scholarly journals Correlation of Carotid Plaque Neovascularization Detected by Using Contrast-enhanced US with Clinical Symptoms

Radiology ◽  
2009 ◽  
Vol 251 (2) ◽  
pp. 583-589 ◽  
Author(s):  
Li Xiong ◽  
You-Bin Deng ◽  
Ying Zhu ◽  
Ya-Ni Liu ◽  
Xiao-Jun Bi
Keyword(s):  
Carotid Plaque ◽  
Clinical Symptoms ◽  
Contrast Enhanced

Abstract 11733: Assessment of Carotid Plaque Neovascularization Using Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging is Useful for Risk Stratification in Patients With Coronary Artery Disease

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Jun Nakamura ◽  
Takamitsu Nakamura ◽  
Juntaro Deyama ◽  
Daisuke Fujioka ◽  
Ken-ichi Kawabata ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Quantitative Analysis ◽  
Carotid Artery ◽  
Carotid Plaque ◽  
Contrast Enhanced Ultrasound ◽  
Baseline Model ◽  
Contrast Enhanced ◽  
Traditional Risk Factors ◽  
Artery Disease

Introduction: Extensive neovascularization in atherosclerotic plaque has been shown to be associated with plaque progression and instability, leading to atherosclerotic cardiovascular events. Contrast-enhanced ultrasound (CEUS) of the carotid artery is a potential technique for imaging plaque neovascularization. Hypothesis: Assessment of intra-plaque neovascularization of the carotid artery using quantitative analysis of CEUS provides prognostic information in patients with coronary artery disease (CAD). Methods: This study included 206 patients with stable CAD and with carotid intima-media thickness (IMT) > 1.1 mm. They underwent a CEUS examination of the carotid artery and were followed-up prospectively for < 38 months or until a cardiac event (cardiac death, non-fatal myocardial infarction [MI], unstable angina pectoris [uAP] requiring unplanned coronary revascularization, or heart failure requiring hospitalization). The degree of contrast signals measured within the carotid plaque after the intravenous injection of contrast material was quantified by calculating the increase in mean gray scale level within the region of interest of the carotid plaque, expressed as plaque enhanced intensity. Results: During the follow-up period (3 - 38 months, mean 22.8 ± 11.8 months), 31 events occurred (2 cardiac deaths, 7 non-fatal MIs, 16 uAP, and 6 heart failure). Multivariate Cox proportional hazards analysis showed that plaque enhanced intensity was a significant predictor of cardiac events independent of traditional risk factors (HR, 1.52; 95% CI, 1.20 - 1.94; p = 0.001). The addition of plaque enhanced intensity had a significant incremental effect on the area under the ROC curve (AUC) generated using baseline model of traditional risk factors (AUC: baseline model 0.69 vs. baseline model + plaque enhanced intensity 0.78, p = 0.03). The addition of the plaque enhanced intensity to the baseline risk factors resulted in net reclassification improvement (NRI) and integrated discrimination improvement (IDI) (NRI 0.58, p = 0.003; and IDI 0.078, p = 0.03). Conclusions: The assessment of carotid plaque neovascularization using quantitative analysis of CEUS may be useful for risk stratification in patients with CAD.

scholarly journals Neuroendocrine tumor of the small intestine diagnosed with trans-abdominal ultrasonography: A case report

2020 ◽  
Author(s):  
Kazuma Tsujimura ◽  
Yasukatsu Takushi ◽  
Atsushi Nakachi ◽  
Tsuyoshi Teruya ◽  
Kouji Iha
Keyword(s):  
Small Intestine ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumor ◽  
Clinical Symptoms ◽  
Abdominal Ultrasonography ◽  
Node Metastasis ◽  
Tumor Lesion ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography

Tumors of the small intestine are rare. In addition, clinical symptoms are nonspecific and neoplasm-related symptoms occur late. We report a case of neuroendocrine tumor (NET) of the small intestine that was diagnosed early with trans-abdominal ultrasonography (US). The patient was a 61-year-old man. Abdominal contrast-enhanced computed tomography (CT) was performed because the patient complained of abdominal pain. The CT showed a tumor lesion in the mesentery. Trans-abdominal US was undertaken to evaluate this tumor lesion, and a tumor lesion of the small intestine was found nearby. A diagnosis of lymph-node metastasis of a small-intestine tumor was made as a preoperative diagnosis. A laparotomy was performed with partial resection of the ileum, together with the small-intestine mesentery including an enlarged lymph node. Histological examination revealed NET of the ileum and lymph-node metastasis. Trans-abdominal US is useful in the diagnosis of small-intestine NET.

Fully Automated Carotid Plaque Segmentation in Combined Contrast-Enhanced and B-Mode Ultrasound

2015 ◽  
Vol 41 (2) ◽  
pp. 517-531 ◽  
Author(s):  
Zeynettin Akkus ◽  
Diego D.B. Carvalho ◽  
Stijn C.H. van den Oord ◽  
Arend F.L. Schinkel ◽  
Wiro J. Niessen ◽  
...  
Keyword(s):  
Carotid Plaque ◽  
Contrast Enhanced

Assessment of Disease Activity in Takayasu Arteritis: Potential Role of Contrast-Enhanced Ultrasound

2019 ◽  
Vol 40 (05) ◽  
pp. 638-645 ◽  
Author(s):  
Christian Lottspeich ◽  
Claudia Dechant ◽  
Anton Köhler ◽  
Maximilian Tischler ◽  
Karla Maria Treitl ◽  
...  
Keyword(s):  
High Resolution ◽  
Disease Activity ◽  
Takayasu Arteritis ◽  
Clinical Symptoms ◽  
Inactive Disease ◽  
Contrast Enhanced Ultrasound ◽  
Acute Phase Reactants ◽  
Contrast Enhanced ◽  
Assessment Of Disease Activity ◽  
Active Disease

Abstract Purpose To assess the diagnostic value of intima media thickness measurements and contrast-enhanced ultrasound (CEUS) of the supraaortic arteries in the assessment of disease activity in Takayasu arteritis (TA). Materials and Methods Patients with TA and involvement of the carotid and/or subclavian/axillary arteries underwent CEUS imaging in addition to B-mode and color duplex ultrasound. The maximum IMT (mIMT) was measured and high-resolution CEUS of the most prominently thickened vessel segment was performed. Two blinded readers reviewed the CEUS movies, with semiquantitative assessment of microbubble enhancement of the arterial wall (grade 0: no or minimal; grade 1: moderate; grade 2: pronounced). Clinical symptoms, acute phase reactants, and established indices of clinical disease activity (NIH criteria, ITAS score) were recorded. Results 40 examinations in 17 patients were analyzed. According to clinical judgement, 27 and 13 cases were classified as clinically inactive and active, respectively. An mIMT-cutoff of > 2.7 mm identified active disease with a sensitivity and specificity of 69.2 % and 88.9 %, respectively (area under the curve 0.83). The interobserver agreement of CEUS analysis was substantial (Cohen’s kappa 0.76). By consensus reading, 17, 15, and 8 cases were classified as uptake grade 0, grade 1 and grade 2, respectively. Grade 0 uptake was exclusively present in 17 clinically inactive patients. Grade 1 uptake was seen in 10 patients with clinically inactive disease and 5 patients with clinically active disease. Grade 2 uptake was exclusively present in 8 patients with active disease. Conclusion Both sonographic IMT measurements and high-resolution CEUS are promising in the ad-hoc assessment of disease activity in patients with TA.

scholarly journals Comparison of Carotid Plaque Ulcer Detection Using Contrast-Enhanced and Time-of-Flight MRA Techniques

2012 ◽  
Vol 34 (1) ◽  
pp. 177-184 ◽  
Author(s):  
M. Etesami ◽  
Y. Hoi ◽  
D.A. Steinman ◽  
S.K. Gujar ◽  
A.E. Nidecker ◽  
...  
Keyword(s):  
Carotid Plaque ◽  
Time Of Flight ◽  
Contrast Enhanced ◽  
Ulcer Detection

scholarly journals Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis?

2007 ◽  
Vol 12 (4) ◽  
pp. 291-297 ◽  
Author(s):  
Falak Shah ◽  
Prakash Balan ◽  
Matthew Weinberg ◽  
Vijaya Reddy ◽  
Rachel Neems ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Carotid Plaque ◽  
Surrogate Marker ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

Mesenteric Masses on 2D Mode and Contrast-Enhanced Ultrasound: A Retrospective Study in 69 Patients

2017 ◽  
Vol 38 (06) ◽  
pp. 655-660
Author(s):  
Corinna Trenker ◽  
Ehsan Zadeh ◽  
Golo Petzold ◽  
Christian Görg ◽  
Albrecht Neesse
Keyword(s):  
Retrospective Study ◽  
Clinical Data ◽  
Clinical Symptoms ◽  
Contrast Enhanced Ultrasound ◽  
Definite Diagnosis ◽  
Inflammation Markers ◽  
Diagnostic Dilemma ◽  
Contrast Enhanced ◽  
Histological Confirmation

Abstract Purpose Detection of mesenteric masses (MM) by 2 D ultrasound often causes a diagnostic dilemma, and histological confirmation is required for definite diagnosis. The value of contrast-enhanced ultrasound (CEUS) for the diagnosis of MMs has not been investigated before. Here, we retrospectively evaluate 2D-mode and CEUS patterns of 69 patients with histologically confirmed MMs. Materials and Methods Between January 2006 and January 2016, n = 69 patients were included in the study. Histopathological data, clinical data, 2D-mode ultrasound and CEUS enhancement were retrospectively analyzed. Results More than half of the MMs (n = 47/69, 68 %) revealed a malignant histology. The size of the MM, inflammation markers and clinical symptoms did not correlate with the histological outcome. 2 D mode revealed n = 46 (67 %) lesions as hypoechoic, n = 14 (20 %) as hyperechoic, and n = 9 (13 %) with a complex echo pattern. Hypoechogenicity and complex echo patterns as well as regular borders of MMs were significantly associated with malignancy (p < 0.05). On CEUS, malignant MMs showed arterial hyperenhancement (n = 11/47, 23 %), isoenhancement (n = 25/47, 52 %) and hypoenhancement (n = 7/47, 15 %). The majority of malignant MMs (n = 42/47, 89 %) revealed parenchymal hypoenhancement. Benign masses revealed arterial hyperenhancement in n = 1/22 (5 %), isoenhancement in n = 8/22 (36 %), and hypoenhancement in n = 10/22 (45 %). The majority of lesions showed parenchymal hypoenhancement (n = 19/22, 86 %). Conclusion Hypoechogenicity and complex echogenicity in 2 D mode, irregular borders, and parenchymal wash-out were more often associated with malignancy. However, CEUS did not help to subclassify malignant MMs according to their histological entity.

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