Blood flow and oxygen consumption of the pregnant uterus

1961 ◽  
Vol 200 (2) ◽  
pp. 274-278 ◽  
Author(s):  
William E. Huckabee ◽  
James Metcalfe ◽  
Harry Prystowsky ◽  
Donald H. Barron
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Early Pregnancy ◽  
Uterine Blood Flow ◽  
Pregnant Uterus ◽  
Gestational Period

The 4-aminoantipyrine method was employed for measuring rate of blood flow per kilogram of tissue in the pregnant uterus of anesthetized goats. A uterine vein was cannulated, but no other manipulation or disturbance of the uterus occurred. Uterine blood flow was high in the nonpregnant uterus and in early pregnancy but fell to a plateau of 277 ml/kg/min. at midpregnancy. (A-V)O2 was minimal in the first quarter of pregnancy and rose to a plateau also by midpregnancy. Rate of O2 consumption per kilogram was relatively high in the nonpregnant uterus, fell to a minimal value in the first quarter of the gestational period, and rose again to a plateau of 10.1 ml/kg/ min. beginning at midpregnancy. All these values appeared to remain unchanged during the last half of gestation.

Uterine blood flow and oxygen consumption in pregnant sheep and goats

1959 ◽  
Vol 197 (4) ◽  
pp. 929-934 ◽  
Author(s):  
James Metcalfe ◽  
Seymour L. Romney ◽  
Joseph R. Swartwout ◽  
Donald M. Pitcairn ◽  
Anton N. Lethin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Nitrous Oxide ◽  
Oxygen Consumption ◽  
Maternal Blood ◽  
Uterine Blood Flow ◽  
Human Beings ◽  
Pregnant Uterus ◽  
Fick Principle ◽  
Pregnant Sheep ◽  
Made In

This report deals with the volume of maternal blood flow to the pregnant uterus of the sheep and goat. Studies were made in 2 nonpregnant animals and in 20 pregnant animals at known stages of gestation. Measurements of uterine blood flow were made using nitrous oxide according to the Fick principle. The results indicate that in the nonpregnant uterus the blood flow is approximately 25 ml/min. It increases to approximately 200 ml/min. at the 80th day of gestation and exceeds 1000 ml/min. near the end of the 150-day gestation period of these animals. Data are also included for calculation of uterine O2 consumption. The findings with regard to uterine blood flow and O2 consumption are discussed in relation to previous findings in human beings and in rabbits.

P04.07: A prospective study of the effect of mifepristone on the uterine blood flow during early pregnancy

2004 ◽  
Vol 24 (3) ◽  
pp. 289-289
Author(s):  
C. F. Li ◽  
C. C. W. Chan ◽  
W. Cheung ◽  
W. W. K. So ◽  
P. C. Ho
Keyword(s):  
Blood Flow ◽  
Prospective Study ◽  
Early Pregnancy ◽  
Uterine Blood Flow ◽  
A Prospective Study

Effect of decreased uterine blood flow on uterine oxygen consumption in pregnant macaques

1968 ◽  
Vol 100 (6) ◽  
pp. 813-820 ◽  
Author(s):  
J.T. Parer ◽  
C.W. De Lannoy ◽  
A.S. Hoversland ◽  
J. Metcalfe
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Uterine Blood Flow

scholarly journals Relationship Between Prepregnancy and Early Pregnancy Uterine Blood Flow and Resistance Index

2009 ◽  
Vol 16 (11) ◽  
pp. 1091-1096 ◽  
Author(s):  
Sarah A. Hale ◽  
Adrienne Schonberg ◽  
Gary J. Badger ◽  
Ira M. Bernstein
Keyword(s):  
Blood Flow ◽  
Early Pregnancy ◽  
Resistance Index ◽  
Uterine Blood Flow

scholarly journals Effects of undernutrition and exercise during late pregnancy on uterine, fetal and uteroplacental metabolism in the ewe

1985 ◽  
Vol 53 (3) ◽  
pp. 625-635 ◽  
Author(s):  
K. D. Chandler ◽  
B. J Leury ◽  
A. R. Bird ◽  
A. W. Bell
Keyword(s):  
Blood Flow ◽  
Live Weight ◽  
Late Pregnancy ◽  
Uterine Blood Flow ◽  
Pregnant Uterus ◽  
Energy Demands ◽  
Umbilical Blood ◽  
Net Uptake ◽  
Chronic Undernutrition ◽  
Umbilical Blood Flow

1. Uterine, umbilical and, by difference, uteroplacental net uptakes of oxygen, glucose, lactate and 3-hydroxybutyrate (uterine uptake only) were measured in single-pregnant ewes which were either well-fed throughout, or severely undernourished for 8–20 d during late pregnancy. All animals were studied while standing at rest and then while walking on a treadmill at 0.7 m/s on a 10° slope for 60 min.2. Undernutrition did not significantly affect fetal or placental weights at 143 d gestation but caused a 14% decrease in maternal live weight. Uterine blood flow was decreased by 32% and was associated with a significant decrease in uteroplacental oxygen uptake; neither umbilical blood flow nor fetal O2, uptake were affected by maternal plane of nutrition. Maternal and fetal hypoglycaemia in underfed ewes was accompanied by 46–63 % decreases in uterine, umbilical and uteroplacental net uptakes of glucose, and similar declines in uterine and umbilical glucose/O, quotients. Moderate maternal hyperketonaemia was associated with 2.5-fold and 3-fold increases in uterine net uptake of 3-hydroxybutyrate and 3-hydroxybutyrate/O2 quotient respectively.3. Exercise caused significant decreases in uterine blood flow in fed and underfed ewes but did not affect uterine or umbilical O2 uptakes; uterine net glucose uptake increased in most ewes but umbilical uptake was not significantly affected. Umbilical net uptake of lactate was significantly reduced. In underfed ewes, the extent of hyperketonaemia was significantly reduced by exercise.4. Contrary to earlier proposals, the ovine pregnant uterus is sensitive and adaptable to long- and short-term alterations in maternal energy balance, as achieved by chronic undernutrition and exercise respectively. Thus, the fetus and placenta significantly add to, but do not necessarily have priority over the energy demands of other tissues of the ewe.

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