BRAIN SHIFT ESTIMATION FOR IMAGE GUIDED SURGERY BASED ON AN INTEGRATED RANGE-SENSING, SEGMENTATION AND REGISTRATION FRAMEWORK

This paper presents a review about neurosurgery, robotic assistants in this type of procedure, and the approach to the problem of brain tissue displacement, including techniques for obtaining medical images. It is especially focused on the phenomenon of brain displacement, commonly known as brain shift, which causes a loss of reference between the preoperative images and the volumes to be treated during image-guided surgery. Hypothetically, with brain shift prediction and correction for the neuronavigation system, minimal invasion trajectories could be planned and shortened. This would reduce damage to functional tissues and possibly lower the morbidity and mortality in delicate and demanding medical procedures such as the removal of a brain tumor. This paper also mentions other issues associated with neurosurgery and shows the way robotized systems have helped solve these problems. Finally, it highlights the future perspectives of neurosurgery, a branch of medicine that seeks to treat the ailments of the main organ of the human body from the perspective of many disciplines.

Download Full-text

Evaluation of factors predicting accurate resection of high-grade gliomas by using frameless image-guided stereotactic guidance

Neurosurgical FOCUS ◽

10.3171/foc.2003.14.2.6 ◽

2003 ◽

Vol 14 (2) ◽

pp. 1-4 ◽

Cited By ~ 11

Author(s):

Ronald Benveniste ◽

Isabelle M. Germano

Keyword(s):

Mr Imaging ◽

Extent Of Resection ◽

Image Guided Surgery ◽

High Grade ◽

Brain Shift ◽

Patient Age ◽

Guided Surgery ◽

Image Guided ◽

Patient Âgé ◽

High Grade Gliomas

Object Frameless image-guided stereotaxy is often used in the resection of high-grade gliomas. The authors of several studies, however, have suggested that brain shift may occur intraoperatively and result in inaccurate resection. To determine the usefulness of frameless stereotactic image-guided surgery of high-grade gliomas, the authors correlated factors predictive of brain shift, such as tumor size, periventricular location, and patient age (as an indicator of brain atrophy) with the extent of resection. Methods Inclusion criteria included the following: 1) stereotactic volumetric craniotomy for resection of tumor; 2) histologically proven high-grade glioma; 3) preoperative magnetic resonance (MR) imaging demonstration of an enhancing portion of tumor; 4) postoperative MR imaging within 48 hours to assess the extent of resection; and 5) preoperative intention to perform gross-total resection of the enhancing tumor. Fifty-four patients met these criteria between September 1997 and November 2002. Accurate resection was considered to be indicated by a lack of nodular enhancement on postoperative Gd-enhanced MR images obtained within 48 hours of surgery. Frameless stereotactic image-guided surgery resulted in the successful resection of 46 (85%) of 54 high-grade gliomas. Accurate resection was significantly more likely with tumors less than 30 ml in volume than with those greater than 30 ml (93 and 58%, respectively [p < 0.05]). In addition, small periventricular tumors were associated with significant less successful resection compared with nonperiventricular tumor (77 and 96%, respectively [p = 0.5]). Patient age did not affect the likelihood of successful resection. Conclusions Frameless image-guided stereotactic techniques can be reliably used for accurate resection of high-grade gliomas when the tumor is less than 30 ml in volume and not adjacent to the ventricular system. In cases involving tumors larger in volume or located near the ventricles, intraoperative ultrasonography or MR imaging updates should be considered.

Download Full-text

A CT-ultrasound-coregistered augmented reality enhanced image-guided surgery system and its preliminary study on brain-shift estimation

Journal of Instrumentation ◽

10.1088/1748-0221/7/08/p08016 ◽

2012 ◽

Vol 7 (08) ◽

pp. P08016-P08016 ◽

Cited By ~ 3

Author(s):

C H Huang ◽

C H Hsieh ◽

J D Lee ◽

W C Huang ◽

S T Lee ◽

...

Keyword(s):

Augmented Reality ◽

Image Guided Surgery ◽

Brain Shift ◽

Guided Surgery ◽

Image Guided ◽

Preliminary Study

Download Full-text

An integrated range-sensing, segmentation and registration framework for the characterization of intra-surgical brain deformations in image-guided surgery

Computer Vision and Image Understanding ◽

10.1016/s1077-3142(03)00004-3 ◽

2003 ◽

Vol 89 (2-3) ◽

pp. 226-251 ◽

Cited By ~ 44

Author(s):

Michel A Audette ◽

Kaleem Siddiqi ◽

Frank P Ferrie ◽

Terry M Peters

Keyword(s):

Image Guided Surgery ◽

Range Sensing ◽

Guided Surgery ◽

Image Guided

Download Full-text

Three-Dimensional Localization: From Image-Guided Surgery to Information-Guided Therapy

Methods ◽

10.1006/meth.2001.1234 ◽

2001 ◽

Vol 25 (2) ◽

pp. 186-200 ◽

Cited By ~ 20

Author(s):

Richard D. Bucholz ◽

Kurt R. Smith ◽

Keith A. Laycock ◽

Leslie L. McDurmont

Keyword(s):

Three Dimensional ◽

Image Guided Surgery ◽

Guided Surgery ◽

Image Guided ◽

Guided Therapy

Download Full-text

Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00920-6 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Xiaojing Shi ◽

Caiguang Cao ◽

Zeyu Zhang ◽

Jie Tian ◽

Zhenhua Hu

Keyword(s):

Fluorescent Probes ◽

Signal Intensity ◽

Tumor Imaging ◽

Tumor Resection ◽

Optical Signal ◽

Gadolinium Oxide ◽

Image Guided Surgery ◽

Guided Surgery ◽

Image Guided ◽

The Impact

AbstractCerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it’s interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu3+ doped gadolinium oxide (Gd2O3:Eu) was synthesized and combined with radiopharmaceuticals to achieve a red-shifted optical spectrum with less tissue scattering and enhanced optical signal intensity in this study. The interaction between Gd2O3:Eu and radiopharmaceutical were investigated using 18F-fluorodeoxyglucose (18F-FDG). The ex vivo optical signal intensity of the mixture of Gd2O3:Eu and 18F-FDG reached 369 times as high as that of CLI using 18F-FDG alone. To achieve improved biocompatibility, the Gd2O3:Eu nanoparticles were then modified with polyvinyl alcohol (PVA), and the resulted nanoprobe PVA modified Gd2O3:Eu (Gd2O3:Eu@PVA) was applied in intraoperative tumor imaging. Compared with 18F-FDG alone, intraoperative administration of Gd2O3:Eu@PVA and 18F-FDG combination achieved a much higher tumor-to-normal tissue ratio (TNR, 10.24 ± 2.24 vs. 1.87 ± 0.73, P = 0.0030). The use of Gd2O3:Eu@PVA and 18F-FDG also assisted intraoperative detection of tumors that were omitted by preoperative positron emission tomography (PET) imaging. Further experiment of image-guided surgery demonstrated feasibility of image-guided tumor resection using Gd2O3:Eu@PVA and 18F-FDG. In summary, Gd2O3:Eu can achieve significantly optimized imaging property when combined with 18F-FDG in intraoperative tumor imaging and image-guided tumor resection surgery. It is expected that the development of the Gd2O3:Eu nanoparticle will promote investigation and application of novel nanoparticles that can interact with radiopharmaceuticals for improved imaging properties. This work highlighted the impact of the nanoprobe that can be excited by radiopharmaceuticals emitting CL, β, and γ radiation for precisely imaging of tumor and intraoperatively guide tumor resection.

Download Full-text