Perivenous Hepatic Iron Deposition in Alcoholic                     Cirrhosis

Abstract In patients with spontaneous chronic low plasma latent iron-binding capacity, a large fraction of the intestinally absorbed iron is deposited in the liver without prior appearance in the systemic plasma. Such hepatic iron is not released to any large extent during the subsequent 2 weeks. Our results are consistent with the hypothesis that iron absorbed from the intestinal tract is not initially bound to transferrin. When the plasma latent iron-binding capacity is normal, iron binds to transferrin prior to reaching the liver; when the plasma latent iron-binding capacity is low, a portion of the iron reaches the liver either unbound or abnormally bound to transferrin, resulting in its immediate hepatic deposition.

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Hepatic iron deposition in patients with sickle cell disease: Role of breath-hold multiecho T2∗-weighted MRI sequence

The Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1016/j.ejrnm.2014.05.002 ◽

2014 ◽

Vol 45 (3) ◽

pp. 651-655 ◽

Cited By ~ 1

Author(s):

Fatma Mohamed Awad ◽

Shereen Ahmed Alshazly

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Iron Deposition ◽

Breath Hold ◽

Hepatic Iron ◽

Cell Disease

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Comparison of Computerized Image Analysis with Traditional Semiquantitative Scoring of Perls’ Prussian Blue Stained Hepatic Iron Deposition

Toxicologic Pathology ◽

10.1177/0192623313476576 ◽

2013 ◽

Vol 41 (7) ◽

pp. 992-1000 ◽

Cited By ~ 12

Author(s):

A. Peter Hall ◽

Wendy Davies ◽

Katie Stamp ◽

Isabel Clamp ◽

Alison Bigley

Keyword(s):

Image Analysis ◽

Prussian Blue ◽

Iron Deposition ◽

Hepatic Iron ◽

Computerized Image Analysis

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Value of Abdominal Susceptibility-Weighted Magnetic Resonance Imaging for Quantitative Assessment of Hepatic Iron Deposition in Patients with Chronic Hepatitis B: Comparison with Serum Iron Markers

Journal of International Medical Research ◽

10.1177/147323001204000319 ◽

2012 ◽

Vol 40 (3) ◽

pp. 1005-1015 ◽

Cited By ~ 5

Author(s):

W Lv ◽

F Yan ◽

M Zeng ◽

J Zhang ◽

Y Yuan ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Chronic Hepatitis ◽

Magnetic Resonance ◽

Serum Iron ◽

Hbv Infection ◽

Iron Deposition ◽

Hepatic Iron ◽

Healthy Controls ◽

Resonance Imaging ◽

Weighted Magnetic Resonance Imaging

OBJECTIVE: To assess hepatic iron deposition quantitatively in patients with chronic hepatitis B (HBV) infection, using abdominal susceptibility-weighted magnetic resonance imaging (SWI). METHODS: Patients with HBV infection and healthy controls underwent abdominal SWI and were assessed for serum iron markers. Phase values were measured and five grades of hepatic iron deposition were described by SWI. RESULTS: Patients with HBV infection ( n = 327) and healthy controls ( n = 50) were prospectively enrolled. In total, 77 (25.4%) patients with HBV infection had hepatic iron deposition as determined by SWI. Phase values were significantly different between patients with hepatic iron deposition compared with patients without hepatic iron deposition or controls, and were significantly different across different grades of hepatic iron deposition. Serum iron, ferritin, transferrin and transferrin saturation were significantly higher in patients with, versus those without, hepatic iron deposition. Only serum ferritin was significantly different across different grades of hepatic iron deposition, and there was a low inverse correlation between serum ferritin and phase values. CONCLUSIONS: Compared with serum iron markers, abdominal SWI may represent a powerful tool to assess hepatic iron deposition quantitatively in patients with chronic HBV infection.

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