Stability constants and spectral studies of complexes of 2-hydroxy-5-methylazobenzene-2′-carboxylic acid with some divalent metal ions

1984 ◽  
Vol 62 (11) ◽  
pp. 2299-2301
Author(s):  
C. Mahalingam ◽  
J. K. Sthapak ◽  
D. D. Sharma ◽  
R. L. Tiwari ◽  
Smita Sthapak
Keyword(s):  
Carboxylic Acid ◽  
Metal Ions ◽  
Metal Complexes ◽  
Stability Constants ◽  
Divalent Metal ◽  
Reflectance Spectra ◽  
Spectral Studies ◽  
Divalent Metal Ions ◽  
The Stability

The stability constants of metal complexes of 2-hydroxy-5-methylazobenzene-2′-carboxylic acid have been determined spectrophotometrically. These follow the Irving–Williams sequence: log KOH(H) = 10.67, log K1(Co) = 9.02, log K1(Ni) = 9.68, log K1(Cu) = 13.37, log K1(Zn) = 7.58, and [Formula: see text]The chelates of Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), and [Formula: see text] with the dye have been prepared and characterized on the basis of their ir and reflectance spectra.

Metal Complexes of 6-Hydroxymethylpyridine-2-carboxylic Acid

1962 ◽  
Vol 15 (4) ◽  
pp. 786 ◽  
Author(s):  
RW Green ◽  
GKS Ooi
Keyword(s):  
Carboxylic Acid ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Stability Constants ◽  
Steric Hindrance ◽  
Transition Metal Ions ◽  
Complexing Agent ◽  
Ph Titration ◽  
The Stability

Spectrophotometric and pH-titration methods have been used to determine the stability constants at 25 �C of complexes between transition metal ions and the anion of 6-hydroxymethylpyridine-2-carboxylic acid. This anion is found to be a weaker base and a weaker complexing agent than the pyridine-2-carboxylate ion. There is some evidence for steric hindrance of tris complexes.

scholarly journals Structural and Binding Analysis of Pyrimidinol Carboxylic Acid andN-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

2011 ◽  
Vol 55 (6) ◽  
pp. 2905-2915 ◽  
Author(s):  
Eric B. Lansdon ◽  
Qi Liu ◽  
Stephanie A. Leavitt ◽  
Mini Balakrishnan ◽  
Jason K. Perry ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Metal Ions ◽  
Active Site ◽  
Water Environment ◽  
Divalent Metal ◽  
Rnase H ◽  
Accurate Assessment ◽  
Divalent Metal Ions ◽  
Substrate State ◽  
Hiv 1

ABSTRACTHIV-1 RNase H breaks down the intermediate RNA-DNA hybrids during reverse transcription, requiring two divalent metal ions for activity. Pyrimidinol carboxylic acid andN-hydroxy quinazolinedione inhibitors were designed to coordinate the two metal ions in the active site of RNase H. High-resolution (1.4 Å to 2.1 Å) crystal structures were determined with the isolated RNase H domain and reverse transcriptase (RT), which permit accurate assessment of the metal and water environment at the active site. The geometry of the metal coordination suggests that the inhibitors mimic a substrate state prior to phosphodiester catalysis. Surface plasmon resonance studies confirm metal-dependent binding to RNase H and demonstrate that the inhibitors do not bind at the polymerase active site of RT. Additional evaluation of the RNase H site reveals an open protein surface with few additional interactions to optimize active-site inhibitors.

scholarly journals Effect of Divalent Metal Ions on the Stability of Cu-Containing Layered Double Hydroxides

2012 ◽  
Vol 28 (07) ◽  
pp. 1714-1720 ◽  
Author(s):  
NI Zhe-Ming ◽  
◽  
LIU Jiao ◽  
XUE Ji-Long ◽  
LI Yuan ◽  
...  
Keyword(s):  
Metal Ions ◽  
Layered Double Hydroxides ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
The Stability ◽  
Double Hydroxides

Studies on the solvent extraction of metal dithiocarbamates

1969 ◽  
Vol 47 (12) ◽  
pp. 2320-2323 ◽  
Author(s):  
Vedula S. Sastri ◽  
Keijo I. Aspila ◽  
Chuni L. Chakrabarti
Keyword(s):  
Solvent Extraction ◽  
Stability Constants ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Extraction Constants ◽  
Overall Stability ◽  
Stability Constants Of Complexes ◽  
Dithiocarbamic Acid ◽  
The Stability ◽  
Metal Dithiocarbamates

Studies on the solvent extraction of morpholine dithiocarbamic acid complexes of divalent metal ions Mn, Fe, Co, Ni, Cu, Zn, Pb, Cd, Hg, and Sn were carried out, and the extraction constants and the overall stability constants were determined. The stability constants of complexes of Cu(II) formed with various substituted dithiocarbamic acids, showed a variation of the stability constants with the basicity of the nitrogen and sulfur atoms in the reagents.

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