Vasoactive Actions of Prostaglandins and Serotonin on Isolated Human Umbilical Arteries and Veins

1972 ◽  
Vol 50 (5) ◽  
pp. 393-399 ◽  
Author(s):  
Myung K. Park ◽  
Charles Rishor ◽  
Donald C. Dyer
Keyword(s):  
Propylene Glycol ◽  
High Concentration ◽  
Umbilical Arteries ◽  
Arteries And Veins ◽  
Prostaglandins E

Cumulative responses to prostaglandins E1 (PGE1), E2 (PGE2), F1α(PGF1α), and F2α (PGF2α) were obtained on isolated human umbilical arteries and veins. All four prostaglandins produced contractions. PGF2α was the most active prostaglandin on umbilical arteries, while PGE2 and PGF2α were equiactive and more potent than PGE1 or PGF1α on umbilical veins. 5-Hydroxytryptamine (5-HT) was at least 100 times more potent than the prostaglandins. SC-19220, a prostaglandin antagonist, in a high concentration was found to moderately antagonize the vasoactive effect of PGE2 and to slightly antagonize contractions to 5-HT. Also, propylene glycol, the solvent for SC-19220, was observed to antagonize contractions to both PGE2 and 5-HT, thereby indicating that solvent controls are necessary when evaluating compounds such as SC-19220.

LYCOPENE POWDER PRODUCING FROM GAC FRUIT TOWARDS APPLICATIONS IN NUTRACEUTICAL AND COSMETICS

2016 ◽  
pp. 51-56
Author(s):  
Thi Le Thuy Nguyen ◽  
Thanh Sinh Do ◽  
Thi Hoa Tran
Keyword(s):  
Key Words ◽  
Propylene Glycol ◽  
Mass Production ◽  
Toxic Substances ◽  
High Concentration ◽  
Concentration Determination ◽  
Modified Method ◽  
Β Carotene ◽  
Key Words Carotenoids

Backgroud: Gac is a fruit containing many antioxidants, especially lycopene, with high concentration. However the variety and value of products from gac are limited. We introduce a modified method to produce lycopene and others carotenoids from gac oil towards available and safe applications in nutraceutical and cosmetics. Materials and method: We study the extraction with different parameters and limit at the saponification of gac oil using less toxic substances such as ethanol, propylene glycol, postasium hydroxide and sodium chlorid. Results: Concentrations of lycopene and β-carotene determined silmutaneously by UVVis spectrophotometer present that the efficiency reaches 65.07% as 20 g of gac oil is saponified with 8 g KOH 12 mol/L in 120 mins. The purity of product is 89.02%. Conclusions: This process could minimize toxic residue in the powder after the precipitation, filtration and washing. Besides, the method is stable and applicable to the mass production. Key words: Carotenoids, Lycopene, safe extraction, UV Vis silmutaneous concentration determination

scholarly journals The Croonian lecture. On the existence of nerves in the placenta

1833 ◽  
Vol 2 ◽  
pp. 226-227
Keyword(s):  
Blood Vessels ◽  
Pregnant Uterus ◽  
Umbilical Arteries ◽  
Arteries And Veins

In this lecture the author makes known his discovery of the ex­istence of nerves, both in the fœtal and maternal portions of the pla­centa. His previous researches had led him to doubt the existence of blood-vessels without nerves, and the extreme vascularity of the placenta led him to suspect them in that organ. With the assistance of Mr. Bauer, therefore, he first examined the placenta of the Seal, the arteries and veins of which had been injected, and in which nerves were discovered, not only surrounding the umbilical arteries, but also in the uterine portion. In the pregnant uterus of the Tapir of Sumatra, in which, there being no placenta, the umbilical chord is connected with the chorion, the nerves were very conspicuous in the transparent portion of the chorion, along which the branches of the funis pass before they ar­rive at the spongy part.

Etomidate Does Not Alter Recovery after Anoxia of Evoked Population Spikes Recorded from the CA1 Region of Rat Hippocampal Slices 

1998 ◽  
Vol 88 (5) ◽  
pp. 1274-1280 ◽  
Author(s):  
Eduarda M. Amadeu ◽  
Elisabeth A. Abramowicz ◽  
Geoffrey Chambers ◽  
James E. Cottrell ◽  
Ira S. Kass
Keyword(s):  
Propylene Glycol ◽  
Adenosine Triphosphate ◽  
Hippocampal Slices ◽  
Population Spike ◽  
High Concentration ◽  
Population Spikes ◽  
Ca1 Region ◽  
Cardiovascular Depression ◽  
Collateral Pathway

Background Etomidate is an anesthetic agent that reduces the cerebral metabolic rate and causes minimal cardiovascular depression. Its ability to improve recovery after anoxia or ischemia is equivocal. An in vitro neuronal preparation was used to examine the action of etomidate on electrophysiologic and biochemical parameters during and after anoxia. Methods The Schaffer collateral pathway was stimulated, and a postsynaptic evoked population spike was recorded from the CA1 pyramidal cell layer of rat hippocampal slices. Etomidate or propylene glycol, its solvent, was present 15 min before, during, and 10 min after anoxia. Adenosine triphosphate, sodium, and potassium concentrations were measured at the end of anoxia in tissue treated with etomidate, propylene glycol, or with no added drugs. Results Etomidate did not alter recovery after 6 min of anoxia. The population spikes from untreated slices recovered to 32% of their preanoxic amplitude, and slices treated with 0.5, 3, and 30 microg/ml etomidate recovered to 24%, 35%, and 13%, respectively. Slices treated with propylene glycol, equivalent to that in 3 and 30 microg/ml etomidate, recovered to 46% and 12%, respectively, and this was not significantly different from untreated slices. Etomidate did not attenuate the decrease in adenosine triphosphate concentrations during anoxia. The increase in sodium and the decrease in potassium during anoxia were significantly attenuated by 30 but not by 3 microg/ml etomidate. Conclusions A range of etomidate concentrations did not significantly alter recovery of the evoked population spike after anoxia in rat hippocampal slices. A high concentration of etomidate did attenuate the increase in sodium and the decrease in potassium during anoxia.

Fatty acid composition of umbilical arteries and veins: Possible implications for the fetal EFA-status

Lipids ◽  
1989 ◽  
Vol 24 (6) ◽  
pp. 511-517 ◽  
Author(s):  
G. Hornstra ◽  
A. C. van Houwelingen ◽  
M. Simonis ◽  
J. M. Gerrard
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Umbilical Arteries ◽  
Arteries And Veins
Sign in / Sign up

Export Citation Format

Share Document