-threatening ventricular arrhythmias.

Download Full-text

Corrected QT interval and QT dispersion in temporal lobe epilepsy

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-020-00257-1 ◽

2021 ◽

Vol 57 (1) ◽

Author(s):

Maram Samy Nasef ◽

Ahmed Abdelmonem Gaber ◽

Yousry Aboelnaga Abdelhamid ◽

Islam Bastawy ◽

Salem Taha Abdelhady ◽

...

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Qt Interval ◽

Heart Rhythm ◽

Qt Dispersion ◽

Control Group ◽

Temporal Epilepsy ◽

Corrected Qt Interval ◽

Patients With Epilepsy ◽

Age And Sex

Abstract Background Cardiac arrhythmias are expected among patients with epilepsy due to the effect of anti-epileptic drugs. Temporal lobe epilepsy also causes autonomic seizures that may affect heart rhythm. Prolongation of the corrected QT interval and QT dispersion is a risk factor for cardiac arrhythmia. Objectives We aimed to assess corrected QT interval and QT dispersion in patients with epilepsy and if there is a difference between patients with temporal epilepsy versus non-temporal epilepsy. Methods This study was conducted on 100 patients (50 patients with temporal epilepsy and 50 patients with non-temporal epilepsy) and 50 age- and sex-matched healthy controls. They underwent a prolonged (6 to 24 h) 22 channel computerized electroencephalogram monitor with a 10–20 system. QT dispersion, QT interval, and corrected QT interval (using Bazett’s formula) were calculated. Results This study showed significantly higher QT dispersion and corrected QT interval in patients with epilepsy when compared to the age- and sex-matched control group (P < 0.001, P < 0.001). Also, the corrected QT interval and QT dispersion were significantly higher in temporal epilepsy patients when compared to the non-temporal group (P < 0.001, P < 0.001). Conclusion Corrected QT interval and QT dispersion are higher in epileptic patients and more among temporal epilepsy patients in comparison to non-temporal epilepsy patients.

Download Full-text

QT interval and corrected QT interval in patients with sepsis in correlation with sepsis outcome and electrolytes

QJM ◽

10.1093/qjmed/hcaa039.77a ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

A M Fahmy ◽

M M Abdelfattah ◽

R M Hashim ◽

M M A Aboali

Keyword(s):

Qt Interval ◽

Randomized Study ◽

Signs And Symptoms ◽

Qt Dispersion ◽

Qtc Interval ◽

Corrected Qt Interval ◽

Hospital Outcome ◽

Threatening Condition ◽

Life Threatening ◽

Specific Symptoms

Abstract Background sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. Common signs and symptoms of sepsis include fever, increased heart rate, increased breathing rate, and confusion. In the very young, old, and people with a weakened immune system, there may be no specific symptoms. Aim to study QT dispersion, QT interval abnormalities and corrected QT interval in septic patients in correlation with arrhythmias, hospital outcome (survival, mortality) and electrolytes. Patients and Methodology this is a prospective randomized study that was conducted on forty adult patients who were admitted in the ICU at Ahmed Maher Teaching Hospital with the diagnosis of sepsis to correlate Corrected QT interval (QTc) and QT dispersion (QTD) with arrhythmias, need for mechanical ventilation (MV), electrolytes and hospital outcome. Results forty patients were included in this study, their ages with a mean of 53.50± 13.7 years. Male patients were 24(60%) and female patients were 16 (40%). The most frequent risk factor was hypertension (62.5%). Conclusions the QTc duration may act as a risk marker in the septic patient. Patients with markedly prolonged QTc interval had significantly more episodes of inhospital ventricular tachycardia and hospital mortality. Recommendations QTc may add a useful, simple and accessible tool to be used in risk stratification of septic patients. Factors that cause QTc prolongation could be an avoidable or correctable factors; lifethreatening arrhythmia could be prevented.

Download Full-text

Can Indices of Myocardial Damage Predict Carbon Monoxide Poisoning Outcomes?

10.21203/rs.3.rs-84717/v1 ◽

2020 ◽

Author(s):

Hitoshi Koga ◽

Hideki Tashiro ◽

Kouta Mukasa ◽

Tomohiro Inoue ◽

Aya Okamoto ◽

...

Keyword(s):

Carbon Monoxide ◽

Qt Interval ◽

Troponin I ◽

Morphological Changes ◽

Carbon Monoxide Poisoning ◽

Myocardial Damage ◽

Qt Dispersion ◽

Ecg Changes ◽

Corrected Qt Interval ◽

Logistic Analysis

Abstract Background: Carbon monoxide causes electrical, functional, and morphological changes in the heart. It is not clear, however, whether the indices of myocardial damage can predict the patient’s prognosis after carbon monoxide poisoning. This retrospective study aimed to investigate the relation between the carboxyhemoglobin level and electrocardiographic (ECG) changes and whether the ECG changes and troponin I levels are related to the patient’s prognosis after carbon monoxide poisoning.Results: Carboxyhemoglobin, troponin I, and ECG parameters were measured in 70 patients with carbon monoxide poisoning. The QT and RR intervals were measured for each ECG lead in all patients, and the corrected QT interval and corrected QT dispersion were calculated. The correlation between the maximum corrected QT interval and the carboxyhemoglobin level was significant (P=0.0072, R2=0.1017), as were the relationships between QT dispersion and carboxyhemoglobin (P<0.001, R2=0.2358) and the corrected QT dispersion and carboxyhemoglobin (P<0.001, R2=0.2613). The multivariate logistic analysis showed that the significant predictors of sequential disability were hyperbaric oxygen therapy (P=0.0182), corrected QT dispersion (P=0.0062), and troponin I level (P=0.0002).Conclusions: Patients’ prognosis following carbon monoxide poisoning can be predicted based on corrected QT dispersion and the troponin I level. Patients with myocardial damage should be monitored not only for their cardiovascular outcome but also for their neurological outcome and their prognosis.

Download Full-text

Can indices of myocardial damage predict carbon monoxide poisoning outcomes?

10.21203/rs.3.rs-43628/v1 ◽

2020 ◽

Author(s):

Hitoshi Koga ◽

Hideki Tashiro ◽

Kouta Mukasa ◽

Tomohiro Inoue ◽

Aya Okamoto ◽

...

Keyword(s):

Carbon Monoxide ◽

Qt Interval ◽

Troponin I ◽

Morphological Changes ◽

Carbon Monoxide Poisoning ◽

Myocardial Damage ◽

Qt Dispersion ◽

Ecg Changes ◽

Corrected Qt Interval ◽

Logistic Analysis

Abstract Background Carbon monoxide causes electrical, functional, and morphological changes in the heart. It is not clear, however, whether the indices of myocardial damage can predict the patient’s prognosis after carbon monoxide poisoning. This retrospective study aimed to investigate the relation between the carboxyhemoglobin level and electrocardiographic (ECG) changes and whether the ECG changes and troponin I levels are related to the patient’s prognosis after carbon monoxide poisoning. Results Carboxyhemoglobin, troponin I, and ECG parameters were measured in 70 patients with carbon monoxide poisoning. The QT and RR intervals were measured for each ECG lead in all patients, and the corrected QT interval and corrected QT dispersion were calculated. The correlation between the maximum corrected QT interval and the carboxyhemoglobin level was significant (P = 0.0072, R2 = 0.1017), as were the relationships between QT dispersion and carboxyhemoglobin (P < 0.001, R2 = 0.2358) and the corrected QT dispersion and carboxyhemoglobin (P < 0.001, R2 = 0.2613). The multivariate logistic analysis showed that the significant predictors of sequential disability were hyperbaric oxygen therapy (P = 0.0182), corrected QT dispersion (P = 0.0062), and troponin I level (P = 0.0002). Conclusions Patients’ prognosis following carbon monoxide poisoning can be predicted based on corrected QT dispersion and the troponin I level. Patients with myocardial damage should be monitored not only for their cardiovascular outcome but also for their neurological outcome and their prognosis.

Download Full-text

Electrocardiographic Changes Associated With Ibrutinib Exposure

Cancer Control ◽

10.1177/1073274820931808 ◽

2020 ◽

Vol 27 (1) ◽

pp. 107327482093180

Author(s):

Michael G. Fradley ◽

Allan Welter-Frost ◽

Matthew Gliksman ◽

Josephine Emole ◽

Federico Viganego ◽

...

Keyword(s):

Qt Interval ◽

Ventricular Arrhythmias ◽

Qt Dispersion ◽

Corrected Qt Interval ◽

Qt Intervals ◽

Electrocardiographic Changes ◽

The Absolute ◽

Significant Change ◽

Electrocardiographic Parameters ◽

Electrocardiogram Ecg

Although ibrutinib-associated atrial and ventricular arrhythmias have been well described, there is little information about ibrutinib’s effects on other electrocardiographic parameters, particularly the QT interval. Using our database of 137 patients treated with ibrutinib, we retrospectively identified 21 patients in whom an electrocardiogram (ECG) was obtained both prior to and after ibrutinib exposure. All traditional ECG parameters as well as QT dispersion were manually measured by an electrophysiologist. Compared to baseline ECGs, post ibrutinib ECGs demonstrated QT interval shortening from 386 ms to 356 ms ( P = .007), corrected QT interval shortening using Bazett’s formula from 446 ms to 437 ms ( P = .04), and corrected QT interval shortening using Fridericia’s formula from 425 ms to 407 ms ( P = .003). QT dispersion also increased post ibrutinib exposure compared to baseline (39.8 ms vs 57.3 ms, P = .002). There was no significant change in other ECG parameters. In conclusion, both the absolute and corrected QT intervals significantly shortened after ibrutinib exposure, while there was a significant increase in QT dispersion. These findings may point to a common underlying electrophysiologic mechanism of ibrutinib-associated arrhythmias.

Download Full-text

The Relationship between Thyroid Hormone Levels and Corrected QT Interval and QT Dispersion in Non-Diabetic Hemodialysis Patients

Open Journal of Nephrology ◽

10.4236/ojneph.2014.41003 ◽

2014 ◽

Vol 04 (01) ◽

pp. 13-19

Author(s):

Heo-Yeong Kim ◽

Ji Soo Kim ◽

Seung Eun Suh ◽

Yu Kyung Hyun ◽

Kyeong Mi Park ◽

...

Keyword(s):

Thyroid Hormone ◽

Qt Interval ◽

Qt Dispersion ◽

Hemodialysis Patients ◽

Hormone Levels ◽

Corrected Qt Interval ◽

Thyroid Hormone Levels ◽

The Relationship

Download Full-text

QT DISPERSION AND CORRECTED QT INTERVAL IN CHILDREN WITH CHRONIC RENAL FAILURE

Advances in Electrocardiology 2004 ◽

10.1142/9789812702234_0200 ◽

2005 ◽

Author(s):

WALDEMAR BOBKOWSKI ◽

AGNIESZKA NOWAK ◽

JACEK ZACHWIEJA ◽

BARTLOMIEJ MROZINSKI ◽

ALDONA SIWINSKA

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Qt Interval ◽

Qt Dispersion ◽

Corrected Qt Interval

Download Full-text

Effects of atomoxetine on cardiovascular functions and on QT dispersion in children with attention deficit hyperactivity disorder

Cardiology in the Young ◽

10.1017/s1047951111001211 ◽

2011 ◽

Vol 22 (2) ◽

pp. 158-161 ◽

Cited By ~ 9

Author(s):

Ahmet Sert ◽

Cem Gokcen ◽

Ebru Aypar ◽

Dursun Odabas

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Attention Deficit Hyperactivity Disorder ◽

Diastolic Blood Pressure ◽

Attention Deficit ◽

Qt Interval ◽

Qt Dispersion ◽

Corrected Qt Interval ◽

Hyperactivity Disorder ◽

Cardiovascular Functions

AbstractBackgroundAtomoxetine is a central norepinephrine reuptake inhibitor used to treat attention deficit/hyperactivity disorder. The effects of atomoxetine on cardiovascular functions and QT dispersion in children with attention deficit/hyperactivity disorder have not been previously reported. The aim of this study was to analyse cardiovascular functions and QT dispersion on the surface electrocardiogram of children with attention deficit/hyperactivity disorder during atomoxetine therapy.MethodsA total of 40 children – with a mean age of 8.6 plus or minus 2.3 years and a median age of 11 years; ranged from 8 to 14 years – with attention deficit/hyperactivity disorder – with six girls and 34 boys – were included in the study. We recorded the mean systolic and diastolic blood pressure, heart rate, corrected QT interval, QT dispersion, and left ventricular systolic functions at baseline and 5 weeks after atomoxetine therapy.ResultsAtomoxetine decreased baseline mean systolic and diastolic blood pressure; baseline mean heart rate decreased; and baseline mean corrected QT interval and QT dispersion mildly increased. Atomoxetine decreased baseline mean ejection fraction and baseline mean shortening fraction.ConclusionThe results of our study suggest that atomoxetine does not cause clinically significant alterations in QT dispersion, systolic and diastolic blood pressure, heart rate, corrected QT interval, and left ventricular systolic functions during short-term treatment in children with attention deficit/hyperactivity disorder.

Download Full-text