Bone tumors distribution in diagnostic and excisional biopsies

Objectives: Bone tumors are uncommon. Nevertheless, bone is a common site for metastasis. Due to limited data regarding bone tumors in Jordan, this study aims to understand better bone tumor epidemiology and distribution in the Jordanian population. Methods: A part of a retrospective, single-center study, all biopsy reports confirming the diagnosis of a bone tumor between January 2017 and December 2019 were abstracted from Princess Iman Research Center records. The patients’ age, gender, anatomical location, and histopathological type of the tumors were obtained and analyzed. Results: Two hundred eighty-four diagnostic and excisional biopsies were reviewed. Most of the patients (60.2%) were males. The mean age for the patients was 26.74(±16.29) years. Malignant bone tumors were diagnosed in 15.5%. The femur was the most common site of biopsy diagnosed tumor followed by the tibia. Osteochondroma was the most commonly diagnosed benign tumor and accounted for 39.4%, followed by aneurysmal bone cysts (14.8%), and enchondroma (10.2%). The metastatic bone tumors were the most frequent malignant bone pathology (6.7%), while osteosarcoma was the most common primary sarcoma, diagnosed in 5.6% of the sample. Increasing age, pelvic, and spine location of bone tumors were found to be significantly associated with malignancy. Conclusion: In our 284 samples, osteochondromas were the most commonly diagnosed tumors (39.4%), followed by aneurysmal bone cysts (14.8%), and enchondromas (10.2%). Metastatic tumors were the most common malignant bone pathologies, while osteosarcomas were the most common primary bone sarcomas. Femur and tibia were the most common tumor-located sites. Breast and lung deposition were the most common metastasis primaries. Additionally, increasing age, pelvic, and spine-located bone tumors were significantly associated with malignancy.

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Aneurysmal bone cyst arising in iliopubic chondromyxoid fibroma – a case report

Clinical surgery research communications ◽

10.31491/csrc.2021.06.074 ◽

2021 ◽

Vol 5 (2) ◽

pp. 10-14

Author(s):

João Soares do Vale ◽

◽

Sara Diniz ◽

Filipe Rodrigues ◽

◽

...

Keyword(s):

Aneurysmal Bone Cyst ◽

Bone Tumors ◽

Bone Cyst ◽

Bone Cysts ◽

Chondromyxoid Fibroma ◽

Primary Bone Tumors ◽

Rare Association ◽

Cartilaginous Tumor ◽

Aneurysmal Bone Cysts ◽

Primary Bone

Chondromyxoid fibroma is rare cartilaginous tumor, accounting for 0.5% of all primary bone tumors and 2% of benign bone tumors. Areas of aneurysmal bone cysts (ABC) may be found within CMF in 8.6% of cases. A 20-year-old man presents pain due to a mass on iliopubic ramus that was diagnosed as an aneurysmal bone cyst arising from a chondromyxoid fibroma. This case confirms the rare association between aneurysmal bone cyst and chondromyxoid fibroma. Although aneurysmal bone cyst is more frequently associated with highly vascularized tumors, it is important to consider the diagnosis in the presence of chondromyxoid fibroma. Keywords: Chondromyxoid fibroma; scecondary aneurysmal bone cyst; iliopubic ramus

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KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimickers

10.21203/rs.3.rs-29911/v1 ◽

2020 ◽

Author(s):

Lucen Jiang ◽

Jianghuan Liu ◽

Qingzhu Wei ◽

Yiyang Wang

Keyword(s):

Bone Tumor ◽

Bone Tumors ◽

Diagnostic Value ◽

Benign Tumors ◽

Malignant Bone Tumor ◽

Malignant Bone Tumors ◽

Potential Marker ◽

Tumors Of Bone ◽

Bone Sarcomas ◽

Malignant And Benign Tumors

Abstract Background Karyopherin α 2 (KPNA2), a member of the Karyopherin α family, has been observed in several cancers but lack substantial investigation in malignant bone tumors. The purpose of the current study was to evaluate KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and their malignant bone tumor mimickers, such as chondrosarcomas and Ewing sarcomas.Method We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin embedded surgical specimens from 217 patients with malignant and benign tumors of bone, including 81 osteosarcomas, 42 chondrosarcomas, 9 Ewing sarcomas, 28 osteoid osteoma, 20 osteochondroma and 37 Chondroblastoma. Immunoreactivity was scored semi quantitatively based on stain extent and intensity.Results Seventy one of 81 (87.7%) osteosarcomas, zero of 42 (0%) chondrosarcomas and one of 9 (11.1%) Ewing sarcomas showed immunoreactivity for KPNA2. Negative KPNA2 expression was observed in all of benign bone tumors. Much more positive expression of KPNA2 was found in osteosarcomas as compared with chondrosarcomas and Ewing sarcomas. The sensitivity and specificity of KPNA2 immuno-expression for osteosarcoma was 87.7% and 100%, respectively. In several subtypes of osteosarcomas, immunohistochemical expression of KNA2 was more frequent in osteoblastic (94.5%), with 39 (70.9%) showing strong-intensity staining. KPNA2 positivity was observed in eleven of 13 (84.6%) chondroblastic, three of 6 (50%) fibroblastic, three of 4 (75%) telangiectatic and two of 3 (66.7%) giant cell-rich osteosarcoma. Stronger-intensity staining was observed in osteoblastic osteosarcoma.Conclusion KPNA2 is most frequently expressed in osteosarcomas, particularly in osteoblastic and chondroblastic tumors, but is rarely positive in chondrosarcomas and Ewing sarcomas. This feature may have diagnostic value since it is very useful for distinguishing between osteosarcomas and other bone sarcomas mimickers. This report supports KPNA2 as a novel marker for the diagnosis of osteosarcoma.

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Demographic, clinico-pathological features and management pattern of primary bone tumors in a tertiary care hospital of South India

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20214962 ◽

2021 ◽

Vol 8 (1) ◽

pp. 60

Author(s):

Subbiah Shanmugam ◽

Sujay Susikar ◽

Bharanidharan T. ◽

Arun Victor Jebasingh

Keyword(s):

Bone Tumor ◽

Bone Tumors ◽

Tertiary Care ◽

Tumor Location ◽

Care Hospital ◽

Pathological Features ◽

Primary Bone Tumor ◽

Primary Bone Tumors ◽

True Incidence ◽

Primary Bone

Background: Primary bone tumors are very rare tumors. The true incidence of bone tumors is not well established and is under reported due to rarity and lack of accurate registries. Hence it is essential to study about the demographic, clinico-pathological features and the pattern of surgical management of bone tumors. The aim of this study is to analyze the demographic and clinico-pathological features of primary bone tumors that were managed by surgery.Methods: A retrospective analysis of all patients with primary bone tumor who were treated by surgery from 2012 to 2019 was done. The age, sex distribution, histopathology, location of the tumor and surgical procedure done were analyzed.Results: Among 103 patients analyzed, 66 (64%) were men and 37 (36%) were women. Primary bone tumors most commonly presented in 11 to 20 years of age with 35 (33.9%) patients occurring in this age group. Osteosarcoma was the most common primary bone tumor and it occurred in 49 (47.6%) patients, out of which 34 (69.3%) patients were below 20 years of age. Giant cell tumor was the most common benign bone tumor and it occurred in 22 patients, out of which nine (40.9%) patients were of age 21 to 30 years. Distal femur was the most common site with 39 (37.9%) patients. The limb preservation rate for malignant appendicular bone tumors was 69.0%.Conclusions: The diagnosis of bone tumor depends not only on histopathological features but also needs correlation with age, clinical features, tumor location and radiological features for confirmation of diagnosis.

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A Comparative Study of Periosteal New-Bone Response in Metastatic Bone Tumors (Solitary) and Primary Bone Sarcomas

Radiology ◽

10.1148/92.4.705 ◽

1969 ◽

Vol 92 (4) ◽

pp. 705-708 ◽

Cited By ~ 15

Author(s):

Alex Norman ◽

Richard Ulin

Keyword(s):

Comparative Study ◽

Bone Tumors ◽

Bone Response ◽

Bone Sarcomas ◽

Primary Bone

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Primary bone sarcomas in patients over 40 years of age: A retrospective study using data from the Bone Tumor Registry of Japan

Journal of Orthopaedic Science ◽

10.1016/j.jos.2017.03.008 ◽

2017 ◽

Vol 22 (4) ◽

pp. 749-754 ◽

Cited By ~ 4

Author(s):

Akihito Nagano ◽

Daichi Ishimaru ◽

Yutaka Nishimoto ◽

Haruhiko Akiyama ◽

Akira Kawai

Keyword(s):

Retrospective Study ◽

Bone Tumor ◽

Tumor Registry ◽

Bone Sarcomas ◽

Primary Bone ◽

Using Data ◽

Over 40 Years

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Reconstruction of C-1 lateral mass with titanium mesh cage after resection of an aneurysmal bone cyst of the atlas

Journal of Neurosurgery Spine ◽

10.3171/2008.10.spi08403 ◽

2009 ◽

Vol 10 (2) ◽

pp. 117-121 ◽

Cited By ~ 13

Author(s):

Vincent Y. Wang ◽

Vedat Deviren ◽

Christopher P. Ames

Keyword(s):

Bone Cyst ◽

Benign Tumors ◽

Bone Cysts ◽

Lateral Mass ◽

Titanium Mesh ◽

Titanium Mesh Cage ◽

Primary Bone Tumors ◽

Aneurysmal Bone Cysts ◽

Mesh Cage ◽

Primary Bone

Aneurysmal bone cysts (ABCs) are rare benign tumors with a prevalence of 0.14 cases per 100,000 people. A majority of cases arise during adolescence, and there is a female predominance. This lesion accounts for 1.4% of all primary bone tumors. Aneurysmal bone cysts occur mainly in the long bones, with spinal involvement in 10–30% of cases. Cervical spine ABCs account for about one-third of spinal ABCs, and atlas involvement occurs in 1% of cases. Resection of ABCs at the atlas is difficult because of the location and the lack of proper instrumentation for reconstruction of C-1. The authors present a case of an ABC at C-1 in a child who underwent resection of the lesion and reconstruction of the lateral mass with a titanium mesh cage.

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Primary aggressive chondroblastoma of the tibia

Galician Medical Journal ◽

10.21802/gmj.2020.2.1 ◽

2020 ◽

Vol 27 (2) ◽

pp. E202021

Author(s):

Reda Badaoui ◽

Amine Elmaqrout ◽

Mohamed Boussaidan ◽

Jalal Mekaoui ◽

Jalal Boukhriss ◽

...

Keyword(s):

Young Adults ◽

Soft Tissue ◽

Malignant Transformation ◽

Bone Tumor ◽

Bone Tumors ◽

Benign Tumor ◽

Primary Bone Tumor ◽

Proven Case ◽

Primary Bone ◽

Ossification Centers

Chondroblastoma is a primary bone tumor in children, adolescents and young adults, which accounts for 1% of all bone tumors. Epiphyseal or epiphysometaphyseal localization, this lesion usually develops from secondary ossification centers close to the knee, shoulder and hip. Although chondroblastoma is a nonaggressive benign tumor, it can very rarely show a locally aggressive character or a malignant transformation or even metastases. We describe a histologically proven case of an aggressive, primary chondroblastoma of the tibia invading soft tissue in a 22-year-old girl.

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Lymphography in Bone and Soft Tissue Sarcomas. Experiences from Three Institutions

Tumori Journal ◽

10.1177/030089168006600606 ◽

1980 ◽

Vol 66 (6) ◽

pp. 721-728 ◽

Cited By ~ 2

Author(s):

Kaj Tallroth ◽

Francisco Makai ◽

Renato Musumeci

Keyword(s):

Lymph Node ◽

Soft Tissue ◽

Diagnostic Accuracy ◽

Bone Tumors ◽

Soft Tissue Sarcomas ◽

Hematogenous Spread ◽

Primary Bone Tumor ◽

Bone Sarcomas ◽

Neurogenic Sarcoma ◽

Primary Bone

The case material was collected from 3 Institutions with a total of 411 patients: 217 with primary bone tumor and 224 with soft tissue sarcomas. In the majority of patients lymphography was performed during the initial diagnostic workup. The lymphograms were interpreted as negative or positive for metastases. In bone tumors, the incidence of metastases was 21 %, ranging from 28 % for osteosarcoma to 18 % for Ewing's sarcoma and 13 % for chondrosarcoma. In tumors of the soft tissue, the frequency was somewhat higher (28%), with special regard to rhabdomyosarcoma (53%), anaplastic sarcoma (67 %), neurogenic sarcoma (42%) and synovial sarcoma (35%). In the group of bone sarcomas, primary hematogenous spread was 3 times more frequent than lymphogenous spread, while in soft tissue sarcomas, with a higher incidence of lymphatic spread, this finding was inverted. In the more consistent tumor groups, the occurrence of lymphatic metastases indicated a significant worsening of the prognosis. In 96 patients, lymph node biopsies were performed and the radiologic histologic correlation gave evidence of a 91.7 % overall diagnostic accuracy.

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Rare Primary Malignant Bone Sarcomas

Cancers ◽

10.3390/cancers12113092 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3092

Author(s):

Emanuela Palmerini ◽

Alberto Righi ◽

Eric L. Staals

Keyword(s):

Ewing Sarcoma ◽

Bone Tumors ◽

Spindle Cell ◽

Clinical Aspects ◽

Vascular Tumors ◽

Nerve Sheath Tumor ◽

Round Cell ◽

Primary Bone Tumors ◽

Bone Sarcomas ◽

Primary Bone

Rare primary malignant bone sarcomas (RPMBS), other than osteosarcoma, chondrosarcoma, chordoma, and Ewing sarcoma, account for about 5–10% of primary bone tumors and represent a major diagnostic challenge. These tumors include spindle cell and round cell sarcoma entities, hemangiopericytoma-like and vascular tumors. Additionally, several histotypes, traditionally described in the soft tissues, such as myxofibrosarcoma, synovial sarcoma, and malignant peripheral nerve sheath tumor of bone, have been reported in patients with primary bone tumors. While wide surgical resection is the mainstay of local treatment, systemic therapy of these rare entities is controversial. Patients with undifferentiated spindle cell or pleomorphic high-grade tumors of bone, are usually treated with osteosarcoma-like chemotherapy, while patients with round cell and undifferentiated round cell tumors (URCTs), may respond to sarcoma treatment regimens for Ewing sarcoma patients. Studies on analogies and differences among these ultra-rare tumors have seldom been reported. This review describes relevance, clinical aspects, diagnostic procedures, staging, treatment recommendations, and current research in this composite tumor group.

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Malignant Osteoid Matrix Bone Tumors

Musculoskeletal Imaging Volume 1 ◽

10.1093/med/9780190938161.003.0053 ◽

2019 ◽

pp. 251-258

Author(s):

Abhijit Datir

Keyword(s):

Bone Tumor ◽

Bone Tumors ◽

Age Groups ◽

Bone Destruction ◽

Tissue Mass ◽

Primary Bone Tumor ◽

Radiologic Findings ◽

Conventional Osteosarcoma ◽

Skip Lesions ◽

Primary Bone

Chapter 53 discusses malignant osteoid matrix bone tumors and focuses on several types of osteosarcoma, ranging from the most common, conventional osteosarcoma, to secondary osteosarcomas, such as Paget and postradiation sarcomas. Osteosarcoma is the most common primary bone tumor in children and adolescents, and second most frequent primary malignant bone tumor if all age groups are considered. A short discussion on typical radiologic findings with classic examples of various types of osteosarcoma is included. Conventional radiographs show an aggressive lesion with permeative bone destruction, extraosseous soft tissue mass and cortical disruption with periosteal reaction. MRI is useful for assessing tumor extent and skip lesions. Treatment includes surgery and chemotherapy.

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