Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries

ObjectivesTo assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC).MethodsWe conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ml × years) was assessed by applying the NOCCA job-exposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work.ResultsWe observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC.ConclusionsOur study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed.

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Association of Mesothelioma Deaths With Cumulated Neighborhood Exposures Due to a Large-Scale Asbestos Cement Plant in Amagasaki City, Japan: A Nested Case-control Study

10.21203/rs.3.rs-574038/v1 ◽

2021 ◽

Author(s):

Yuri Kitamura ◽

Ling Zha ◽

Rong Liu ◽

Masayuki Shima ◽

Tomoki Nakaya ◽

...

Keyword(s):

Occupational Exposure ◽

Large Scale ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Asbestos Exposure ◽

Case Control ◽

Asbestos Cement ◽

Nested Case Control ◽

Dose Dependent ◽

Control Study

Abstract BackgroundAlthough a causal relationship between mesothelioma and asbestos exposure is well known, few studies have shown a relationship to non-occupational exposure, including neighborhood exposure, most likely because of the large effect size of occupational exposure. The aim of this study was to quantify the risk of malignant mesothelioma death associated with neighborhood asbestos exposure due to a large-scale asbestos-cement (AC) plant in Amagasaki, Japan, by properly adjusting for occupational exposure. MethodsThis was a nested case-control study in which a fixed population of 143,929 residents who had been living in Amagasaki City between 1975 and 2002 were followed from 2002 to 2015. All 133 cases and 403 matched controls were interviewed about their occupational, domestic, household, and neighborhood asbestos exposures. Odds ratios (ORs) for mesothelioma death associated with neighborhood exposure were estimated by a conditional logistic-regression model that adjusted for other asbestos exposures. We adopted cumulative indices that considered residence-specific asbestos (crocidolite) concentrations and durations during the potential exposure period of 1957-1975 to evaluate individual neighborhood exposures.ResultsThere was an increasing, dose-dependent risk of mesothelioma death associated with neighborhood exposure, demonstrated by ORs in the highest quintile category that were 21.4 (95%CI: 5.8 to 79.2) for all, 23.7 (95% CI: 3.8-147.2) for males and 26.0 (95% CI: 2.8-237.5) for females, compared to the lowest quintile, respectively. These results clearly demonstrated no substantial differences between males and females in relation to the magnitude of risk from neighborhood exposure.Our findings suggest that the risk of mesothelioma death associated with neighborhood exposure persists and will not be diminished for many years, even though it has been decades since the AC plant closed. ConclusionsBy adjusting for occupational and other asbestos exposures, a dose-dependent relationship was demonstrated between mesothelioma death and neighborhood asbestos exposure from a large-scale AC plant.

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Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study

RMD Open ◽

10.1136/rmdopen-2019-000978 ◽

2019 ◽

Vol 5 (2) ◽

pp. e000978 ◽

Cited By ~ 8

Author(s):

Anna Ilar ◽

Lars Klareskog ◽

Saedis Saevarsdottir ◽

Pernilla Wiebert ◽

Johan Askling ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Occupational Exposure ◽

Case Control Study ◽

Asbestos Exposure ◽

Population Based ◽

Case Control ◽

Swedish Population ◽

Increased Risk ◽

Control Study ◽

Male Workers

ObjectiveAirborne agents including cigarette smoke associate with an increased risk of rheumatoid arthritis (RA). We analysed to which extent occupational exposure to asbestos and silica confers an increased risk of developing serologically defined subsets of RA.MethodsThis Swedish population-based case-control study enrolled incident RA cases between 1996 and 2013 (n=11 285), identified through national public authority and quality registers, as well as from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) Study. Controls (n=1 15 249) were randomly selected from Sweden’s population register and matched on sex, age, index year and county. Occupational histories were obtained from national censuses. Exposure to asbestos and silica was assessed by job-exposure matrices. Logistic regression was used to calculate ORs adjusted for age, sex, county, index year, alcohol use and smoking.ResultsResults showed that male workers exposed to asbestos had higher risk of seropositive RA (OR=1.2, 95% CI 1.0 to 1.4) and seronegative RA (OR=1.2, 95% CI 1.0 to 1.5) compared with unexposed workers. The risk was highest among workers exposed to asbestos from 1970, before a national ban was introduced. Male workers exposed to silica also had higher risk of RA (seropositive RA: OR=1.4, 95% CI 1.2 to 1.6; seronegative RA: OR=1.3, 95% CI 1.0 to 1.5). For the largest subset, seropositive RA, the OR increased with the number of years exposed to silica, up to OR=2.3 (95% CI 1.4 to 3.8, p for trend <0.0001). Women overall had lower ORs than men, but the duration and intensity of their exposure were lower.ConclusionsIn conclusion, we observed an association between asbestos exposure and risk of developing RA and extended previous findings of an association between silica exposure and RA risk, where a dose-response relationship was observed.

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The joint effect of asbestos exposure, tobacco smoking and alcohol drinking on laryngeal cancer risk: evidence from the French population-based case–control study, ICARE

Occupational and Environmental Medicine ◽

10.1136/oemed-2015-102954 ◽

2015 ◽

Vol 73 (1) ◽

pp. 28-33 ◽

Cited By ~ 12

Author(s):

Gwenn Menvielle ◽

Aurore Fayossé ◽

Loredana Radoï ◽

Florence Guida ◽

Marie Sanchez ◽

...

Keyword(s):

Cancer Risk ◽

Tobacco Smoking ◽

Alcohol Drinking ◽

Case Control Study ◽

Asbestos Exposure ◽

Joint Effect ◽

Population Based ◽

Case Control ◽

French Population ◽

Control Study

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717. Antibiotic treatment of Shiga toxin-producing Escherichia coli related gastroenteritis and the risk of hemolytic uremic syndrome: a population based matched case-control study in Japan

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.909 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S409-S410

Author(s):

Shota Myojin ◽

Kyongsun Pak ◽

Mayumi Sako ◽

Tohru Kobayashi ◽

Takuri Takahashi ◽

...

Keyword(s):

Escherichia Coli ◽

Shiga Toxin ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Population Based ◽

Case Control ◽

Age Group ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

Abstract Background The role of therapeutic intervention, particularly antibiotics, for Shiga toxin-producing Escherichia coli (STEC) related infection is controversial. Methods We performed a population based matched case-control study to assess the association between treatment (antibiotics, antidiarrheal agents and probiotics) for STEC related infections and HUS development. We identified all STEC HUS patients as cases and matched five non-HUS patients as controls using the data from the National Epidemiological Surveillance of Infectious Diseases (NESID) between January 1, 2017, and December 31, 2018. Further medical information was obtained by standardized questionnaires answered by physicians who registered each patient. We used multivariate conditional logistic regression model to evaluate the association between exposures (use of antibiotics, use of antidiarrheal agents, days between disease onset and fosfomycin administration [within two or three days]) and the development of HUS, by matched odds ratios (OR) and 95% confidence intervals (CI). Covariates we used were sex, age group, area code, presence of diarrhea and other factors. We also performed subgroup analyses using age (adults and children) as a stratification factor. Results 7,760 STEC related patients were registered in the NESID. We selected patients who had a record of HUS diagnosis (n=182) and matched controls without HUS (n=910). After collecting standardized paper-based questionnaires, we enrolled 90 HUS patients and 371 non-HUS patients for analysis. In the main analysis, matched OR of fosfomycin was 0.75(0.47-1.20) in all ages, 1.41(0.51-3.88) in adults and 0.58(0.34-1.01) in children. Matched OR of antidiarrheal agents was 2.07(1.07-4.03) in all ages, 1.84(0.32-10.53) in adults, 2.65(1.21-5.82) in children. Matched OR of probiotics was 0.86(0.46-1.61) in all ages, 0.76(0.21-2.71) in adults, 1.00(0.48-2.09) in children. There was no significant association between the timing of fosfomycin use in the first two or five days of illness and HUS development in any age group. Conclusion Our results suggest that fosfomycin might decrease the risk of HUS in children younger than 15 years of age with STEC confirmed bacterial gastroenteritis. Disclosures All Authors: No reported disclosures

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Assessment of occupational exposure in a population based case-control study: comparing postal questionnaires with personal interviews.

Occupational and Environmental Medicine ◽

10.1136/oem.54.1.54 ◽

1997 ◽

Vol 54 (1) ◽

pp. 54-59 ◽

Cited By ~ 13

Author(s):

B M Blatter ◽

N Roeleveld ◽

G A Zielhuis ◽

A L Verbeek

Keyword(s):

Occupational Exposure ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Control Study

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Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis: A Population-Based Case-Control Study

Urologia Internationalis ◽

10.1159/000431185 ◽

2015 ◽

Vol 95 (2) ◽

pp. 227-232 ◽

Cited By ~ 7

Author(s):

C.Y. Huang ◽

S.D. Chung ◽

L.T. Kao ◽

H.C. Lin ◽

L.H. Wang

Keyword(s):

Case Control Study ◽

Conditional Logistic Regression ◽

Pain Syndrome ◽

Population Based ◽

Case Control ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

Epithelial Dysfunction ◽

Control Study ◽

Statin Use

Introduction: Statin may induce epithelial dysfunction of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study. Subjects and Methods: This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls. Results: A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for diabetes, hypertension, coronary heart disease, obesity, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma. Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls. Conclusion: We concluded that there was an association between statin use and BPS/IC.

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Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories

Occupational and Environmental Medicine ◽

10.1136/oemed-2017-104666 ◽

2018 ◽

Vol 75 (5) ◽

pp. 328-336 ◽

Cited By ~ 5

Author(s):

Régis Colin ◽

Michel Grzebyk ◽

Pascal Wild ◽

Guy Hédelin ◽

Ève Bourgkard

Keyword(s):

Bladder Cancer ◽

Occupational Exposure ◽

Case Control Study ◽

Occupational Exposures ◽

Case Control ◽

Metalworking Fluids ◽

Cumulative Exposure ◽

Cancer Case ◽

Increased Risk ◽

Control Study

ObjectivesTo assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence.MethodsA nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident bladder cancer case diagnosed from 2006 to 2012. Controls were matched to cases on age at diagnosis and counter-matched on a surrogate measure of exposure to MWFs derived from a job-exposure matrix. Cases (n=84) and controls (n=251) were face-to-face interviewed. Experts assessed occupational exposure to MWFs (straight, soluble and synthetic) using questionnaires and reports from factory visits. Occupational exposures were based on three metrics: duration, frequency-weighted duration and cumulative exposure index. Conditional multiple logistic regressions were used to determine ORs and 95% CIs, taking non-occupational and occupational exposure into account.ResultsIn the 25 years before diagnosis, ORs increased significantly with duration of exposure to straight MWFs (OR=1.13 (1.02–1.25)) and increased with frequency-weighted duration of exposure to straight MWFs (OR=1.44 (0.97–2.14)). These results remained valid after adjusting for duration of smoking, average number of cigarettes smoked per day, time since smoking cessation and exposure to polycyclic aromatic hydrocarbons (PAHs). ORs also increased with soluble MWFs but not significantly. No significant association was found with older exposures to MWFs or with exposure to synthetic MWFs.ConclusionThe increased risk of bladder cancer observed among workers exposed to straight MWFs and to a lesser extent to soluble MWFs may be explained by the presence of carcinogens (such as PAH) in mineral oils component of straight and soluble oils. Prevention therefore remains necessary in sectors using MWFs.

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Association of Consecutive Influenza Vaccinations and Pneumonia: A Population-Based Case-Control Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16061078 ◽

2019 ◽

Vol 16 (6) ◽

pp. 1078

Author(s):

Liang-Tsai Yeh ◽

Chi-Ho Chan ◽

Shun-Fa Yang ◽

Han-Wei Yeh ◽

Ying-Tung Yeh ◽

...

Keyword(s):

Influenza Vaccination ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Population Based ◽

Case Control ◽

Research Database ◽

Conditional Logistic Regression Analysis ◽

Using Data ◽

Influenza Vaccinations ◽

Control Study

The purpose of this study was to investigate whether individuals receiving influenza vaccines have a lower risk of pneumonia. A nationwide population-based case-control study was conducted using data from the National Health Insurance Research Database in Taiwan. We enrolled 7565 patients each in pneumonia and non-pneumonia groups after diagnosis of patients with chronic pulmonary disease, and these patients were individually age and sex matched in a 1:1 ratio. Using conditional logistic regression analysis, adjusted odds ratios (aORs) were estimated in patients who received influenza vaccination and those who had not previously had pneumonia. Moreover, we also analyzed the interval between vaccination and the onset of pneumonia and the number of vaccinations received by patients. This was compared with patients who never received influenza vaccination. Patients who had received influenza vaccination and had been vaccinated for two consecutive years (aOR = 0.85, confidence interval (CI) = 0.79–0.93 and aOR = 0.75, CI = 0.67–0.85, respectively) showed lower rates of pneumonia occurrence by 15–25%. In conclusion, influenza vaccination significantly reduces the occurrence of pneumonia, especially in individuals who receive vaccination in consecutive years.

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