Bile acid metabolism and circadian rhythms

2020 ◽  
Vol 319 (5) ◽  
pp. G549-G563
Author(s):  
Yunxia Yang ◽  
Jianfa Zhang
Keyword(s):  
Bile Acid ◽  
Energy Metabolism ◽  
Circadian Rhythms ◽  
Acid Metabolism ◽  
Metabolic Diseases ◽  
Nutrient Absorption ◽  
Bile Acid Metabolism ◽  
Future Perspectives ◽  
Circadian Oscillators ◽  
Regulate Energy Metabolism

Circadian rhythms are biological systems that synchronize cellular circadian oscillators and regulate nutrient absorption and utilization. Bile acids are important modulators that facilitate nutrient absorption and regulate energy metabolism. Bile acid metabolism and circadian rhythms are related to metabolic diseases, and their intersections have not been summarized clearly up to now. This review summarizes the molecular association between circadian rhythms and bile acid metabolism and points out future perspectives and potential therapeutic targets in metabolic diseases.

Abstract 49: The Transcriptional Repressor MafG Regulates Cholesterol Catabolism

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Thomas Q de Aguiar Vallim ◽  
Elizabeth J Tarling ◽  
Hannah Ahn ◽  
Lee R Hagey ◽  
Casey E Romanoski ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Metabolism ◽  
Metabolic Diseases ◽  
Cholesterol Metabolism ◽  
Transcriptional Repressor ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Metabolism ◽  
Biliary Bile Acid

Elevated circulating cholesterol levels is a major risk factor for cardiovascular diseases (CVD), and therefore understanding pathways that affect cholesterol metabolism are important for potential treatment of CVD. The major route for cholesterol excretion is through its catabolism to bile acids. Specific bile acids are also potent signaling molecules that modulate metabolic pathways affecting lipid, glucose and bile acid homeostasis. Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis ( Cyp7a1 , Cyp8b1 ) are regulated transcriptionally by the nuclear receptor FXR. We have identified an FXR-regulated pathway upstream of a transcriptional repressor that controls multiple bile acid metabolism genes. We identify MafG as an FXR target gene and show that hepatic MAFG overexpression represses genes of the bile acid synthetic pathway, and modifies the biliary bile acid composition. In contrast, MafG loss-of-function studies cause de-repression of the bile acid genes with concordant changes in biliary bile acid levels. Finally, we identify functional MafG response elements in bile acid metabolism genes using ChIP-Seq analysis. Our studies identify a molecular mechanism for the complex feedback regulation of bile acid synthesis controlled by FXR. The identification of this pathway will likely have important implications in metabolic diseases.

T cell mediated cholangitis alters bile acid metabolism

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
F Glaser ◽  
C John ◽  
B Engel ◽  
B Höh ◽  
S Weidemann ◽  
...  
Keyword(s):  
Bile Acid ◽  
T Cell ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism

2021 ◽  
Author(s):  
Ming-zhi Zhu ◽  
Fang Zhou ◽  
Jian Ouyang ◽  
Qi-ye Wang ◽  
Yi-long Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Low Doses ◽  
Combined Use

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy. The synergistic effect may be attributed to regulation of gut microbiota and BA metabolism.

scholarly journals STUDIES ON BILE ACID METABOLISM

1942 ◽  
Vol 143 (3) ◽  
pp. 771-783
Author(s):  
L.H. Schmidt ◽  
Hettie B. Hughes
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Bile Acid Metabolism
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