cis-Cyclohexano-9-crown-3 ether. Solid state and low-temperature solution stereochemistry as determined by X-ray crystallography and nuclear magnetic resonance spectroscopy

1993 ◽  
Vol 71 (7) ◽  
pp. 951-959 ◽  
Author(s):  
G.W. Buchanan ◽  
A.B. Driega ◽  
A. Moghimi ◽  
C. Bensimon ◽  
K. Bourque
Keyword(s):  
Low Temperature ◽  
Nmr Spectra ◽  
Solid Phase ◽  
Resonance Spectroscopy ◽  
Ring Inversion ◽  
X Ray ◽  
Common Features ◽  
X Ray Crystallography ◽  
Temperature Solution ◽  
C Nmr

The X-ray crystal structure of the title material has been determined at −130 °C. Low-temperature 1H1H COSY, 13C1H HETCOR, and DEPT 13C NMR spectra have been recorded, which permit unambiguous assignments of all carbon resonances when ring inversion is slow on the NMR timescale. The limiting low-temperature solution phase 13C spectrum has many common features with the solid phase 13C CPMAS spectrum recorded at 300 K. Spectra for the 7,10-tetra-deuterio derivative have also been obtained and substituent influences on 13C shieldings are discussed in detail.

Stereochemistry of crown ethers, X-ray crystallographic structures, solid phase 13C NMR, and solution conformational equilibria in cis-syn-cis dicyclohexano-15-crown-5 ether and its sodium thiocyanate complex

1992 ◽  
Vol 70 (3) ◽  
pp. 981-991 ◽  
Author(s):  
G W Buchanan ◽  
S. Mathias ◽  
C. Bensimon ◽  
J. P. Charland
Keyword(s):  
Crown Ethers ◽  
Solid Phase ◽  
Sodium Thiocyanate ◽  
Free Energies ◽  
Ring Inversion ◽  
Thiocyanate Complex ◽  
X Ray ◽  
X Ray Crystallography ◽  
Temperature Solution ◽  
In Cis

The structures of the title materials have been determined via X-ray crystallography. In the free crown ether, there is effectively a plane of symmetry that bisects the molecule. In the NaNCS complex, ring inversion of one of the cyclo-hexane moieties has occurred, giving a distorted pentagonal pyramidal coordination geometry about the sodium ion. For the free crown, two conformers, whose free energies differ by ca. 0.5 kJ / mol in solution can be detected via 13C NMR at 168 K. Limiting low-temperature solution spectra are compared to those which have been obtained in the solid phase using the 13C CPMAS technique. Key words: crown ethers, stereochemistry, X-ray, NMR.

The relative stabilities of PhE(NH-t-Bu)2 and PhE(μ-N-t-Bu)2EPh (E = As, Sb, and Bi): X-ray structures of {Li2[PhAs(N-t-Bu)2]}2 and PhE(μ-N-t-Bu)2EPh (E = Sb, Bi)

2003 ◽  
Vol 81 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Glen G Briand ◽  
Tristram Chivers ◽  
Masood Parvez
Keyword(s):  
Solid State ◽  
Nmr Spectra ◽  
Phenyl Group ◽  
Synthetic Approach ◽  
Relative Stabilities ◽  
X Ray ◽  
X Ray Crystallography ◽  
In Trans ◽  
C Nmr

The reaction of PhECl2 with 2 equiv of LiHN-t-Bu has been studied for the series E = As, Sb, and Bi to determine the effect of the phenyl group on subsequent amine condensation processes. For PhAsCl2, the metathesis product PhAs(NH-t-Bu)2 4 was obtained as a colourless oil. Similar reactions involving PhECl2, where E = Sb or Bi, yielded the cyclodipnict(III)azanes PhE(μ-N-t-Bu)2EPh 5 (E = Sb) and 6 (E = Bi), respectively. Treatment of 4 with 2 equiv of n-BuLi produced the dilithium salt Li2[PhAs(N-t-Bu)2] 7a. Products 4, 5, 6, and 7a were characterized by 1H, 7Li (7a), and 13C NMR spectra, while 5, 6, and 7a were also structurally characterized by X-ray crystallography. Compound 7a is dimeric in the solid state via intermolecular Li···N and η6-Li···Ph interactions. The cyclodipnict(III)azanes 5 and 6 have similar structures, with the exocyclic phenyl groups in trans positions relative to the E2N2 ring. This synthetic approach provides a new route to the four-membered rings RE(μ-N-t-Bu)2ER (E = Sb, Bi) and the first example of a bis(organyl)cyclodibism(III)azane.Key words: arsenic, antimony, bismuth, amides, imides.

On the chemistry and high field nuclear magnetic resonance spectroscopy of rapamycin

1980 ◽  
Vol 58 (6) ◽  
pp. 579-590 ◽  
Author(s):  
John A. Findlay ◽  
Lajos Radics
Keyword(s):  
High Field ◽  
Nmr Spectra ◽  
Resonance Spectroscopy ◽  
X Ray ◽  
Conformational Isomers ◽  
H Nmr ◽  
Neutral Compounds ◽  
Complete Assignment ◽  
Hydrolysis Of ◽  
C Nmr

Base catalysed hydrolysis of rapamycin (C51H79NO13) affords six neutral compounds identified by chemical and spectroscopic means as 2a, 3b, 3d, 5, 2,4-dimethylphenol, and L(−)-piperidine-2-carboxylic acid 6, and whose generation has been plausibly rationalized. These findings as well as detailed analyses of 13C nmr and 1H nmr spectra provide independent corroboration of the X-ray derived rapamycin crystal structure 1. Structurally homogeneous in the solid state, rapamycin is found to occur in solutions as a mixture of two conformational isomers (approximately 4:1). Through nearly complete assignment of the high field 1H (400 MHz) and 13C (100.6 MHz) nmr spectra, the isomerism is shown to be associated with trans–cis rotation of an amidic bond within the 31-membered macrolide ring. The predominant form corresponds to the conformer portrayed by X-ray analysis.

Triferrocenylborane – Molecular Structure in Solution and in the Solid State

1995 ◽  
Vol 50 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Bernd Wrackmeyer ◽  
Udo Dörfler ◽  
Wolfgang Milius ◽  
Max Herberhold
Keyword(s):  
Molecular Structure ◽  
Solid State ◽  
Low Temperature ◽  
Single Crystal ◽  
Nmr Spectra ◽  
The Other ◽  
X Ray ◽  
Single Diastereomer ◽  
Structure In Solution ◽  
C Nmr

According to a single crystal X-ray structure determination all three ferrocenyl substituents of triferrocenylborane (1) adopt the same orientation with respect to the BC3-plane [P21/c monoclinic; Z = 4; a = 1353.5(3), b = 1695.6(3), c = 1056.4(2) pm, β = 109.27(3)°]. The simulated X-ray powder pattern of the single crystal is identical with the powder diagram of a macroscopic sample, indicating the presence of a single diastereomer (1a) in the solid state. However, at low temperature (< - 95 °C) in solution, the 13C NMR spectra suggest the presence of the second diastereomer (1b) in which one ferrocenyl group is oriented opposite to the other two with respect to the central BC3-plane.

Structural studies on 6-ethoxytetrahydropyrylium cations; stereoelectronic control in the reactions of lactonium salts

1991 ◽  
Vol 69 (12) ◽  
pp. 2024-2032 ◽  
Author(s):  
Ronald F. Childs ◽  
Marianne D. Kostyk ◽  
Colin J. L. Lock ◽  
Mailivaganam Mahendran
Keyword(s):  
Nmr Spectra ◽  
Positive Charge ◽  
Nucleophilic Attack ◽  
Structural Studies ◽  
Narrow Line ◽  
Crystal Lattices ◽  
X Ray ◽  
X Ray Crystallography ◽  
Stereoelectronic Control ◽  
C Nmr

The structures of 6-ethoxy-2,3,4,5-tetrahydropyrylium, 1, 6-ethoxy-2-methyl-2,3,4,5-tetrahydropyrylium, 2, and 2-ethoxy-3,4,4a,5,6,7,8,8a-octahydro-1-benzopyrylium, 3, hexachloroantimonates have been determined by X-ray crystallography. In each case the tetrahydropyrylium rings exist in shallow half-chair conformations with the cationic centers C(6), C(5), O(1), and O(6) having a planar arrangement. The cations all have a Z conformation about the O(6)—C(7) bonds and it is shown that this conformation is also preferred in solution by comparison of narrow-line 13C NMR spectra in the solid state and solution. The O(1)—C(2) and O(6)—C(7) bond distances in 1–3 are significantly longer than those of comparable bonds in neutral esters. The length of the O(1)—C(2) bond is very dependent on substitution at C(2) suggesting a considerable fraction of the positive charge resides on this carbon as well as C(7). The closest cation/anion interactions present in the crystal lattices of these salts are between the chlorine atoms of the anion and the cationic center, C(6). These interactions provide information on the origin of the stereoselectivity observed in nucleophilic attack on these cations. The conformations, details of the C—O bonding, and closest contacts between cation and anion are discussed in terms of the concept of stereoelectronic control. Key words: 6-ethoxytetrahydropyrylium cations, lactonium salts, structure, X-ray, stereoelectronic control.

Solid state and solution stereochemistry of crown ethers and models. ortho-Dimethoxydiphenyl ether and related dibenzo-15-crown-5 and tetrabenzo-30-crown-10 ethers as studied by X-ray crystallography and 1H and 13C NMR spectroscopy

1994 ◽  
Vol 72 (5) ◽  
pp. 1218-1224 ◽  
Author(s):  
G. W. Buchanan ◽  
A. Rodrigue ◽  
K. Bourque ◽  
A. C. Chiverton ◽  
I. R. Castleden ◽  
...  
Keyword(s):  
Solid Phase ◽  
Direct Methods ◽  
13C Nmr Spectroscopy ◽  
Structural Features ◽  
X Ray Diffraction ◽  
1H And 13C Nmr ◽  
Space Group ◽  
X Ray ◽  
X Ray Crystallography ◽  
C Nmr

Solid phase 45.3 MHz 13C NMR spectra of ortho-dimethoxydiphenyl ether, 1, dibenzo[b,e]-15-crown-5- ether, 2, and tetrabenzo[b,e,q,t]-30-crown-10 ether, 3, have been obtained. Chemical shift trends are discussed in terms of the asymmetric units and structural features available from X-ray crystallographic data. Comparison with solution 13C spectra are made. The crystal structures of 1 and 3 were determined by X-ray diffraction at room temperature. 1 crystallizes in space group P21/a with a = 13.366(1), b = 8.230(1), c = 12.303(1) Å, β = 116.63(1)°, Z = 4. 3 crystallizes in space group P21/c with a = 7.903(1), b = 26.337(2), c = 7.852(1) Å, β = 97.28(1)°, Z = 2. The structures were solved by direct methods and refined by full-matrix least squares to residuals of 0.055 using 1727 reflections for 1 and of 0.042 using 2590 reflections for 3.

The photochemical nucleophile–olefin combination, aromatic substitution (photo-NOCAS) reaction. Part 11: Involving (R)-(+)-α-terpineol and (R)-(+)-limonene, substituting on 1,4-dicyanobenzene

1996 ◽  
Vol 74 (4) ◽  
pp. 602-612 ◽  
Author(s):  
Donald R. Arnold ◽  
Dennis A. Connor ◽  
Kimberly A. McManus ◽  
Pradip K. Bakshi ◽  
T. Stanley Cameron
Keyword(s):  
Electron Transfer ◽  
Photoinduced Electron Transfer ◽  
Nmr Spectra ◽  
Radical Cations ◽  
Acetonitrile Solution ◽  
Aromatic Substitution ◽  
X Ray ◽  
X Ray Crystallography ◽  
Intramolecular Reactions ◽  
C Nmr

Irradiation of an acetonitrile–methanol (3:1) solution of 1,4-dicyanobenzene (1), biphenyl (5), and (R)-(+)-limonene (21) leads to formation of the 1:1:1 (methanol:21:1) photo-NOCAS adducts: 4-[(1R,2S,4R)-4-isopropenyl-2-methoxy-1-methylcyclohexyl]benzonitrile (23, 30%), 4-[(1S,2R,4R)-4-isopropenyl-2-methoxy-1-methylcyclohexyl]benzonitrile (24, 2%), 4-[(1R,2R,5R)-5-isopropenyl-2-methoxy-2-methylcyclohexyl]benzonitrile (25, 3%), and 4-[(1S,2S,5R)-5-isopropenyl-2-methoxy-2-methylcyclohexyl]benzonitrile (26, 1%). When an acetonitrile solution (no added methanol) of 1,4-dicyanobenzene (1), biphenyl (5), and (R)-(+)-α-terpineol (22) was irradiated under these conditions, the products were the cyclized 1:1 (22:1) photo-NOCAS adducts: (1R,2S,5R)-2-(4-cyanophenyl)-2,6,6-trimethyl-7-oxabicyclo[3.2.1]octane (27,21%) and (1S,4R,6R)-6-(4-cyanophenyl)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane (28, 2%). Structural assignments were based primarily upon detailed analysis of 1H and 13C nmr spectra and, for four of the products (24, 26, 27, and 28), structures were firmly established by X-ray crystallography. The mechanism for the formation of these products is discussed, with emphasis on the intramolecular reactions of the intermediate alkene radical cations. Molecular mechanics (MM3) calculations gave information regarding the structure and energy of the conformers of 21 and 22 that was useful for predicting/explaining the observed reactivity on the basis of approach vector analysis; the transition state for cyclization incorporates the nucleophile and the alkene radical cation carbon atoms at the vertices of an obtuse triangle orthogonal to the plane of the π-system. Key words: photoinduced electron transfer, radical cations, cyclization, terpenes.

The structure of 2,2-dibutyl-1,3,2-dioxastannane in the solid state and in solution

1992 ◽  
Vol 70 (1) ◽  
pp. 197-204 ◽  
Author(s):  
T. Bruce Grindley ◽  
Rasiah Thangarasa ◽  
Pradip K. Bakshi ◽  
T. Stanley Cameron
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Carbon Atom ◽  
Low Temperature ◽  
Nmr Spectra ◽  
Monomer Unit ◽  
The Other ◽  
Mirror Plane ◽  
X Ray ◽  
X Ray Crystallography

Crystals of 2,2-dibutyl-1,3,2-dioxastannane (1) are orthorhombic, of space group Pnma, with a = 7.663(3), b = 18.437(2), c = 9.277(4) Å, Z = 4, R = 0.0568 (Rw = 0.0551) for 1183 independent reflections with I > 3σ(I). Compound 1 is a polymer in which each monomer unit is joined to the next by a four-membered (SnO)2 ring. The Sn—O bond lengths inside the monomer units average 2.04 Å while those between monomers average 2.57 Å. The mirror plane of the crystal contains the atoms in the four-membered rings and the other oxygen atoms. Two of the three remaining carbon atoms in the six-membered rings of the monomer units are close to the mirror plane. The other carbon atom is disordered above and below the plane. It was shown by 119Sn NMR spectroscopy that solutions of 1 contain mixtures of oligomers that consist mainly of dimers, trimers, and tetramers in chloroform-d. ΔG0 values for dimmer–trimer equilibria and dimmer–tetramer equilibria of −2.5 and −1.5 kcal mol−1 were obtained from integration of low temperature 119Sn NMR spectra. These values favour the higher oligomers slightly less than those for 2,2-dibutyl-1,3,2-dioxastannolane. Keywords: 1,3,2-dioxastannanes, stannylene acetals. X-ray crystallography, 119Sn NMR spectroscopy.

Structure in the solid state and conformational analysis in solution of 1,4-diacetyl-1,4-dihydro-2,3-diphenylpyrazine, a potential antiaromatic heterocyclic compound

1982 ◽  
Vol 60 (3) ◽  
pp. 349-354 ◽  
Author(s):  
Joseph Armand ◽  
Claudette Bois ◽  
Michèle Philoche-Levisalles ◽  
Marie-José Pouet ◽  
Marie-Paule Simonnin
Keyword(s):  
Solid State ◽  
Nitrogen Atom ◽  
Conformational Analysis ◽  
Nmr Spectra ◽  
Equilibrium Mixture ◽  
X Ray ◽  
X Ray Crystallography ◽  
Nitrogen Bonds ◽  
Unambiguous Assignment ◽  
C Nmr

It is shown by X-ray crystallography that the 1,4-dihydropyrazine skeleton of 1,4-diacetyl-1,4-dihydro-2,3-diphenylpyrazine 2 has a boat shape. The C(2)–C(3) and C(5)–C(6) double bonds are localized; therefore 2 does not exist as an azahomoaromatic entity with 6 electrons delocalized on the ring and two electrons localized on one nitrogen atom. In the solid state 2 is in a Z, Z conformation. The 1H and 13C nmr spectra indicate that 2 exists as an equilibrium mixture of Z,E, E,E, and Z,Z conformers in CD2Cl2 at −80 °C. An unambiguous assignment of the different sets of signals has been obtained by nOe experiments performed at −80 °C. The conformer distribution is the following: 65% (Z,E), 22% (E,E), and 13% (Z,Z). The relatively low barrier to rotation about the carbonyl nitrogen bonds of the two amide groups [Formula: see text] is in line with a rather large C—N bond length (~1.375 Å) in the crystal.

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