Discriminatory attitudes towards people living with HIV/AIDS and associated factors: a population based study in the Chinese general population

Abstract Background: Globally 38 million people were living with HIV in 2019. In Africa, 25 million people are living with HIV/AIDS undernutrition and food insecurity is endemic. Hence the study aimed to assess the magnitude of undernutrition and associated factors among HIV-infected adults receiving ART. Methods: Institutional based cross-sectional study was conducted among HIV/AIDS patients who following the ART service was selected by a simple random sampling method. The data were collected by direct interview, using a structured questionnaire. Descriptive statistics and a Logistic regression model were employed. Result: The study revealed that the magnitude of under-nutrition was 18.8%. The history of opportunistic infection (AOR=4.518:95% CI: 2.304-8.857), Patients taking ART for less than one year (AOR=3.675:95% CI: 1.831-7.377) household food insecure (AOR= 3.113:95% CI: 1.628-5.950) and dietary diversity score (AOR=2.340:95% CI: 1.221-4.485) were found to have a statistically significant association with undernutrition. Conclusion: The magnitude of undernutrition among people living with HIV/AIDS was found to be high. Having an opportunistic infection, duration of taking ART treatment, household food security status, and dietary diversity status were found to statistically significant association with undernutrition.

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Tuberculosis co-infection and its associated factors among People living with HIV/AIDS attending antiretroviral therapy clinic in southern Ethiopia: a facility based retrospective study

BMC Research Notes ◽

10.1186/s13104-018-3530-3 ◽

2018 ◽

Vol 11 (1) ◽

Cited By ~ 5

Author(s):

Abel Negussie ◽

Damene Debalke ◽

Teshome Belachew ◽

Fetlework Tadesse

Keyword(s):

Retrospective Study ◽

Antiretroviral Therapy ◽

Associated Factors ◽

Southern Ethiopia ◽

People Living With Hiv ◽

Living With Hiv ◽

Therapy Clinic ◽

Hiv Aids

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Polypharmacy and Drug–Drug Interactions in People Living With Human Immunodeficiency Virus in the Region of Madrid, Spain: A Population-Based Study

Clinical Infectious Diseases ◽

10.1093/cid/ciz811 ◽

2019 ◽

Vol 71 (2) ◽

pp. 353-362 ◽

Cited By ~ 7

Author(s):

Beatriz López-Centeno ◽

Carlos Badenes-Olmedo ◽

Ángel Mataix-Sanjuan ◽

Katie McAllister ◽

José M Bellón ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Drug Interactions ◽

Age Groups ◽

Population Based ◽

People Living With Hiv ◽

Traffic Light ◽

Population Based Study ◽

Immunodeficiency Virus ◽

Red Flag ◽

Living With Hiv

Abstract Background Drug–drug interactions (DDIs) that involve antiretrovirals (ARVs) tend to cause harm if unrecognized, especially in the context of comorbidity and polypharmacy. Methods A linkage was established between the drug dispensing registry of Madrid and the Liverpool human immunodeficiency virus (HIV) DDI database (January 2017–June 2017). Polypharmacy was defined as the use of ≥5 non-HIV medications, and DDIs were classified by a traffic-light ranking for severity. Results A total of 22 945 people living with HIV (PLWH) and 6 613 506 individuals without HIV had received medications. ARV regimens were predominantly based on integrase inhibitors (51.96%). Polypharmacy was higher in PLWH (32.94%) than individuals without HIV (22.16%; P < .001); this difference was consistently observed across all age strata except for individuals ≥75 years. Polypharmacy was more common in women than men in both PLWH and individuals without HIV. The prevalence of contraindicated combinations involving ARVs was 3.18%. Comedications containing corticosteroids, quetiapine, or antithrombotic agents were associated with the highest risk for red-flag DDI, and the use of raltegravir- or dolutegravir-based antiretroviral therapy was associated with an adjusted odds ratio of 0.72 (95% confidence interval, .60–.88; P = .001) for red-flag DDI. Conclusions Polypharmacy was more frequent among PLWH across all age groups except those aged ≥75 years and was more common in women. The detection of contraindicated medications in PLWH suggests a likely disconnect between hospital and community prescriptions. Switching to alternative unboosted integrase regimens should be considered for patients with risk of harm from DDIs.

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