scholarly journals Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study

RMD Open ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e000978 ◽  
Author(s):  
Anna Ilar ◽  
Lars Klareskog ◽  
Saedis Saevarsdottir ◽  
Pernilla Wiebert ◽  
Johan Askling ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Asbestos Exposure ◽  
Population Based ◽  
Case Control ◽  
Swedish Population ◽  
Increased Risk ◽  
Control Study ◽  
Male Workers

ObjectiveAirborne agents including cigarette smoke associate with an increased risk of rheumatoid arthritis (RA). We analysed to which extent occupational exposure to asbestos and silica confers an increased risk of developing serologically defined subsets of RA.MethodsThis Swedish population-based case-control study enrolled incident RA cases between 1996 and 2013 (n=11 285), identified through national public authority and quality registers, as well as from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) Study. Controls (n=1 15 249) were randomly selected from Sweden’s population register and matched on sex, age, index year and county. Occupational histories were obtained from national censuses. Exposure to asbestos and silica was assessed by job-exposure matrices. Logistic regression was used to calculate ORs adjusted for age, sex, county, index year, alcohol use and smoking.ResultsResults showed that male workers exposed to asbestos had higher risk of seropositive RA (OR=1.2, 95% CI 1.0 to 1.4) and seronegative RA (OR=1.2, 95% CI 1.0 to 1.5) compared with unexposed workers. The risk was highest among workers exposed to asbestos from 1970, before a national ban was introduced. Male workers exposed to silica also had higher risk of RA (seropositive RA: OR=1.4, 95% CI 1.2 to 1.6; seronegative RA: OR=1.3, 95% CI 1.0 to 1.5). For the largest subset, seropositive RA, the OR increased with the number of years exposed to silica, up to OR=2.3 (95% CI 1.4 to 3.8, p for trend <0.0001). Women overall had lower ORs than men, but the duration and intensity of their exposure were lower.ConclusionsIn conclusion, we observed an association between asbestos exposure and risk of developing RA and extended previous findings of an association between silica exposure and RA risk, where a dose-response relationship was observed.

scholarly journals Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study

2015 ◽  
Vol 75 (6) ◽  
pp. 997-1002 ◽  
Author(s):  
Chun Lai Too ◽  
Nor Asiah Muhamad ◽  
Anna Ilar ◽  
Leonid Padyukov ◽  
Lars Alfredsson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Dust Exposure ◽  
Environment Interaction ◽  
Malaysian Population ◽  
Increased Risk ◽  
Control Study

ObjectivesLung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). We investigated the association between textile dust exposure and the risk of RA in the Malaysian population, with a focus on women who rarely smoke.MethodsData from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis population-based case–control study involving 910 female early RA cases and 910 female age-matched controls were analysed. Self-reported information on ever/never occupationally exposed to textile dust was used to estimate the risk of developing anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. Interaction between textile dust and the human leucocyte antigen DR β-1 (HLA-DRB1) shared epitope (SE) was evaluated by calculating the attributable proportion due to interaction (AP), with 95% CI.ResultsOccupational exposure to textile dust was significantly associated with an increased risk of developing RA in the Malaysian female population (OR 2.8, 95% CI 1.6 to 5.2). The association between occupational exposure to textile dust and risk of RA was uniformly observed for the ACPA-positive RA (OR 2.5, 95% CI 1.3 to 4.8) and ACPA-negative RA (OR 3.5, 95% CI 1.7 to 7.0) subsets, respectively. We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2).ConclusionsThis is the first study demonstrating that textile dust exposure is associated with an increased risk for RA. In addition, a gene–environment interaction between HLA-DRB1 SE and textile dust exposure provides a high risk for ACPA-positive RA.

scholarly journals Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155956 ◽  
Author(s):  
Kaja Eriksson ◽  
Lena Nise ◽  
Anna Kats ◽  
Elin Luttropp ◽  
Anca Irinel Catrina ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Established Rheumatoid Arthritis ◽  
Swedish Population ◽  
Control Study

scholarly journals Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case–control study

2018 ◽  
Vol 33 (4) ◽  
pp. 415-423 ◽  
Author(s):  
Anna Karin Hedström ◽  
Leszek Stawiarz ◽  
Lars Klareskog ◽  
Lars Alfredsson
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Swedish Population ◽  
Control Study

Increased risk of acute pancreatitis among tetracycline users in a Swedish population-based case–control study

Gut ◽  
2011 ◽  
Vol 61 (6) ◽  
pp. 873-876 ◽  
Author(s):  
Rickard Ljung ◽  
Jesper Lagergren ◽  
Tomas S Bexelius ◽  
Fredrik Mattsson ◽  
Mats Lindblad
Keyword(s):  
Acute Pancreatitis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Swedish Population ◽  
Increased Risk ◽  
Control Study

scholarly journals Occupational exposure to organic dusts and risk of developing rheumatoid arthritis: findings from a Swedish population-based case–control study

RMD Open ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e001049 ◽  
Author(s):  
Anna Ilar ◽  
Per Gustavsson ◽  
Pernilla Wiebert ◽  
Lars Alfredsson
Keyword(s):  
Rheumatoid Arthritis ◽  
Census Data ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Population Based ◽  
Case Control ◽  
Increased Risk ◽  
Flour Dust ◽  
Incident Cases ◽  
Control Study

ObjectivesWe estimated the association between occupational exposures to five different organic dusts: wood, animal, paper, textile and flour dust and the risk of developing rheumatoid arthritis (RA).MethodsThis population-based case–control study analysed 12 582 incident cases and 129 335 controls. Participants were identified from national public authority and quality registers. Census data on occupations were collected 1960–2010 and we estimated the exposure to organic dust with the help of job-exposure matrices. We used logistic regression to assess the OR of seropositive or seronegative RA. Estimates were adjusted for the matching variables (sex, county, age and index year), education and occupational silica exposure.ResultsExposure to animal dust was associated with an increased risk of RA among both men and women. The OR was 1.2 (95% CI=1.1 to 1.4) for seropositive RA and 1.3 (95% CI=1.1 to 1.5) for seronegative RA among ever exposed participants compared with unexposed. The risk increased with duration of exposure for seropositive RA, and participants who had been exposed in five or more censuses had an OR of 1.6 (95% CI=1.1 to 2.2, p for trend=0.003). Exposure to textile dust also generated a significant dose–response relationship for seropositive RA (p for trend=0.014). We detected no association between exposure to wood, paper or flour dust and risk of RA.ConclusionsOverall, exposure to animal dust and textile dust was associated with an increased risk of developing RA. These observations give further support to the notion that airborne exposures are involved in the aetiology of RA.

scholarly journals Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries

2017 ◽  
Vol 75 (3) ◽  
pp. 191-198 ◽  
Author(s):  
Andrea Farioli ◽  
Kurt Straif ◽  
Giovanni Brandi ◽  
Stefania Curti ◽  
Kristina Kjaerheim ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Asbestos Exposure ◽  
Personal Characteristics ◽  
Clinical History ◽  
Population Based ◽  
Case Control ◽  
Cumulative Exposure ◽  
Control Study

ObjectivesTo assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC).MethodsWe conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ml × years) was assessed by applying the NOCCA job-exposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work.ResultsWe observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC.ConclusionsOur study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed.

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