S56 Neural respiratory drive and cardiac function in patients with obesity-hypoventilation-syndrome following setup of non-invasive ventilation for hypercapnic respiratory failure

Patients hospitalized with chronic hypercapnic respiratory failure often have comorbidities and are at increased risk for mortality after discharge. Non-invasive ventilation (NIV) has become a common therapy for these patients to improve gas exchange both while hospitalized and after discharge. To understand the survival of hypercapnic respiratory failure patients started on home NIV therapy, a prospective study was conducted analyzing rate of survival and predictors of mortality. Patients had a significant one-year mortality rate of 16.7% ± 0.71%. Analysis of demographic and physiologic data revealed that the only significant predictor of mortality was hours of NIV use per day, with greater use associated with increased mortality. Although initial results indicate that NIV can be an effective long term therapy for chronic hypercapnic respiratory failure, these patients remain at high risk of mortality and require regular monitoring. Continued study will increase this cohort and follow it for longer periods of time to better understand the predictors of mortality in patients hospitalized with chronic hypercapnic respiratory failure. Key words: Obesity hypoventilation syndrome, noninvasive ventilation, hypercapnic respiratory failure

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Hypercapnia Response in Patients With Obesity-Hypoventilation Syndrome Treated With Non-Invasive Ventilation at Home

Archivos de Bronconeumología (English Edition) ◽

10.1016/j.arbr.2018.07.009 ◽

2018 ◽

Vol 54 (9) ◽

pp. 455-459 ◽

Cited By ~ 1

Author(s):

Ramón Fernández Álvarez ◽

Gemma Rubinos Cuadrado ◽

Ines Ruiz Alvarez ◽

Tamara Hermida Valverde ◽

Marta Iscar Urrutia ◽

...

Keyword(s):

Invasive Ventilation ◽

Obesity Hypoventilation Syndrome ◽

Non Invasive ◽

Non Invasive Ventilation ◽

Hypoventilation Syndrome ◽

Obesity Hypoventilation ◽

At Home

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Evaluation of non-invasive ventilation compliance in obstructive sleep apnea syndrome or obesity hypoventilation syndrome patients: an observational study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20205025 ◽

2020 ◽

Vol 8 (12) ◽

pp. 4292

Author(s):

Rajat Agarwal ◽

Rishi Kumar Saini ◽

Aseem Rajpal ◽

Rajesh Agrawal ◽

Amit Kumar

Keyword(s):

Sleep Apnea Syndrome ◽

Invasive Ventilation ◽

Obesity Hypoventilation Syndrome ◽

Sleep Study ◽

Non Invasive ◽

Non Invasive Ventilation ◽

Obstructive Sleep ◽

Apnea Syndrome ◽

Hypoventilation Syndrome ◽

Obesity Hypoventilation

Background: Recent times have seen the rise in obstructive sleep apnea syndrome/obesity hypoventilation syndrome (OSAS/OHS) patients across the globe. Availability of sleep study centers, questionnaires, and more awareness have made the diagnosis of OSAS/OHS early. But still, the majority of patients suffer from morbidity associated with OSAS/OHS despite the better diagnosis, the most common cause being non-adherence to (CPAP). This needs to be addressed more vigilantly and with utmost importance for successful management of OSAS/OHS.Methods: This is an observational study, we selected patients by reviewing sleep study records at a tertiary care center (Rohilkhand medical college and hospital) in Bareilly, India. All diagnosed patients with OSAS/OHS (i.e. AHI >5) were telephoned and enquired about symptoms and non-invasive ventilation (NIV) use. They were evaluated using a self-designed questionnaire.Results: In our study, we had total of 49 OSAS/OHS patients with mean age of 50.6 years and mean BMI of 35.63. Male patients were 37 (75.5%) and at the time of diagnosis AHI (mean) was 60.67 events/hour. In NIV users there were 24 patients (48.97%), 22 patients (91.7%) feel they have been benefitted from CPAP and 2 patients (8.3%) do not feel benefit from CPAP (NIV) use. Among NIV users there was significant drop of AHI (mean) to 8.07. Among NIV users there was a reduction in symptoms like excessive day time sleepiness in 18 patients (81.81%), witnessed apnea in 15 patients (88.23%), snoring in 21 patients (91.30%), blood pressure in 3 patients (21.42%), blood sugar levels in 2 patients (20%), morning headache in 5 patients (83.30%), depressive mood in 2 patients (40%), perceived memory loss in 3 patients (33.3%), sense of choking in 17 patients (94.4%) and weight loss in 19 patients (76%).Conclusions: CPAP significantly improves symptoms and provides objective as well as subjective benefit to OSAS/OHS patients but still significant proportion of patients hesitate to initiate the therapy. Poor education/awareness regarding OSAS/OHS and non-availability of affordable CPAP remains the leading cause of non-compliance. There is a need for early education, reinforcement and affordable CPAP therapy.

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