Increase in Serum Ribonuclease Activity After Bilateral Nephrectomy

1956 ◽  
Vol 187 (3) ◽  
pp. 525-528 ◽  
Author(s):  
M. Rabinovitch ◽  
S. R. Dohi
Keyword(s):  
Digestive Tract ◽  
Ribonuclease Activity ◽  
Lymphoid Tissues ◽  
Bilateral Nephrectomy ◽  
Serum Activity ◽  
Repeated Doses ◽  
Serum Ribonuclease ◽  
Increased Activity

Serum ribonuclease activity increased after bilateral nephrectomy or hydronephrosis in the rat. This increase could be shown to occur 40 minutes after bilateral nephrectomy and was not abolished by either simultaneous adrenalectomy, pancreatectomy, evisceration or cortisone administration in single or repeated doses. As a similar enzyme was found in the urine, it is suggested that the increased serum activity is due to nonexcretion by the kidneys. The results also indicate that the increased activity did not originate from the digestive tract, pancreas or lymphoid tissues, and that stress did not play a major role in the phenomenon.

Serum ribonuclease activity in the diagnosis of prostate cancer in men with serum prostate-specific antigen levels between 2.5 and 20 ng/mL

2006 ◽  
Vol 39 (4) ◽  
pp. 363-366 ◽  
Author(s):  
Saadettin Yilmaz Eskicorapci ◽  
H. Asuman Özkara ◽  
Evren Önder ◽  
Bulent Akdogan ◽  
İlhan Erkan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Ribonuclease Activity ◽  
Serum Prostate Specific Antigen ◽  
Serum Ribonuclease

scholarly journals Serum ribonuclease activity in cancer patients

1978 ◽  
Vol 38 (2) ◽  
pp. 280-286 ◽  
Author(s):  
R H Kottel ◽  
S O Hoch ◽  
R G Parsons ◽  
J A Hoch
Keyword(s):  
Cancer Patients ◽  
Ribonuclease Activity ◽  
Serum Ribonuclease

MEMORY AND SERUM RIBONUCLEASE ACTIVITY IN THE AGED*

1967 ◽  
Vol 15 (7) ◽  
pp. 629-639 ◽  
Author(s):  
S. Sved ◽  
V. A. Kral ◽  
H. E. Enesco ◽  
L. Solyom ◽  
B. T. Wigdor ◽  
...  
Keyword(s):  
Ribonuclease Activity ◽  
Serum Ribonuclease

DIAGNOSTIC PERFORMANCE OF SERUM RIBONUCLEASE ACTIVITY IN MEN WITH PSA LEVELS BETWEEN 2.5 AND 20 NG/ML

2006 ◽  
Vol 5 (2) ◽  
pp. 274
Author(s):  
S. Eskicorapci ◽  
H.A. Ozkara ◽  
E. Onder ◽  
I. Erkan ◽  
G. Ciliv ◽  
...  
Keyword(s):  
Diagnostic Performance ◽  
Ribonuclease Activity ◽  
Serum Ribonuclease

scholarly journals Significance of abnormal 53BP1 expression as a novel molecular pathologic parameter of follicular-shaped B-cell lymphoid lesions in human digestive tract

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Luong Thi My Hanh ◽  
Katsuya Matsuda ◽  
Daisuke Niino ◽  
Hirokazu Kurohama ◽  
Masahiro Ito ◽  
...  
Keyword(s):  
B Cell ◽  
Digestive Tract ◽  
High Frequency ◽  
Lymphoid Tissues ◽  
Dna Double Strand Breaks ◽  
Tissue Samples ◽  
Class Switch ◽  
Human Digestive Tract ◽  
Follicular Lymphomas ◽  
Tumor Types

AbstractThe digestive tract is a common site of extranodal malignant lymphomas (MLs) and benign lymphoid lesions (BLs). TP53-binding protein 1 (53BP1) expression has been widely investigated in class switch recombination but rarely in human lymphoid tissues with respect to tumorigenesis. We previously reported that immunofluorescence (IF) analysis of 53BP1 nuclear foci (NF), reflecting DNA double strand breaks, is useful for estimating genomic instability in different tumor types. In this study, we evaluated the potential of IF-based analysis of 53BP1 expression in differentiating MLs from BLs. We examined 231 biopsied tissue samples of primary MLs and BLs in the digestive tract. The 53BP1 immunoreactivity pattern was determined by multicolor IF. Compared to BLs, MLs showed a high frequency of abnormal 53BP1 expression (p < 0.0001). Statistically, abnormal 53BP1 expression is an effective test for distinguishing follicular lymphomas from BLs (specificity 98.6%, sensitivity 86.8%) and for distinguishing small B-cell lymphomas from BLs (specificity 98.3%, sensitivity 77.6%). Furthermore, a high frequency of abnormal 53BP1 expression was associated with “high-risk” MALT lymphomas, which exhibited t(11;18)(q21;21) (p = 0.0145). Collectively, these results suggest that IF-based analysis of 53BP1 expression in biopsy samples is a promising technique for diagnosing MLs in the digestive system.

scholarly journals Effect of Endotoxin on the Serum Ribonuclease Activity in Rats

1969 ◽  
Vol 100 (1) ◽  
pp. 550-551 ◽  
Author(s):  
Vera Kutas ◽  
L. Bertök ◽  
L. D. Szabö
Keyword(s):  
Ribonuclease Activity ◽  
Serum Ribonuclease

Serum Ribonuclease Activity

1958 ◽  
Vol 12 (3) ◽  
pp. 473-476 ◽  
Author(s):  
J. C. Houck ◽  
L. B. Berman
Keyword(s):  
Ribonuclease Activity ◽  
Serum Ribonuclease

scholarly journals Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice.

1975 ◽  
Vol 141 (4) ◽  
pp. 918-923 ◽  
Author(s):  
W P Drake ◽  
D R Pokorney ◽  
S Chipman ◽  
C C Levy ◽  
M R Mardiney
Keyword(s):  
Biochemical Marker ◽  
White Blood Cells ◽  
Ribonuclease Activity ◽  
Reticulum Cell ◽  
Neoplastic Disease ◽  
Polyuridylic Acid ◽  
High Incidence ◽  
Elevated Activity ◽  
Old Mice ◽  
Increased Activity

Ribonuclease activity in cell-free thymus homogenates was elevated for five strains of mice genetically predisposed toward leukemia or reticulum cell neoplasms (AKR, C58, PL, RF, and SJL). Such increased activity was directed against polyuridylic acid and was observed in 8-wk old mice, well before the onset of neoplastic transformation. Similarly, white blood cell ribonuclease activity was elevated in mice of the strains AKR, C2H/He, PL and RF. Statistical analysis indicated that such elevated activity in these strains related to their high incidence of spontaneous neoplastic disease. Elevated ribonuclease activity thus represents a new biochemical marker relating to the genetic propensity of some strains of mice to die prematurely of spontaneous neoplasia.

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