Deshielding γ–gauche effects in 13C magnetic resonance: a comparison of the conformational behaviour of the acetyl group in cyclohexane and 5-substituted-1,3-dioxane systems
Keyword(s):
Low temperature (173 K) 13C spectra of acetylcyclohexane, 1-acetyl-1-methylcyclohexane, and 5-acetyl-5-methyl-1,3-dioxane are reported. Data permit the first direct measurement of −ΔG0 for the acetyl group bonded to cyclohexane. The value obtained, 1.02 ± 0.05 kcal/mol in CS2–CD2Cl2 solution, is considerably lower than that determined by equilibration methods. Factors contributing to observed axial–equatorial carbonyl carbon chemical shift differences for substituted cyclohexanes and 1,3-dioxanes are discussed.
1995 ◽
Vol 117
(32)
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pp. 8441-8446
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1995 ◽
Vol 99
(43)
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pp. 15806-15813
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1998 ◽
Vol 33
(2)
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pp. 167-176
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2008 ◽
Vol 67
(14)
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pp. 1239-1245
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1983 ◽
Vol 258
(18)
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pp. 10824-10826
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1967 ◽
Vol 89
(25)
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pp. 6784-6785
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1996 ◽
pp. 1455
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