Effect of norepinephrine and 5-hydroxytryptamine on the pulmonary circulation of the spinal dog

1959 ◽  
Vol 196 (5) ◽  
pp. 1045-1048 ◽  
Author(s):  
Gabriel G. Nahas ◽  
I. MacDonald
Keyword(s):  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Intact Animal ◽  
Pressure Change ◽  
Artery Pressure ◽  
Mean Pulmonary Artery Pressure ◽  
Similar Dose ◽  
Spinal Section ◽  
The Mean ◽  
The Right

One microgram of norepinephrine per kilogram of body weight injected in a 1-ml volume into the right atrium had little direct effect on the mean pulmonary artery pressure of dogs with intact nerve supply. The changes observed occurred simultaneously with systemic changes. In the spinal vagotomized dog, a similar dose produced a rise in mean pulmonary artery pressure which preceded any other pressure change. The isolated pulmonary hypertension produced in the intact animal by an identical dose of 5 HT is not modified after vagotomy or spinal section.

scholarly journals Pulmonary hemodynamics and diastolic function of right ventricle at isometric exercises in children with chronic bronchopulmonary pathology

2011 ◽  
Vol 10 (3) ◽  
pp. 105-110
Author(s):  
L. I. Agapitov ◽  
Yu. M. Belozerov ◽  
Yu. L. Mizernitsky ◽  
S. E. Tsyplenkova
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Diastolic Function ◽  
Pulmonary Artery Pressure ◽  
Isometric Exercise ◽  
Healthy Children ◽  
Pulmonary Hemodynamics ◽  
Artery Pressure ◽  
Mean Pulmonary Artery Pressure ◽  
The Right

We studied pulmonary hemodynamics and right ventricular diastolic function in 300 healthy children and 392 children with chronic bronchopulmonary pathology in an isometric exercise. Using echocardiography were determined systolic, diastolic, mean, pulmonary artery pressure, total pulmonary resistance, diastolic function of the right ventricle. Defined normal values of reactivity of pulmonary hemodynamics and diastolic function of the right ventricle in an isometric load. In patients with chronic bronchopulmonary pathology set higher increase of systolic, diastolic, mean, pulmonary artery pressure, decrease diastolic reserve the right ventricle compared to the control. The worst violations of pulmonary hemodynamics and diastolic function of the right ventricle during isometric load observed in patients with chronic Infectious-inflammatory and interstitial lung disease.

The protective effects of radiofrequency pulmonary artery denervation on the progression of chronic thromboembolic pulmonary hypertension

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
B Rudenko ◽  
D Feshchenko
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Control Group ◽  
Artery Pressure ◽  
Mean Pulmonary Artery Pressure ◽  
Thromboembolic Pulmonary Hypertension ◽  
The Mean

Abstract   This study aimed to assess the safety and efficacy of radiofrequency pulmonary artery denervation with the Simplicity system in patients with distal chronic thromboembolic pulmonary hypertension. Methods and results 60 chronic thromboembolic pulmonary hypertension patients with mean pulmonary artery pressure >25 mm Hg and absence of proximal artery lesion defined by pulmonary angiography were randomized into 2 groups. Group 1 included 30 patients who underwent pulmonary artery denervation procedure. The other 30 patients were assigned to the control group (only angio plus right heart catheterization). The procedure of pulmonary artery denervation was performed at the lateral wall of main pulmonary artery and ostium of the left and right pulmonary arteries using the electrode from Simplicity denervation system. The programmed ablation parameters were temperature >50°C and time = 120 s. Using the coronary guiding technique, the tip of electrode was applied at each spot rotating the tip with pace of 2 mm. The success was defined by decrease of mean pulmonary artery pressure >10%, absence of complications. The primary end point was comparison of mean pulmonary artery pressure change from baseline to 12 months in pulmonary artery denervation group compared with change from baseline to 12 months in control group. The secondary point was change in 6-min walk distance and pulmonary vascular resistance at the 12-month follow-up. There were no complications after pulmonary artery denervation. The hemodynamic success was achieved in 93% of all cases. The mean number of radiofrequency applications to achieve success was 10.3 per patient. During follow-up period 3 patients died in pulmonary artery denervation group: (1 died of gastro-intestinal bleeding, 2 – of right ventricular failure) and 3 patients in control group. The mean decreases in the mean pulmonary artery pressure were 8.7 mm Hg in the pulmonary artery denervation group and 3.1 mm Hg in control group (p<0.05). After pulmonary artery denervation in comparison with the control group was observed significant decrease in pulmonary vascular resistance (8.3±2.8 WU vs. 11.2±3.7). 6-min walk distance significantly increased by 81 m after pulmonary artery denervation and 29 m in control group (p<0.05). This improvement was associated with significant improvements in the WHO functional class. Conclusions The usage of the Simplicity denervation system in pulmonary artery denervation procedure is safe and effective. Further studies are required to determine the role of pulmonary artery denervation in the treatment of chronic thromboembolic pulmonary hypertension. The next step of pulmonary artery denervation development will be the use of this method combined with recommended treatment (medical therapy, pulmonary endarterectomy and balloon pulmonary angioplasty) as additional option, that may sufficiently improve outcomes in some patients Funding Acknowledgement Type of funding source: None

Pulmonary hypertension in sickle cell disease: cardiac catheterization results and survival

Blood ◽  
2003 ◽  
Vol 101 (4) ◽  
pp. 1257-1261 ◽  
Author(s):  
Oswaldo Castro ◽  
Mohammed Hoque ◽  
Bernice D. Brown
Keyword(s):  
Pulmonary Hypertension ◽  
Sickle Cell Disease ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Cardiac Catheterization ◽  
Sickle Cell ◽  
Cell Disease ◽  
Artery Pressure ◽  
Mean Pulmonary Artery Pressure ◽  
The Mean

Few results on cardiac catheterization have been published for patients with sickle cell disease (SCD) with pulmonary hypertension (PHTN). Their survival once this complication develops is unknown. We analyzed hemodynamic data in 34 adult patients with SCD at right-sided cardiac catheterization and determined the relationship of PHTN to patient survival. In 20 patients with PHTN the average systolic, diastolic, and mean pulmonary artery pressures were 54.3, 25.2, and 36.0 mm Hg, respectively. For 14 patients with SCD without PHTN these values were 30.3, 11.7, and 17.8 mm Hg, respectively. The mean pulmonary capillary wedge pressure in patients with PHTN was higher than that in patients without PHTN (16.0 versus 10.6 mm Hg;P = .0091) even though echocardiography showed normal left ventricular systolic function. Cardiac output was high (8.6 L/min) for both groups of patients. The median postcatheterization follow-up was 23 months for patients with PHTN and 45 months for those without PHTN. Eleven patients (55%) with PHTN died compared to 3 (21%) patients without PHTN (χ2 = 3.83;P = .0503). The mean pulmonary artery pressure had a significant inverse relationship with survival (Cox proportional hazards modeling). Each increase of 10 mm Hg in mean pulmonary artery pressure was associated with a 1.7-fold increase in the rate (hazards ratio) of death (95% CI = 1.1-2.7; P = .028). The median survival for patients with PHTN was 25.6 months, whereas for patients without PHTN the survival was still over 70% at the end of the 119-month observation period (P = .044, Breslow-Gehan log-rank test). Our findings suggest that PHTN in patients with SCD shortened their survival.

Đánh giá chỉ số áp lực động mạch phổi trên siêu âm tim qua thành ngực đối với bệnh nhân Covid-19

2022 ◽  
Author(s):  
Thanh Xuan Nguyen
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Pulmonary Artery ◽  
Arterial Hypertension ◽  
Pulmonary Artery Pressure ◽  
Severe Illness ◽  
Artery Pressure ◽  
Pulmonary Arterial ◽  
The Mean ◽  
The Right ◽  
D Dimer

TÓM TẮT Mục tiêu: Đánh giá áp lực động mạch phổi (ALĐMP) ở bệnh nhân Covid-19 mức độ trung bình và nặng. Đặc điểm lâm sàng, cận lâm sàng ở nhóm bệnh nhân Covid-19 mức độ trung bình và nặng có hoặc không có tăng ALĐMP. Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 200 bệnh nhân nhiễm SARS-CoV-2 đang được điều trị tại khu thoát hồi sức và khu nguy kịch trung tâm hồi sức tích cực người bệnh COVID-19 trực thuộc bệnh viện trung ương Huế tại thành phố Hồ Chí Minh từ ngày 12/8/2021 đến ngày 15/11/2021. Kết quả: Tuổi trung bình trong nhóm nghiên cứu là 57,38 ± 17,62 tuổi với 47,5% nam giới. Thời gian khởi bệnh là 6,92 ± 3,9 ngày. Qua đánh giá bằng siêu âm tim phát hiện có 28 (14%) bệnh nhân có biểu hiện tăng ALĐMP với độ tuổi trung bình là 67,04 ± 13,50 tuổi cao hơn so với nhóm không tăng ALĐMP 55,8 ± 17,75 tuổi và có các bệnh kèm theo thường xuyên hơn ĐTĐ (35,7%), THA (50%), BMV (6%), đồng thời chỉ số BMI cũng cao hơn 26,02 ± 3,68 kg/m2. Mức tăng ALDMP trung bình là 44,50 ± 8,19 mmHg, TAPSE ở bệnh nhân Tăng ALĐMP là 19,96 ± 2,36 mmHg thấp hơn ở bệnh nhân không tăng 25,51 ± 1,19 mmHg. Các đường kính đáy giữa và dọc của thất phải đều cao hơn đáng kể ở các bệnh nhân tăng ALĐMP, diện tích nhĩ phải cũng vậy 17,57 ± 2,23mm so với 13,33 ± 1,14mm ở bệnh nhân không có tăng ALĐMP. Tăng áp phổi ở các bệnh nhân đang điều trị Covid đa phần là ở mức độ nhẹ 85,7%, mức độ vừa và nặng chỉ chiếm tỷ lệ nhỏ 10,7% và 3,6%, chủ yếu ở khu vực bệnh nặng 78,6%, khu vực thoát hồi sức ít hơn chỉ có 21,4%. Bệnh nhân có tăng ALĐMP cho thấy có số lượng bạch cầu cao 16,21 ± 7,19 K/µL, D-Dimer cao 4508 ± 7208 ng/mL, Ferritin cao 1163 ± 738 ng/mL, CRP cao 111,4 ± 77,9 mg/L K/µL so với nhóm không có tăng ALĐMP. Kết luận: Siêu âm tim là phương pháp đơn giản, nhanh chóng giúp phát hiện, theo dõi và đánh giá tình trạng tăng áp phổi trong quá trình điều trị bệnh nhân COVID-19. ABSTRACT EVALUATION OF PULMONARY ARTERY PRESSURE INDEX ON ECHOCARDIOGRAPHY IN PATIENTS WITH COVID-19 Objectives: Evaluation of pulmonary artery pressure in moderate and severe Covid-19 patients. Clinical and subclinical characteristics in moderate and severe Covid-19 patients with or without pulmonary arterial hypertension. Methods: A cross - sectional descriptive study was performed on 200 Covid-19 patients who were treated in the recovery and critical areas of the COVID-19 Intensive care center of Hue Central Hospital in Ho Chi Minh City from August 12, 2021 to November 15, 2021. Results: The mean age in the study group was 57.38 ± 17.62. The time of onset was 6.92 ± 3.9 days. Underechocardiographic assessment, 28 (14%) patients showed an increase of PAP with an average age of 67.04 ± 13.50, which was higher than the group without an increase of PAP of 55.8 ± 17.75 and had comorbidities more often than diabetes (35.7%), hypertension (50%), CVD (6%), and BMI was also higher than 26.02 ± 3.68. The mean increase of PAP was 44.50 ± 8.19 mmHg, TAPSE in patients with increased PAP was 19.96 ± 2.36 lower than in patients without an increase of 25.51 ± 1.19. The medial and longitudinal basal diameters of the right ventricle were both significantly higher in patients with increased PAP, as was the area of the right atrium 17.57 ± 2.23 mm compared with 13.33 ± 1.14 mm in patients without increased PAP. Pulmonary arterial hypertension in COVID-19 patients is mostly mild at 85.7%, moderate and severe only account for a small proportion of 10.7% and 3.6%, mainly in severe illness areas. 78.6%, less in the recovery area with 21.4%. Patients with increased PAP showed a high white blood cell count of 16.21 ± 7.19 K/µL, a high D-Dimer 4508 ± 7208 ng/mL, a high Ferritin 1163 ± 738 ng/mL, a high CRP of 111.4 ± 77.9 ng/mL compared with the group without increased PAP. Conclusion: Echocardiography is a simple and quick modality to detect, monitor and evaluate pulmonary hypertension during the treatment of COVID-19 patients. Key words: SARS-CoV-2, COVID-19, Pulmonary arterial pressure.

scholarly journals Glenn procedure should be done as soon as possible and definitely before the mean Pulmonary artery pressure elevated

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Hadi Abo Aljadayel ◽  
Reza Abbaszadeh ◽  
Behrouz Azari ◽  
Mahmoud Meraji ◽  
Gholamreza Azari ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Artery Pressure ◽  
Mean Pulmonary Artery Pressure ◽  
The Mean ◽  
Glenn Procedure

Inflammation and Congenital Heart Disease Associated Pulmonary Hypertension

2015 ◽  
Vol 18 (1) ◽  
pp. 038 ◽  
Author(s):  
Mete Gursoy ◽  
Ece Salihoglu ◽  
Ali Can Hatemi ◽  
A. Faruk Hokenek ◽  
Suleyman Ozkan ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cell Distribution ◽  
Inflammation Markers ◽  
Distribution Width ◽  
Artery Pressure ◽  
Lymphocyte Ratio ◽  
Mean Pulmonary Artery Pressure ◽  
Pulmonary Arterial

<strong>Background:</strong> Increased blood flow may trigger pulmonary arterial wall inflammation, which may influence progression of pulmonary artery hypertension in patients with congenital heart disease. In this study, we aimed to investigate the correlation between preoperative inflammation markers and pulmonary arterial hypertension. <br /><strong>Methods:</strong> A total of 201 patients with pulmonary hypertension were enrolled in this study retrospectively; they had undergone open heart surgery between January 2012 and December 2013. Patients’ preoperative C-reactive protein (CRP), neutrophil to lymphocyte ratio, red blood cell distribution width, pulmonary pressures, and postoperative outcomes were evaluated.<br /><strong>Results:</strong> Patient age, neutrophil to lymphocyte ratio, red blood cell distribution width, and CRP were found to be significantly correlated with both preoperative peak and mean pulmonary artery pressures. These data were entered into a linear logistic regression analysis. Patient age, neutrophil to lymphocyte ratio, and CRP were found to be independently correlated with peak pulmonary pressure (P &lt; .001, P &lt; .001, and P = .004) and mean pulmonary artery pressure (P &lt; .001, P &lt; .001, and P = .001), whereas preoperative mean pulmonary artery pressure was found to be independently correlated with intensive care unit stay (P &lt; .001). No parameter was found to be significantly correlated with extubation time and mortality. Eighteen patients had experienced pulmonary hypertensive crisis; in this subgroup, patients’ mean pulmonary artery pressure and neutrophil to lymphocyte ratio were found to be significant (P = .047, P = .003). <br /><strong>Conclusion:</strong> Preoperative inflammation markers may be correlated with the progression of pulmonary hypertensive disease, but further studies with larger sample size are needed to determine the predictive role of these markers for postoperative outcomes.<br /><br />

Prognostic importance of mitral e′ velocity in constrictive pericarditis

2020 ◽  
Author(s):  
Jeong Hoon Yang ◽  
William R Miranda ◽  
Rick A Nishimura ◽  
Kevin L Greason ◽  
Hartzell V Schaff ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Constrictive Pericarditis ◽  
Multivariable Analysis ◽  
Artery Pressure ◽  
Myocardial Disease ◽  
Mean Pulmonary Artery Pressure ◽  
Diastolic Velocity ◽  
Long Term Mortality

Abstract Aims  Increased medial mitral annulus early diastolic velocity (e′) plays an important role in the echocardiographic diagnosis of constrictive pericarditis (CP) and mitral e′ velocity is also a marker of underlying myocardial disease. We assessed the prognostic implication of mitral e′ for long-term mortality after pericardiectomy in patients with CP. Methods and results  We studied 104 surgically confirmed CP patients who underwent echocardiography and cardiac catheterization within 7 days between 2005 and 2013. Patients were classified as primary CP (n = 45) or mixed CP (n = 59) based on the clinical history of concomitant myocardial disease. On multivariable analysis, medial e′ velocity and mean pulmonary artery pressure were independently associated with long-term mortality post-pericardiectomy. There were significant differences in survival rates among the groups divided by cut-off values of 9.0 cm/s and 29 mmHg for medial e′ and mean pulmonary artery pressure, respectively (both P &lt; 0.001). Ninety-two patients (88.5%) had elevated pulmonary artery wedge pressure (PAWP) (≥15 mmHg); there was no significant correlation between medial E/e′ and PAWP (r = 0.002, P = 0.998). However, despite the similar PAWP between primary CP and mixed CP groups (21.6 ± 5.4 vs. 21.2 ± 5.8, P = 0.774), all primary CP individuals with elevated PAWP had medial E/e′ &lt;15 as opposed to 34 patients (57.6%) in the mixed CP group (P &lt; 0.001). Conclusion  Increased mitral e′ velocity is associated with better outcomes in patients with CP. A paradoxical distribution of the relationship between E/e′ and PAWP is present in these patients but there is no direct inverse correlation between them.

scholarly journals Evaluation of the morphology and mechanics of the right ventricle using echocardiography before and after transcatheter balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
KIRILL Malikov ◽  
MARINA Kirichkova ◽  
MARIA Simakova ◽  
NARECK Marukyan ◽  
OLGA Moiseeva
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Pulmonary Artery Pressure ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Reverse Remodeling ◽  
Free Wall ◽  
Artery Pressure ◽  
Balloon Pulmonary Angioplasty ◽  
Before And After ◽  
The Right

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Chronic thromboembolic pulmonary hypertension (CTEPH) leads to a progressive increase in pulmonary vascular resistance (PVR) and pulmonary artery pressure (PAP) with the development of severe dysfunction of the right heart and heart failure. Mortality for three years with an average pressure in the pulmonary artery (PA) of more than 50 mmHg is more than 90%. Balloon pulmonary angioplasty (BPA) has a significant advantage over other methods of surgical treatment, but it requires the determination of additional non-invasive markers of effectiveness. Transthoracic echocardiography (TTE) remains the main method for assessing the morphology and function of the heart. Purpose Compare different indicators reflecting the severity of CTEPH with TTE indicators before and after BPA. To evaluate the effectiveness of using BPA for the treatment of patients with CTEPH using routine TTE and speckle tracking mode. Materials and methods For 18 months 30 patients without concomitant cardiovascular pathology were subjected to several BPA sessions. Before treatment, 50% of patients belonged to the 3 CTEPH functional class (FC), 40% to 2 FC, 10% to 1 FC. The average number of sessions was 4.7 ± 1.3. Before the first BPA and after the last, all the patients were performed: six-minute walk test (6MWT, metres), Borg scale (in points), test for NT-proBNP (pg/ml); TTE with assessment of the right ventricle (RV) and left ventricle (LV) including areas of the right atrium (aRA, cm2), mean pulmonary artery pressure (PUPM,mmHg),RV free wall strain (GLSFW, %), RV free wall strain rate (GLSRFW, sm/sec), RV free wall postsystolic shortening (PSSFW, %), tricuspid annular plane systolic excursion (TAPSE, sm), tricuspid annulus systolic velocity (TASV, sm/sec). Results. Before the first BPA session, the 6MWT in the patient group averaged 315.9 ± 9.08 metres, after - 439.5 ± 11.45 m; the Borg from 5.4 ± 0.94 points decreased to 4 ± 1.01 points; NT-proBNP before the treatment was 1513 ± 13.01 pg/ml, after - 171 ± 6.09; according to TTE the ratio of RV/ LV before and after treatment was 1.31 ± 0.02 and 0.97 ± 0.04; aRA was 29.3 ± 4.87 and 22.3 ± 3.53 cm2; basal RV - 52 ± 5.11 and 44 ± 7.26 mm; PUPM decreased from 76.6 ± 7.65 to 31.3 ± 3.78 mmHg; GLSFW from -14.69 ± 2.33 came to 17.5 ± 3.45 %; GLSRFW with -0.9 ± 0.09 to -1.7 ± 0.11 cm/sec; TAPSE from 16.7 ± 1.87 to 18.2 ± 2.34 cm; TASV from 10.11 ± 1.45 to 12.25 ± 1.98 cm/s, PSSFW before treatment was -18.4 ± 1.2%, after treatment in 66% of patients disappeared, in 34% became an average of 17.4 ± 0.9% The distribution of STEPH FC has also changed. Conclusion. BPA leads to an improvement in the tolerance of physical activity, clinical indicators, and parameters of central hemodynamics in the pulmonary circulation, evaluated according to direct manometry, and leads to reverse remodeling of the RV in the long term. Performing a staged BPA leads to an improvement in the functional parameters of contractility of the RV.

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