THREE-DIMENSIONAL MODEL OF METASTATIC TUMOR ANGIOGENESIS IN RESPONSE TO ANTI-ANGIOGENIC FACTOR ANGIOSTATIN

Surgeons observed that primary tumors are capable of suppressing the growth of their metastases by generating anti-angiogenic factor angiostatin. A three-dimensional (3D) mathematical model of development of the metastatic tumor vasculature is presented to simulate the morphology and construction of 3D microvascular networks under the inhibitory effect of anti-angiogenic factor angiostatin excreted by the primary tumor. The simulation results demonstrate that metastatic tumor microvascular density (MVD) decreases by about 60%, 58% and 52%, respectively, at [Formula: see text], 7 and 14 days under the effect of anti-angiogenic factor angiostatin. The abnormal geometric and morphological features of 3D microvasculature networks inside and outside the metastatic tumor improve in the presence of angiostatin. The present model may allow to simulate experimental tests and may provide theoretical models for clinical research of anti-angiogenic therapy strategies.

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Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis

Reproductive Biology ◽

10.1016/j.repbio.2020.07.012 ◽

2020 ◽

Vol 20 (4) ◽

pp. 484-490

Author(s):

Mohammad Rasool Khazaei ◽

Zahra Rashidi ◽

Farzaneh Chobsaz ◽

Elham Niromand ◽

Mozafar Khazaei

Keyword(s):

Three Dimensional ◽

Inhibitory Effect ◽

Endometrial Tissue ◽

Dimensional Model ◽

Three Dimensional Model

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A Surface Vorticity Analysis of Three-Dimensional Flow through Strongly Swept Turbine Cascades

Journal of Mechanical Engineering Science ◽

10.1243/jmes_jour_1974_016_077_02 ◽

1974 ◽

Vol 16 (6) ◽

pp. 425-433 ◽

Cited By ~ 4

Author(s):

D. Graham ◽

R. I. Lewis

Keyword(s):

Three Dimensional ◽

Experimental Tests ◽

Theoretical Models ◽

Spanwise Direction ◽

Three Dimensional Flow ◽

End Effects ◽

Dimensional Flow ◽

Blade Row ◽

Flow Through ◽

The Subject

The two-dimensional surface vorticity theory of Martensen is extended to deal with the full three-dimensional flow through a swept turbine cascade, including end effects. Basic concepts of surface vorticity theories are dealt with initially, as also are three three-dimensional flow considerations for swept cascades. The paper goes on to develop two theoretical models for the representation of swept blade row flows. The first model assumes that the blade bound vorticity remains constant across the span of the blade. In the second model, this assumption is relaxed so that the blade bound vorticity is allowed to vary in the spanwise direction. In both cases the theories are applied to turbine nozzle cascades. Some of the solutions obtained are compared with experimental tests which were the subject of a previous paper.

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Interaction-induced zero-energy pinning and quantum dot formation in Majorana nanowires

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.9.203 ◽

2018 ◽

Vol 9 ◽

pp. 2171-2180 ◽

Cited By ~ 15

Author(s):

Samuel D Escribano ◽

Alfredo Levy Yeyati ◽

Elsa Prada

Keyword(s):

Quantum Dot ◽

Three Dimensional ◽

Theoretical Models ◽

Wave Functions ◽

Zero Energy ◽

Three Dimensional Model ◽

Semiconducting Nanowires ◽

Non Local ◽

Majorana Modes ◽

Energy Quantum

Majorana modes emerge in non-trivial topological phases at the edges of specific materials such as proximitized semiconducting nanowires under an external magnetic field. Ideally, they are non-local states that are charge-neutral superpositions of electrons and holes. However, in nanowires of realistic length their wave functions overlap and acquire a finite charge that makes them susceptible to interactions, specifically with the image charges that arise in the electrostatic environment. Considering a realistic three-dimensional model of the dielectric surroundings, here we show that, under certain circumstances, these interactions lead to a suppression of the Majorana oscillations predicted by simpler theoretical models, and to the formation of low-energy quantum-dot states that interact with the Majorana modes. Both features are observed in recent experiments on the detection of Majoranas and could thus help to properly characterize them.

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Numerical Analysis of Thermal Behaviour of DC Fuse

Energies ◽

10.3390/en13143736 ◽

2020 ◽

Vol 13 (14) ◽

pp. 3736

Author(s):

Adrian Plesca

Keyword(s):

Thermal Behaviour ◽

Thermal Model ◽

Three Dimensional ◽

Experimental Tests ◽

Three Dimensional Model ◽

Simulation Data ◽

Different Types ◽

Short Circuits ◽

Good Concordance ◽

Electrical Apparatus

One of the very well-known protections for electrical apparatus against overloads or short circuits is the fuse. It can be used to protect both AC or DC electrical installations and it has also proven its effectiveness in the protection of different loads. This paper describes a three-dimensional model of a DC fuse with two different types of fuselink notches: circular and rhombic. The obtained 3D thermal model can be used to investigate the thermal behaviour of DC fuses in both steady-state and transient conditions at different values of overloads or short circuits. With the aim to validate the proposed 3D thermal model, a series of experimental tests have been achieved. The thermal simulated values are in good concordance with the experimental results (a relative error less than ±6% has been obtained between experimental and simulation data).

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Seismic Fragility Assessment of an Isolated Multipylon Cable-Stayed Bridge Using Shaking Table Tests

Advances in Civil Engineering ◽

10.1155/2017/9514086 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Yutao Pang

Keyword(s):

Fragility Curves ◽

Three Dimensional ◽

Experimental Tests ◽

Shaking Table ◽

Seismic Fragility ◽

Shaking Table Tests ◽

Three Dimensional Model ◽

Cable Stayed Bridge ◽

High Flexibility ◽

Cable Stayed Bridges

In recent decades, cable-stayed bridges have been widely built around the world due to the appealing aesthetics and efficient and fast mode of construction. Numerous studies have concluded that the cable-stayed bridges are sensitive to earthquakes because they possess low damping characteristics and high flexibility. Moreover, cable-stayed bridges need to warrant operability especially in the moderate-to-severe earthquakes. The provisions implemented in the seismic codes allow obtaining adequate seismic performance for the cable-stayed bridge components; nevertheless, they do not provide definite yet reliable rules to protect the bridge. To date, very few experimental tests have been carried out on the seismic fragility analysis of cable-stayed bridges which is the basis of performance-based analyses. The present paper is aimed at proposing a method to derive the seismic fragility curves of multipylon cable-stayed bridge through shake table tests. Toward this aim, a 1/20 scale three-dimensional model of a 22.5 m cable-stayed bridge in China is constructed and tested dynamically by using the shaking table facility of Tongji University. The cable-stayed bridge contains three pylons and one side pier. The outcomes of the comprehensive shaking table tests carried out on cable-stayed bridge have been utilized to derive fragility curves based on a systemic approach.

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An Efficient Quasi-Three-Dimensional Model of Tilting Pad Journal Bearing for Turbomachinery Applications

Journal of Vibration and Acoustics ◽

10.1115/1.4031408 ◽

2015 ◽

Vol 137 (6) ◽

Cited By ~ 8

Author(s):

Andrea Rindi ◽

Stefano Rossin ◽

R. Conti ◽

A. Frilli ◽

E. Galardi ◽

...

Keyword(s):

High Speed ◽

Computational Cost ◽

Three Dimensional ◽

Experimental Tests ◽

Journal Bearings ◽

Three Dimensional Model ◽

Accurate Analysis ◽

Technical Data ◽

Plant Behavior ◽

Tilting Pad

The constant increase of turbomachinery rotational speed has brought the design and the use of journal bearings to their very limits: tilting pad journal bearings (TPJBs) have been introduced for high-speed/high-load applications due to their intrinsic stability properties and can be used both in transient and steady-state operations obtaining superior performances. An accurate analysis of the TPJBs behavior is essential for a successful design and operation of the system; however, it is necessary to reach a compromise between the accuracy of the results provided by the TPJB model and its computational cost. This research paper exposes the development of an innovative and efficient quasi-3D TPJB modeling approach that allows the simultaneous analysis of the system rotordynamics and the supply plant behavior; the majority of existing models describe these aspects separately but their complex interaction must be taken into account to obtain a more accurate characterization of the system. Furthermore, the proposed model is characterized by a high numerical efficiency and modularity, allowing for complex transient simulations of the complete plant and for the representation of different kind of bearings. The TPJB model has been developed and experimentally validated in collaboration with an industrial partner which provided the technical data of the system and the results of experimental tests.

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