EFFECT OF INSULIN ON ETHANOL METABOLISM

1954 ◽  
Vol 32 (4) ◽  
pp. 465-469 ◽  
Author(s):  
E. J. Masoro ◽  
Henry Abramovitch
Keyword(s):  
Carbon Dioxide ◽  
Alcohol Intoxication ◽  
Ethanol Metabolism ◽  
P Value ◽  
Acute Alcohol Intoxication ◽  
Beneficial Effects ◽  
Liver Slices

The role of insulin in ethanol metabolism was investigated with the aid of C14-labeled ethanol. Surviving kidney and liver slices prepared from insulized rats oxidized ethanol to carbon dioxide at approximately the same rate as slices prepared from control rats. The data on the effect of insulin on the conversion of ethanol to lipids are equivocal since the P value is 0.036. There appears to be some increase in lipogenesis but not of an appreciable magnitude. The possibility that the beneficial effects noted in the treatment of acute alcohol intoxication with insulin may be the result of an increased synthetic metabolism is discussed.

EFFECT OF INSULIN ON ETHANOL METABOLISM

1954 ◽  
Vol 32 (1) ◽  
pp. 465-469 ◽  
Author(s):  
E. J. Masoro ◽  
Henry Abramovitch
Keyword(s):  
Carbon Dioxide ◽  
Alcohol Intoxication ◽  
Ethanol Metabolism ◽  
P Value ◽  
Acute Alcohol Intoxication ◽  
Beneficial Effects ◽  
Liver Slices

The role of insulin in ethanol metabolism was investigated with the aid of C14-labeled ethanol. Surviving kidney and liver slices prepared from insulized rats oxidized ethanol to carbon dioxide at approximately the same rate as slices prepared from control rats. The data on the effect of insulin on the conversion of ethanol to lipids are equivocal since the P value is 0.036. There appears to be some increase in lipogenesis but not of an appreciable magnitude. The possibility that the beneficial effects noted in the treatment of acute alcohol intoxication with insulin may be the result of an increased synthetic metabolism is discussed.

Role of Plasma Vasopressin in Changes of Water Balance Accompanying Acute Alcohol Intoxication

1995 ◽  
Vol 19 (3) ◽  
pp. 759-762 ◽  
Author(s):  
Hanna Taivainen ◽  
Kalevi Laitinen ◽  
Riitta Tahtela ◽  
Kalervo Kiianmaa ◽  
Matti J. Valimaki
Keyword(s):  
Water Balance ◽  
Alcohol Intoxication ◽  
Acute Alcohol Intoxication ◽  
Plasma Vasopressin

Acute alcohol intoxication among adolescents—the role of the context of drinking

2016 ◽  
Vol 176 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Bettina Grüne ◽  
Daniela Piontek ◽  
Oliver Pogarell ◽  
Armin Grübl ◽  
Cornelius Groß ◽  
...  
Keyword(s):  
Alcohol Intoxication ◽  
Acute Alcohol Intoxication

Investigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxication

2012 ◽  
Vol 31 (3) ◽  
pp. 208-213 ◽  
Author(s):  
Kazim Kartkaya ◽  
Ayşegül Oğlakçı ◽  
Hakan Şentürk ◽  
Gökhan Bayramoğlu ◽  
Mediha Canbek ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Alcohol Intoxication ◽  
Protective Role ◽  
Acute Alcohol Intoxication

scholarly journals Studies of intermediary metabolism in germinating pea cotyledons. The pathway of ethanol metabolism and the role of the tricarboxylic acid cycle

1967 ◽  
Vol 105 (1) ◽  
pp. 323-331 ◽  
Author(s):  
D. S. Cameron ◽  
E. A. Cossins
Keyword(s):  
Carbon Dioxide ◽  
Tricarboxylic Acid Cycle ◽  
Tricarboxylic Acid ◽  
Ethanol Metabolism ◽  
Similar Data ◽  
Tissue Slices ◽  
Acid Cycle ◽  
Pea Seedlings ◽  
Fixation Of Carbon Dioxide

1. The pathway of ethanol metabolism in cotyledons of 3-day-old pea seedlings has been examined by incubating tissue slices with [1−14C]ethanol and [2−14C]ethanol for periods up to 1hr. 2. Ethanol was rapidly incorporated into citrate and glutamate but relatively small amounts of 14C were present in the evolved carbon dioxide even after 1hr. of ethanol metabolism. 3. Similar data were obtained from experiments in which [1,2−14C2]acetaldehyde and [14C]acetate were supplied. 4. The results are interpreted as indicating that ethanol is metabolized essentially via the reactions of the tricarboxylic acid cycle with a substantial drain of α-oxoglutarate to support the biosynthesis of glutamate. 5. It is concluded that oxaloacetate, required for the incorporation of ethanol into citrate, arises mainly from the transamination of aspartate and the fixation of carbon dioxide.

scholarly journals The Protective Effects of Buzui on Acute Alcoholism in Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Chen Chen ◽  
Da-Chao Wen ◽  
Shu-di Gao ◽  
Xiao-yu Hu ◽  
Cheng Yi
Keyword(s):  
Alcohol Intoxication ◽  
Survival Curve ◽  
Blood Alcohol ◽  
Protective Effects ◽  
Acute Alcohol Intoxication ◽  
Final Treatment ◽  
Righting Reflex ◽  
Acute Alcoholism ◽  
Fructus Schisandrae Chinensis

This study was designed to investigate the role of a traditional buzui recipe in anti-inebriation treatment. Buzui consists of Fructus Schisandrae Chinensis, Fructus Chebulae, Fructus Mume, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, and Excrementum Bombycis. The buzui mixture was delivered by gavage, and ethanol was delivered subsequent to the final treatment. The effects of buzui on the righting reflex, inebriation rates, and the survival curve are depicted. Blood alcohol concentrations, alanine aminotransferase (ALT) levels, aspartate aminotransferase (AST) levels, and alkaline phosphatase (ALP) levels were recorded. The activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and superoxide dismutase (SOD), as well as malonaldehyde (MDA) levels, were also measured. Our results demonstrated that a traditional buzui recipe showed significant effects on promoting wakefulness and the prevention of acute alcohol intoxication, accelerating the metabolism of alcohol in the liver and reducing the oxidative damage caused by acute alcoholism.

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