A delayed reaction–diffusion viral infection model with nonlinear incidences and cell-to-cell transmission

2021 ◽  
Author(s):  
Qing Ge ◽  
Xia Wang ◽  
Libin Rong
Keyword(s):  
Viral Infection ◽  
Traveling Wave Solutions ◽  
Neumann Boundary ◽  
Reaction Diffusion ◽  
Infection Model ◽  
Threshold Dynamics ◽  
Delayed Reaction ◽  
Homogeneous Neumann Boundary Condition ◽  
Cell Transmission ◽  
Viral Infection Model

In this paper, we propose a reaction–diffusion viral infection model with nonlinear incidences, cell-to-cell transmission, and a time delay. We impose the homogeneous Neumann boundary condition. For the case where the domain is bounded, we first study the well-posedness. Then we analyze the local stability of homogeneous steady states. We establish a threshold dynamics which is completely characterized by the basic reproduction number. For the case where the domain is the whole Euclidean space, we consider the existence of traveling wave solutions by using the cross-iteration method and Schauder’s fixed point theorem. Finally, we study how the speed of spread in space affects the spread of cells and viruses. We obtain the existence of the wave speed, which is dependent on the diffusion coefficient.

scholarly journals Threshold Dynamics and Competitive Exclusion in a Virus Infection Model with General Incidence Function and Density-Dependent Diffusion

Complexity ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-20 ◽  
Author(s):  
Xiaosong Tang ◽  
Zhiwei Wang ◽  
Jianping Yang
Keyword(s):  
Viral Infection ◽  
Competitive Exclusion ◽  
Neumann Boundary ◽  
Infection Model ◽  
Threshold Dynamics ◽  
Single Strain ◽  
Density Dependent ◽  
Incidence Function ◽  
Infection Models ◽  
Viral Infection Model

In this paper, we investigate single-strain and multistrain viral infection models with general incidence function and density-dependent diffusion subject to the homogeneous Neumann boundary conditions. For the single-strain viral infection model, by using the linearization method and constructing appropriate Lyapunov functionals, we obtain that the global threshold dynamics of the model is determined by the reproductive numbers for viral infection ℛ0. For the multistrain viral infection model, we have discussed the competitive exclusion problem. If the reproduction number ℛi for strain i is maximal and larger than one, the steady state Ei corresponding to the strain i is globally stable. Thus, competitive exclusion happens and all other strains die out except strain i. Meanwhile, we can prove that the single-strain and multistrain viral infection models are well posed. Furthermore, numerical simulations are also carried out to illustrate the theoretical results, which is seldom seen in the relevant known literatures.

scholarly journals Stability and Hopf Bifurcation in a Three-Component Planktonic Model with Spatial Diffusion and Time Delay

Complexity ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Kejun Zhuang ◽  
Gao Jia ◽  
Dezhi Liu
Keyword(s):  
Hopf Bifurcation ◽  
Equilibrium Solution ◽  
Neumann Boundary ◽  
Reaction Diffusion ◽  
Time Behavior ◽  
Delayed Reaction ◽  
Constant Equilibrium ◽  
Homogeneous Neumann Boundary Condition ◽  
Long Time ◽  
The Stability

Due to the different roles that nontoxic phytoplankton and toxin-producing phytoplankton play in the whole aquatic system, a delayed reaction-diffusion planktonic model under homogeneous Neumann boundary condition is investigated theoretically and numerically. This model describes the interactions between the zooplankton and two kinds of phytoplanktons. The long-time behavior of the model and existence of positive constant equilibrium solution are first discussed. Then, the stability of constant equilibrium solution and occurrence of Hopf bifurcation are detailed and analyzed by using the bifurcation theory. Moreover, the formulas for determining the bifurcation direction and stability of spatially bifurcating solutions are derived. Finally, some numerical simulations are performed to verify the appearance of the spatially homogeneous and nonhomogeneous periodic solutions.

Global Stability and Hopf Bifurcation in a Delayed Viral Infection Model with Cell-to-Cell Transmission and Humoral Immune Response

2019 ◽  
Vol 29 (12) ◽  
pp. 1950161 ◽  
Author(s):  
Jinhu Xu ◽  
Yan Geng ◽  
Suxia Zhang
Keyword(s):  
Immune Response ◽  
Hopf Bifurcation ◽  
Viral Infection ◽  
Humoral Immune Response ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Humoral Immune ◽  
Cell Transmission ◽  
Viral Infection Model ◽  
Intracellular Delays

We have developed a class of viral infection model with cell-to-cell transmission and humoral immune response. The model addresses both immune and intracellular delays. We also constructed Lyapunov functionals to establish the global dynamical properties of the equilibria. Theoretical results indicate that considering only two intracellular delays did not affect the dynamical behavior of the model, but incorporating an immune delay greatly affects the dynamics, i.e. an immune delay may destabilize the immunity-activated equilibrium and lead to Hopf bifurcation, oscillations and stability switches. Our results imply that an immune delay dominates the intracellular delays in the model. We also investigated the direction of the Hopf bifurcation and the stability of the periodic solutions by applying normal form and center manifold theory, and investigated the existence of global Hopf bifurcation by regarding the immune delay as a bifurcation parameter. Numerical simulations are carried out to support the analytical conclusions.

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