scholarly journals Substantia Nigra Volumetry with 3-T MRI in De Novo and Advanced Parkinson Disease

Radiology ◽  
2020 ◽  
Vol 296 (2) ◽  
pp. 401-410
Author(s):  
Paolo Vitali ◽  
Marina I. Pan ◽  
Fulvia Palesi ◽  
Giancarlo Germani ◽  
Arianna Faggioli ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Parkinson Disease ◽  
De Novo

Retinal thinning associates with nigral dopaminergic loss in de novo Parkinson disease

Neurology ◽  
2018 ◽  
Vol 91 (11) ◽  
pp. e1003-e1012 ◽  
Author(s):  
Jeeyun Ahn ◽  
Jee-Young Lee ◽  
Tae Wan Kim ◽  
Eun Jin Yoon ◽  
Sohee Oh ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Parkinson Disease ◽  
False Discovery Rate ◽  
Layer Thickness ◽  
De Novo ◽  
Retinal Layer ◽  
Yahr Stage ◽  
False Discovery ◽  
Study Circle ◽  
Retinal Thinning

ObjectiveTo analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD).MethodsForty-nine patients with PD and 54 age-matched controls were analyzed. Ophthalmologic examination and macula optical coherence tomography scans were performed with additional microperimetry, N-(3-[18F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane PET, and 3T MRI scans were done in patients with PD only. Retinal layer thickness and volume were measured in subfields of the 1-, 2.22-, and 3.45-mm Early Treatment of Diabetic Retinopathy Study circle and compared in patients with PD and controls. Correlation of inner retinal layer thinning with microperimetric response was examined in patients with PD, and the relationships between retinal layer thickness and dopamine transporter densities in the ipsilateral caudate, anterior and posterior putamen, and substantia nigra were analyzed.ResultsRetinal layer thinning was observed in the temporal and inferior 2.22-mm sectors (false discovery rate–adjusted p < 0.05) of drug-naive patients with PD, particularly the inner plexiform and ganglion cell layers. The thickness of these layers in the inferior 2.22-mm sector showed a negative correlation with the Hoehn and Yahr stage (p = 0.032 and 0.014, respectively). There was positive correlation between macular sensitivity and retinal layer thickness in all 3.45-mm sectors, the superior 2.22-mm sector, and 1-mm circle (p < 0.05 for all). There was an association between retinal thinning and dopaminergic loss in the left substantia nigra (false discovery rate–adjusted p < 0.001).ConclusionRetinal thinning is present in the early stages of PD, correlates with disease severity, and may be linked to nigral dopaminergic degeneration. Retinal imaging may be useful for detection of pathologic changes occurring in early PD.

scholarly journals High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease

Neurology ◽  
2009 ◽  
Vol 72 (16) ◽  
pp. 1378-1384 ◽  
Author(s):  
D. E. Vaillancourt ◽  
M. B. Spraker ◽  
J. Prodoehl ◽  
I. Abraham ◽  
D. M. Corcos ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
High Resolution ◽  
Substantia Nigra ◽  
Parkinson Disease ◽  
De Novo ◽  
Diffusion Tensor

scholarly journals Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson disease

2021 ◽  
Author(s):  
Lu Wang ◽  
Yayun Yan ◽  
Liyao Zhang ◽  
Yan Liu ◽  
Ruirui Luo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Parkinson Disease ◽  
Clinical Symptoms ◽  
Dopamine Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Resonance Imaging ◽  
Mean Values

AbstractNeuromelanin (NM) is a dark pigment that mainly exists in neurons of the substantia nigra pars compacta (SNc). In Parkinson disease (PD) patients, NM concentration decreases gradually with degeneration and necrosis of dopamine neurons, suggesting potential use as a PD biomarker. We aimed to evaluate associations between NM concentration in in vivo SN and PD progression and different motor subtypes using NM magnetic resonance imaging (NM-MRI). Fifty-four patients with idiopathic PD were enrolled. Patients were divided into groups by subtypes with different clinical symptoms: tremor dominant (TD) group and postural instability and gait difficulty (PIGD) group. Fifteen healthy age-matched volunteers were enrolled as controls. All subjects underwent clinical assessment and NM-MRI examination. PD patients showed significantly decreased contrast-to-noise ratio (CNR) values in medial and lateral SN (P < 0.05) compared to controls. CNR values in lateral SN region decreased linearly with PD progression (P = 0.001). PIGD patients showed significant decreases in CNR mean values in lateral SN compared to TD patients (P = 0.004). Diagnostic accuracy of using lateral substantia nigra (SN) in TD and PIGD groups was 79% (sensitivity 76.5%, specificity 78.6%). NM concentration in PD patients decreases gradually during disease progression and differs significantly between PD subtypes. NM may be a reliable biomarker for PD severity and subtype identification.

scholarly journals Utility of manual fractional anisotropy measurements in the management of patients with Parkinson disease: a feasibility study with a 1.5-T magnetic resonance imaging system

2021 ◽  
Vol 10 (2) ◽  
pp. 205846012199347
Author(s):  
Romulo V de Oliveira ◽  
João S Pereira
Keyword(s):  
Diffusion Tensor Imaging ◽  
Substantia Nigra ◽  
Parkinson Disease ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Neuronal Damage ◽  
Magnetic Resonance Imaging System ◽  
Healthy Controls ◽  
Clinical Variables ◽  
Severity Scores

Background Diffusion tensor imaging has emerged as a promising tool for quantitative analysis of neuronal damage in Parkinson disease, with potential value for diagnostic and prognostic evaluation. Purpose The aim of this study was to examine Parkinson disease-associated alterations in specific brain regions revealed by diffusion tensor imaging and how such alterations correlate with clinical variables. Material and Methods Diffusion tensor imaging was performed on 42 Parkinson disease patients and 20 healthy controls with a 1.5-T scanner. Manual fractional anisotropy measurements were performed for the ventral, intermediate, and dorsal portions of the substantia nigra, as well as for the cerebral peduncles, putamen, thalamus, and supplementary motor area. The correlation analysis between these measurements and the clinical variables was performed using χ2 variance and multiple linear regression. Results Compared to healthy controls, Parkinson disease patients had significantly reduced fractional anisotropy values in the substantia nigra ( P < .05). Some fractional anisotropy measurements in the substantia nigra correlated inversely with duration of Parkinson disease and Parkinson disease severity scores. Reduced fractional anisotropy values in the substantia nigra were also correlated inversely with age variable. fractional anisotropy values obtained for the right and left putamen varied significantly between males and females in both groups. Conclusion Manual fractional anisotropy measurements in the substantia nigra were confirmed to be feasible with a 1.5-T scanner. Diffusion tensor imaging data can be used as a reliable biomarker of Parkinson disease that can be used to support diagnosis, prognosis, and progression/treatment monitoring.

scholarly journals Thalamic Projection Fiber Integrity in de novo Parkinson Disease

2012 ◽  
Vol 34 (1) ◽  
pp. 74-79 ◽  
Author(s):  
P.J. Planetta ◽  
E.T. Schulze ◽  
E.K. Geary ◽  
D.M. Corcos ◽  
J.G. Goldman ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
De Novo
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