EFFECTS OF INHIBITORS OF SULFANILAMIDE ACETYLATION ON SULPHONAMIDE BLOOD CONCENTRATIONS
1955 ◽
Vol 33
(1)
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pp. 523-529
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Keyword(s):
The effect of inhibitors of sulphanilamide acetylation on free and total sulphonamide blood levels has been investigated. p-Aminosalicylic acid hydrazide, administered to rabbits in combination with sulphanilamide, produced a twofold increase in the blood level of free sulphanilamide six hours after a single oral dose. Similarly, p-aminosalicylate and p-(dipropylsulphamyl)-benzoic acid together were responsible for a twofold increase in free-sulphonamide blood level six hours after a single oral dose of a triple sulphonamide mixture. Salicylamide and 5-bromosalicylamide were ineffective. The significance of these results is discussed.
1955 ◽
Vol 33
(4)
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pp. 523-529
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Keyword(s):
1986 ◽
Vol 31
(4)
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pp. 299-303
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Keyword(s):
1962 ◽
Vol 13
(2)
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pp. 307
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Keyword(s):
2017 ◽
Vol 1041-1042
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pp. 175-182
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Keyword(s):
1973 ◽
Vol 30
(03)
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pp. 494-498
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Keyword(s):
1970 ◽
Vol 31
(2)
◽
pp. 281-287
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