A Comparative Study of Periosteal New-Bone Response in Metastatic Bone Tumors (Solitary) and Primary Bone Sarcomas

Objectives: Bone tumors are uncommon. Nevertheless, bone is a common site for metastasis. Due to limited data regarding bone tumors in Jordan, this study aims to understand better bone tumor epidemiology and distribution in the Jordanian population. Methods: A part of a retrospective, single-center study, all biopsy reports confirming the diagnosis of a bone tumor between January 2017 and December 2019 were abstracted from Princess Iman Research Center records. The patients’ age, gender, anatomical location, and histopathological type of the tumors were obtained and analyzed. Results: Two hundred eighty-four diagnostic and excisional biopsies were reviewed. Most of the patients (60.2%) were males. The mean age for the patients was 26.74(±16.29) years. Malignant bone tumors were diagnosed in 15.5%. The femur was the most common site of biopsy diagnosed tumor followed by the tibia. Osteochondroma was the most commonly diagnosed benign tumor and accounted for 39.4%, followed by aneurysmal bone cysts (14.8%), and enchondroma (10.2%). The metastatic bone tumors were the most frequent malignant bone pathology (6.7%), while osteosarcoma was the most common primary sarcoma, diagnosed in 5.6% of the sample. Increasing age, pelvic, and spine location of bone tumors were found to be significantly associated with malignancy. Conclusion: In our 284 samples, osteochondromas were the most commonly diagnosed tumors (39.4%), followed by aneurysmal bone cysts (14.8%), and enchondromas (10.2%). Metastatic tumors were the most common malignant bone pathologies, while osteosarcomas were the most common primary bone sarcomas. Femur and tibia were the most common tumor-located sites. Breast and lung deposition were the most common metastasis primaries. Additionally, increasing age, pelvic, and spine-located bone tumors were significantly associated with malignancy.

Download Full-text

Lymphography in Bone and Soft Tissue Sarcomas. Experiences from Three Institutions

Tumori Journal ◽

10.1177/030089168006600606 ◽

1980 ◽

Vol 66 (6) ◽

pp. 721-728 ◽

Cited By ~ 2

Author(s):

Kaj Tallroth ◽

Francisco Makai ◽

Renato Musumeci

Keyword(s):

Lymph Node ◽

Soft Tissue ◽

Diagnostic Accuracy ◽

Bone Tumors ◽

Soft Tissue Sarcomas ◽

Hematogenous Spread ◽

Primary Bone Tumor ◽

Bone Sarcomas ◽

Neurogenic Sarcoma ◽

Primary Bone

The case material was collected from 3 Institutions with a total of 411 patients: 217 with primary bone tumor and 224 with soft tissue sarcomas. In the majority of patients lymphography was performed during the initial diagnostic workup. The lymphograms were interpreted as negative or positive for metastases. In bone tumors, the incidence of metastases was 21 %, ranging from 28 % for osteosarcoma to 18 % for Ewing's sarcoma and 13 % for chondrosarcoma. In tumors of the soft tissue, the frequency was somewhat higher (28%), with special regard to rhabdomyosarcoma (53%), anaplastic sarcoma (67 %), neurogenic sarcoma (42%) and synovial sarcoma (35%). In the group of bone sarcomas, primary hematogenous spread was 3 times more frequent than lymphogenous spread, while in soft tissue sarcomas, with a higher incidence of lymphatic spread, this finding was inverted. In the more consistent tumor groups, the occurrence of lymphatic metastases indicated a significant worsening of the prognosis. In 96 patients, lymph node biopsies were performed and the radiologic histologic correlation gave evidence of a 91.7 % overall diagnostic accuracy.

Download Full-text

Rare Primary Malignant Bone Sarcomas

Cancers ◽

10.3390/cancers12113092 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3092

Author(s):

Emanuela Palmerini ◽

Alberto Righi ◽

Eric L. Staals

Keyword(s):

Ewing Sarcoma ◽

Bone Tumors ◽

Spindle Cell ◽

Clinical Aspects ◽

Vascular Tumors ◽

Nerve Sheath Tumor ◽

Round Cell ◽

Primary Bone Tumors ◽

Bone Sarcomas ◽

Primary Bone

Rare primary malignant bone sarcomas (RPMBS), other than osteosarcoma, chondrosarcoma, chordoma, and Ewing sarcoma, account for about 5–10% of primary bone tumors and represent a major diagnostic challenge. These tumors include spindle cell and round cell sarcoma entities, hemangiopericytoma-like and vascular tumors. Additionally, several histotypes, traditionally described in the soft tissues, such as myxofibrosarcoma, synovial sarcoma, and malignant peripheral nerve sheath tumor of bone, have been reported in patients with primary bone tumors. While wide surgical resection is the mainstay of local treatment, systemic therapy of these rare entities is controversial. Patients with undifferentiated spindle cell or pleomorphic high-grade tumors of bone, are usually treated with osteosarcoma-like chemotherapy, while patients with round cell and undifferentiated round cell tumors (URCTs), may respond to sarcoma treatment regimens for Ewing sarcoma patients. Studies on analogies and differences among these ultra-rare tumors have seldom been reported. This review describes relevance, clinical aspects, diagnostic procedures, staging, treatment recommendations, and current research in this composite tumor group.

Download Full-text

Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

Nuklearmedizin ◽

10.1055/s-0037-1620567 ◽

1982 ◽

Vol 21 (04) ◽

pp. 136-139 ◽

Cited By ~ 2

Author(s):

C.-J. Edeling

Keyword(s):

Soft Tissue ◽

Bone Scintigraphy ◽

Primary Tumor ◽

Bone Tumors ◽

Whole Body ◽

Skeletal Metastases ◽

Malignant Bone Tumors ◽

67Ga Scintigraphy ◽

Primary Bone Tumors ◽

Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

Download Full-text

Computed tomography analysis of primary bone tumors : the significance in the evaluation of destructive lesionsof pelvic bone

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1988.24.4.648 ◽

1988 ◽

Vol 24 (4) ◽

pp. 648

Author(s):

J S Suh ◽

E J Lee ◽

C Y Park

Keyword(s):

Computed Tomography ◽

Bone Tumors ◽

Pelvic Bone ◽

Primary Bone Tumors ◽

Primary Bone ◽

Tomography Analysis

Download Full-text

CRYOSURGERY IN THE TREATMENT OF PATIENTS WITH BONE TUMORS

Problems in oncology ◽

10.37469/0507-3758-2019-65-2-165-171 ◽

2019 ◽

Vol 65 (2) ◽

pp. 165-171

Author(s):

Aleksey Belyaev ◽

Georgiy Prokhorov ◽

Anna Arkhitskaya

Keyword(s):

Liquid Nitrogen ◽

Bone Tumors ◽

Cryogenic Treatment ◽

Long Term Results ◽

Bone Lesions ◽

Giant Cell Tumors ◽

Primary Bone Tumors ◽

Circulation Circuit ◽

Recent Emergence ◽

Primary Bone

A review of the literature shows that surgical procedures will remain the standard treatment for primary bone tumors. Analysis of studies on the assessment of long-term results shows that additional double cryogenic treatment of the curettage cavity can improve the treatment outcomes of patients with giant cell tumors, dysplastic diseases and some forms of malignant lesions. The traditional execution of the procedure is associated with the open installation of liquid nitrogen in the bone cavity, which requires special skills in handling aggressive refrigerant from the staff and does not exclude complications. In case of multiple metastatic bone lesions, surgical treatment is not indicated. The recent emergence in clinical practice of new equipment with a closed liquid nitrogen circulation circuit inside cryoprobes resumes interest in cryoabla-tion of bone tumor lesions using modern minimally invasive puncture cryotechnology and expanding indications for its use in patients with severe comorbidities.

Download Full-text

Wide Surgery in the Cervical Spine: Indications, Results, and Complications in a Series of 30 Patients Affected by Primary Bone Tumors

World Neurosurgery ◽

10.1016/j.wneu.2021.08.054 ◽

2021 ◽

Author(s):

Alessandro Luzzati ◽

Gennaro Maria Scotto ◽

Luca Cannavò ◽

Giuseppe Orlando ◽

Alessandra Scotto di Uccio ◽

...

Keyword(s):

Cervical Spine ◽

Bone Tumors ◽

Primary Bone Tumors ◽

Primary Bone

Download Full-text

Primary Bone Tumors and Tumorous Conditions in Children. Pathologic and Radiologic Diagnosis

Journal of Clinical Pathology ◽

10.1136/jcp.47.4.383-a ◽

1994 ◽

Vol 47 (4) ◽

pp. 383-383

Author(s):

A. Freemont

Keyword(s):

Bone Tumors ◽

Radiologic Diagnosis ◽

Primary Bone Tumors ◽

Primary Bone

Download Full-text

Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2014-0432-oa ◽

2015 ◽

Vol 139 (9) ◽

pp. 1149-1155 ◽

Cited By ~ 31

Author(s):

Xiaohui Niu ◽

Hairong Xu ◽

Carrie Y. Inwards ◽

Yuan Li ◽

Yi Ding ◽

...

Keyword(s):

Mayo Clinic ◽

Bone Tumors ◽

Age Distribution ◽

Chinese Patients ◽

Malignant Bone Tumors ◽

Primary Bone Tumors ◽

Male Predominance ◽

Primary Bone ◽

Different Populations ◽

Epidemiologic Characteristics

Context Although primary bone tumors are extremely rare, the literature suggests that there are variations in the epidemiologic characteristics in different populations. The most frequently cited epidemiologic characteristics of primary bone tumors are derived from a large US series (Mayo Clinic), with no comparable study thus far performed in China. Objective To identify any potential epidemiologic differences between Chinese patients and a US series of patients. Design We performed a comparison study between 9200 patients treated at Beijing Ji Shui Tan Hospital (JST) and 10 165 patients treated at Mayo Clinic (MC), Rochester Minnesota. Detailed epidemiologic features were analyzed. Results We found that giant cell tumor and osteosarcoma have significantly higher incidences in the JST than the MC patients (P < .001). However, JST patients had a significantly lower incidence of Ewing sarcoma, chordoma, fibrosarcoma, myeloma, and malignant lymphoma (P < .001). For most benign and malignant bone tumors, the Chinese cohort had a more distinct male predominance than the US cohort. Malignant bone tumors had a monomodal age distribution in the JST patient group, with a bimodal age distribution in the MC cohort. Also, there were was a predilection for tumors of the femur and tibia among the JST patients (P < .001). Conclusions Our data confirm that epidemiologic variations of primary bone tumors exist in different populations. Factors that may contribute to these observed differences are proposed and discussed.

Download Full-text