One-pot, solvent-free synthesis of α-aminonitriles under catalysis by magnesium bromide ethyl etherate

2006 ◽  
Vol 84 (3) ◽  
pp. 429-432 ◽  
Author(s):  
Mohammad M Mojtahedi ◽  
M Saeed Abaee ◽  
Hassan Abbasi
Keyword(s):  
Room Temperature ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Magnesium Bromide ◽  
One Pot ◽  
Trimethylsilyl Cyanide ◽  
Mild Conditions ◽  
Rapid Formation ◽  
Solvent Free Synthesis

A three-component, efficient, and facile procedure has been developed for the synthesis of α-aminonitriles from aldehydes, amines, and trimethylsilyl cyanide using a catalytic amount of magnesium bromide ethyl etherate in the absence of solvent. Rapid formation of products is observed at room temperature in a one-pot procedure under very mild conditions giving excellent yields of the title compounds.Key words: catalyzed Strecker's reaction, α-aminonitriles, magnesium bromide, solvent-free.

One-Pot, Solvent-Free Synthesis of α-Aminonitriles under Catalysis by Magnesium Bromide Ethyl Etherate.

ChemInform ◽  
2006 ◽  
Vol 37 (43) ◽  
Author(s):  
Mohammad M. Mojtahedi ◽  
M. Saeed Abaee ◽  
Hassan Abbasi
Keyword(s):  
Solvent Free ◽  
Magnesium Bromide ◽  
One Pot ◽  
Solvent Free Synthesis

Metal- and Solvent-free Synthesis of Functionalized Dihydrooxa­zolo[3,2-a]indoles by One-Pot Tandem Assembly of 3H-Indoles and Propargylic Alcohols

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1445-1454 ◽  
Author(s):  
Boris Trofimov ◽  
Ludmila Oparina ◽  
Nikita Kolyvanov ◽  
Igor Ushakov ◽  
Anastasiya Mal’kina ◽  
...  
Keyword(s):  
Double Bond ◽  
Solvent Free ◽  
One Pot ◽  
Propargylic Alcohols ◽  
Mild Conditions ◽  
Solvent Free Synthesis

The reaction of 3H-indoles with tertiary propargylic alcohols to give functionalized dihydrooxazolo[3,2-a]indoles in good to excellent yields has been developed. This metal- and solvent-free, one-pot tandem assembly proceeds under mild conditions (22–60 °C) and is regio- and stereoselective: either the Z- or E-isomers (relative to the double bond) are alternatively formed depending on other functionalized substituents on the propargylic alcohols.

Solvent-free Synthesis of 1,2-Disubstituted Derivatives of 1,2- Dihydroisoquinoline, 1,2-Dihydroquinoline and 1,2-Dihydropyridine

2013 ◽  
Vol 68 (7) ◽  
pp. 818-822 ◽  
Author(s):  
Rahimeh Hajinasiri ◽  
Sobhan Rezayati
Keyword(s):  
Room Temperature ◽  
Solvent Free ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Approach ◽  
Dialkyl Acetylenedicarboxylates ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
Derivatives Of ◽  
Solvent Free Synthesis

A one-pot and efficient approach to the synthesis of dialkyl 2-[1-[(alkoxycarbonyl)anilino]-2(1H)- (isoquinolin-2-yl) (or -quinolin-1-yl or -pyridin-1-yl)]-2-butenedioates is described. This method involves a three-component reaction between isoquinoline, quinoline or pyridine, dialkyl acetylenedicarboxylates and N-phenylcarbamates under solvent-free conditions, without using any catalyst and at room temperature. The mild reaction conditions and good yields of the products exhibit the synthetic advantage of this method.

scholarly journals Mechanically induced solvent-free esterification method at room temperature

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5080-5085
Author(s):  
Lei Zheng ◽  
Chen Sun ◽  
Wenhao Xu ◽  
Alexandr V. Dushkin ◽  
Nikolay Polyakov ◽  
...  
Keyword(s):  
Natural Products ◽  
Carboxylic Acids ◽  
Late Stage ◽  
Reaction Mechanisms ◽  
Room Temperature ◽  
Solvent Free ◽  
Mild Conditions

We have developed I2/KH2PO2 and KI/P(OEt)3 strategy syntheses of esters from carboxylic acids and alcohols through different reaction mechanisms. The advantages of present protocol: mild conditions and late-stage diversification of natural products.

Room Temperature Solvent-Free Synthesis of Monodisperse Magnetite Nanocrystals

2006 ◽  
Vol 6 (3) ◽  
pp. 852-856 ◽  
Author(s):  
X. R. Ye ◽  
C. Daraio ◽  
C. Wang ◽  
J. B. Talbot ◽  
S. Jin
Keyword(s):  
Oleic Acid ◽  
Solid State ◽  
Large Scale ◽  
Room Temperature ◽  
Solvent Free ◽  
Two Dimensional ◽  
New Process ◽  
High Boiling Point ◽  
Magnetite Nanocrystals ◽  
Solvent Free Synthesis

We have successfully demonstrated a facile, solvent-free synthesis of highly crystalline and monodisperse Fe3O4 nanocrystallites at ambient temperature avoiding any heating. Solid state reaction of inorganic Fe(II) and Fe(III) salts with NaOH was found to produce highly crystalline Fe3O4 nanoparticles. The reaction, if carried out in the presence of surfactant such as oleic acid–oleylamine adduct, generated monodisperse Fe3O4 nanocrystals extractable directly from the reaction mixture. The extracted nanoparticles were capable of forming self-assembled, two-dimensional and uniform periodic array. The new process utilizes inexpensive and nontoxic starting materials, and does not require a use of high boiling point and toxic solvents, thus is amenable to an environmentally desirable, large-scale synthesis of nanocrystals.

ChemInform Abstract: Solvent-Free Synthesis of 2H-Pyrans: One-Pot Reactions of Dithiocarbamates, Alkyl Propiolates, and Isocyanides.

ChemInform ◽  
2012 ◽  
Vol 43 (35) ◽  
pp. no-no
Author(s):  
Zinatossadat Hossaini ◽  
Faramarz Rostami-Charatib ◽  
Rahimeh Hajinasiria ◽  
Hojatollah Jafaryanc ◽  
Mehdi Shahrakid
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Solvent Free Synthesis ◽  
Alkyl Propiolates

Solvent-free synthesis of pyrrolo [2,1-α]isoquinolines via one-pot four-component reaction

2021 ◽  
Vol 18 ◽  
Author(s):  
Ali Aminkhani ◽  
Sina Sharifi
Keyword(s):  
Cycloaddition Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

: An efficient four-component reaction to synthesize pyrrolo[2,1-a]isoquinolines from malononitrile, aromatic aldehydes, isoquinoline, and cyclohexyl isocyanide under solvent-free conditions is described. In a convenient, simple, and efficient one-pot procedure, the domino Knoevenagel-nucleophilic cycloaddition reaction affords excellent yields of products in less than 1 h.

A one-pot, three-component and solvent-free synthesis of 2,3-disubstituted isoindolin-1-ones

2015 ◽  
Vol 56 (33) ◽  
pp. 4729-4732 ◽  
Author(s):  
Mehdi Adib ◽  
Fariba Peytam ◽  
Mohsen Zainali ◽  
Long-Guan Zhu ◽  
Jing Wu
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Solvent Free Synthesis

scholarly journals One Pot Solvent-Free Synthesis of Benzodiazepinones Catalyzed by CuI

2017 ◽  
Vol 37 (4) ◽  
pp. 954
Author(s):  
Qingyang Zhang ◽  
Xiaojian Wang ◽  
Qiong Xiao ◽  
Dali Yin
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Solvent Free Synthesis
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