Real-time Assessment of Right and Left Ventricular Volumes and Function in Patients with Congenital Heart Disease by Using High Spatiotemporal Resolution Radial k-t SENSE

AbstractObjective:Left ventricular non-compaction is an architectural abnormality of the myocardium, associated with heart failure, systemic thromboembolism, and arrhythmia. We sought to assess the prevalence of left ventricular non-compaction in patients with single ventricle heart disease and its effects on ventricular function.Methods:Cardiac MRI of 93 patients with single ventricle heart disease (mean age 24 ± 8 years; 55% male) from three tertiary congenital centres was retrospectively reviewed; 65 of these had left ventricular morphology and are the subject of this report. The presence of left ventricular non-compaction was defined as having a non-compacted:compacted (NC:C) myocardial thickness ratio >2.3:1. The distribution of left ventricular non-compaction, ventricular volumes, and function was correlated with clinical data.Results:The prevalence of left ventricular non-compaction was 37% (24 of 65 patients) with a mean of 4 ± 2 affected segments. The distribution was apical in 100%, mid-ventricular in 29%, and basal in 17% of patients. Patients with left ventricular non-compaction had significantly higher end-diastolic (128 ± 44 versus 104 ± 46 mL/m2, p = 0.047) and end-systolic left ventricular volumes (74 ± 35 versus 56 ± 35 mL/m2, p = 0.039) with lower left ventricular ejection fraction (44 ± 11 versus 50 ± 9%, p = 0.039) compared to those with normal compaction. The number of segments involved did not correlate with ventricular function (p = 0.71).Conclusions:Left ventricular non-compaction is frequently observed in patients with left ventricle-type univentricular hearts, with predominantly apical and mid-ventricular involvement. The presence of non-compaction is associated with increased indexed end-diastolic volumes and impaired systolic function.

Download Full-text

Acoustic Quantification of Left Ventricular Volumes and Function in Children With Congenital and Acquired Heart Disease.

Echocardiography ◽

10.1111/j.1540-8175.1995.tb00530.x ◽

1995 ◽

Vol 12 (2) ◽

pp. 121-127 ◽

Cited By ~ 1

Author(s):

ZIYAD M. HIJAZI ◽

QI-LING CAO ◽

ROBERT GEGGEL ◽

STEVEN L. SCHWARTZ ◽

GERALD R. MARX ◽

...

Keyword(s):

Heart Disease ◽

Left Ventricular ◽

Left Ventricular Volumes ◽

Ventricular Volumes ◽

Acoustic Quantification ◽

Acquired Heart Disease ◽

And Function

Download Full-text

Genetics of cardiomyopathies: left ventricular non-compaction

ESC CardioMed ◽

10.1093/med/9780198784906.003.0156_update_001 ◽

2018 ◽

pp. 697-699

Author(s):

Eloisa Arbustini ◽

Alessandro Di Toro ◽

Lorenzo Giuliani ◽

Nupoor Narula ◽

Valentina Favalli

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Healthy Subjects ◽

Congenital Heart ◽

Left Ventricular ◽

Individual Variability ◽

Left Ventricular Dilation ◽

Normal Left Ventricular ◽

And Function ◽

Ventricular Trabeculae

Left ventricular non-compaction (LVNC) describes a ventricular wall anatomy, characterized by prominent left ventricular trabeculae, a thin compacted layer, and deep intertrabecular recesses. Individual variability is extreme. The trabecular configuration represents a type of individual dynamic ‘cardioprinting’. On its own, the diagnosis of LVNC does not coincide with that of a ‘cardiomyopathy’ because it can be observed in healthy subjects with normal left ventricular size and function, and it can be acquired and reversible. Rarely, LVNC is intrinsically part of a cardiomyopathy: the paradigmatic examples are infantile tafazzinopathies. The prevalence of LVNC in healthy athletes, its possible reversibility, and increasing diagnosis in healthy subjects suggest cautious use of the term LVNC cardiomyopathy, which describes the morphology, but not the functional profile of the cardiomyopathy or the associated congenital disease. Therefore, when associated with left ventricular dilation and dysfunction, hypertrophy, or congenital heart disease, the leading diagnosis is cardiomyopathy or congenital heart disease followed by the addition of the descriptor LVNC.

Download Full-text