Effect of acetylcholine, atropine, and physostigmine on renal function in the dog

1964 ◽  
Vol 206 (3) ◽  
pp. 492-498 ◽  
Author(s):  
Arthur J. Vander
Keyword(s):  
Renal Artery ◽  
Renal Plasma Flow ◽  
Left Kidney ◽  
Urine Volume ◽  
Indirect Evidence ◽  
Urine Osmolality ◽  
Sodium Concentration ◽  
Sodium Reabsorption ◽  
Left Renal Artery ◽  
Parasympathetic Innervation

Acetylcholine (1–500 µg/min), atropine (.002–.12 mg/kg min), or physostigmine (.01–.08 mg/min) was infused directly into the left renal artery of anesthetized dogs, and right and left kidney functions were compared. Acetylcholine produced variable changes in glomerular filtration rate (–30 to +55%), but always increased renal plasma flow (4–115%), sodium excretion (20–365 µm/min), potassium excretion (1–56 µm/min), and urine volume (.25–3.1 ml/min). Filtration fraction, urine osmolality, and medullary sodium concentration were always reduced. These changes could all be reversed or prevented by atropine. Stop-flow studies failed to demonstrate any distal tubular inhibition of sodium reabsorption by acetylcholine. Neither atropine nor physostigmine, when infused into the renal artery by itself, produced any changes in renal hemodynamics or electrolyte excretion. These data demonstrate that acetylcholine can decrease renal arteriolar resistance and inhibit tubular sodium reabsorption. They also provide indirect evidence which supports, but does not prove, the hypothesis that the kidney lacks parasympathetic innervation.

Direct effects of endothelin in the rat kidney

1990 ◽  
Vol 258 (2) ◽  
pp. F397-F402 ◽  
Author(s):  
T. Katoh ◽  
H. Chang ◽  
S. Uchida ◽  
T. Okuda ◽  
K. Kurokawa
Keyword(s):  
Renal Artery ◽  
Rat Kidney ◽  
Renal Plasma Flow ◽  
Urine Volume ◽  
Fractional Excretion ◽  
Left Renal Artery ◽  
Dependent Manner ◽  
Direct Effects ◽  
Dose Dependent

In the present study, we tested the direct effects of endothelin (ET) on rat kidney in vivo. ET was infused into the left renal artery of anesthetized rats at a rate of 0.5, 5, 20, or 40 pmol/h. ET reduced ipsilateral urine volume (V), clearance of inulin (CIN), and clearance of p-aminohippuric acid (CPAH) in a dose-dependent manner. Thus ET at 20 pmol/h did not change V but decreased renal plasma flow (RPF) and glomerular filtration rate (GFR) by 27.6 +/- 14.3 and 30.8 +/- 10.4%, respectively, in the ipsilateral kidney. ET at 0.5 pmol/h was without effect and at 5 pmol/h had only minor effects on CIN and CPAH of ipsilateral kidney. At 40 pmol/h, ET reduced ipsilateral V, GFR, and RPF by 52.3 +/- 21.4, 58.4 +/- 14.5, and 72.5 +/- 10.6%, respectively. Filtration fraction and fractional excretion of Na remained unchanged during ET infusion. ET, 40 pmol/h, infused into the renal artery together with atrial natriuretic peptide (ANP) at a rate of 12 pmol/h reduced the ipsilateral V, GFR, and RPF by 33.2 +/- 6.3, 26.1 +/- 6.0, and 27.2 +/- 7.1%, respectively, decrements less than those with ET alone. When a calcium-channel blocker nicardipine was infused at a rate of 2.5 micrograms/h into the renal artery together with ET, 20 pmol/h, there was little change in the ipsilateral V, RPF, and GFR; ET, 40 pmol/h, with nicardipine did not change V and decreased GFR and RPF by 25.9 +/- 5.6 and 23.1 +/- 10.8%, respectively, decrements less than those without nicardipine.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute unilateral renal denervation in rats with extracellular volume expansion

1977 ◽  
Vol 232 (1) ◽  
pp. F26-F32 ◽  
Author(s):  
E. Bello-Reuss ◽  
E. Pastoriza-Munoz ◽  
R. E. Colindres
Keyword(s):  
Volume Expansion ◽  
Renal Denervation ◽  
Renal Plasma Flow ◽  
Left Kidney ◽  
Extracellular Volume ◽  
Urine Volume ◽  
Urinary Sodium Excretion ◽  
Sodium Reabsorption ◽  
Before And After ◽  
Extracellular Volume Expansion

Sodium reabsorption along the nephron was studied before and after acute unilateral denervation of the left kidney in anesthetized rats with extracellular volume expansion. Studies were also performed before and after sham denervation. Denervation increased urine volume (V) from the left kidney from 35.2 to 59.2 mul min-1 (P less than 0.001) and urinary sodium excretion (UNaV) from 6.9 to 11.8 mueq min-1 (P less than 0.001). The control right kidney showed a simultaneous 45% decrease in V and UNaV. Inulin clearance (GFR) and renal plasma flow (RPF) remained unchanged after denervation in both kidneys. Left kidney late proximal (F/P)m decreased from 1.50 to 1.24 (P less than 0.01); single-nephron GFR (SNGFR) remained unchanged. (F/P)m ratios were also decreased in early distal (3.87–2.65, P less than 0.005) and late distal (5.48–3.83, P less than 0.02) convolutions. Fractional and absolute Na reabsorption in the distal convolution did not decrease. GFR, RPF, V, UNa, late proximal (F/P)m, and SNGFR were unchanged in shamdenervated rats. The increases in V and UNa V produced by acute renal denervation in the volume-expanded anesthetized animal are thus caused by further depression of proximal tubular salt and water reabsorption.

Sodium and Water Excretion in Nephrotic Patients: Effects of Changes in Renal Haemodynamics

1990 ◽  
Vol 79 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Michael Allon ◽  
Charles B. Pasque ◽  
Mariano Rodriguez
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Urine Volume ◽  
Sodium Reabsorption ◽  
Plasma Volume Expansion ◽  
Water Excretion ◽  
Significant Change

1. Eight nephrotic patients were studied in order to evaluate the effects of acute changes in renal plasma flow and glomerular filtration rate on renal solute and water handling, in the absence of plasma volume expansion. 2. The subjects were studied first after the administration of captopril, a manoeuvre that increased renal plasma flow without a significant change in glomerular filtration rate, and a second time after receiving combined therapy with captopril and ibuprofen, a manoeuvre that decreased glomerular filtration rate without a significant change in renal plasma flow. 3. After captopril therapy, despite the increase in renal plasma flow, there was no significant change in proximal sodium reabsorption (as estimated from fractional lithium reabsorption), urine volume or urine osmolality. 4. The decrease in glomerular filtration rate observed after the administration of captopril plus ibuprofen was associated with decreases in fractional excretion of sodium and urine volume, and an increase in urine osmolality. The changes in these parameters of tubular function were proportionate to the changes in glomerular filtration rate. Fractional proximal sodium reabsorption increased substantially. 5. These observations suggest that, in the absence of plasma volume expansion, an increase in renal plasma flow does not increase sodium or water excretion by the nephrotic kidney. Moreover, during acute decreases in glomerular filtration rate, glomerulotubular balance appears to be disrupted, resulting in disproportionately high rates of proximal tubule sodium reabsorption.

Results of a three-year follow-up after endovascular therapy with multilayer flow modulator in complex thoracoabdominal aortic aneurysm: A case report

Vascular ◽  
2020 ◽  
pp. 170853812093351
Author(s):  
Nazım Kankılıç ◽  
Mehmet S Aydın
Keyword(s):  
Case Report ◽  
Aortic Aneurysm ◽  
Renal Artery ◽  
Medical Center ◽  
Left Kidney ◽  
Thoracoabdominal Aortic Aneurysm ◽  
Aortic Aneurysms ◽  
Left Renal Artery

Objectives Studies on the short-, medium and long-term effects of flow guiding stents are still limited. In this case report, we present three-year follow-up of the multilayer flow modulator stent in a 55-year-old patient with Crawford Type 2 thoracoabdominal aortic aneurysm. Methods A 55-year-old male patient with Crawford Type 2 thoracoabdominal aortic aneurysm had applied to our medical center. The aneurysm involved coeliac truncus and superior mesenteric artery and extended to the renal artery ostia. Multilayer flow modulator stent was successfully placed, and follow-up CT (Computed tomography) angiographic examination images recorded intermittently (36 months). Results After three years, it was observed that the left renal artery was thrombosed and the left kidney went to atrophy. Other major vascular branches were observed to be open. During this time, the aneurysm was completely closed with thrombus, but the diameter of the aneurysm continued to increase. Conclusions Multilayer flow modulator stents are safe in complex aortic aneurysms. The device increases the thrombus load in the aortic aneurysm and maintains the flow of the main vascular branches. But re-interventions, dilatation of the aneurysm sac and visceral branch obstructions are still challenging for multilayer flow modulator stents.

Prevention of two-kidney, one-clip renal hypertension in rat by ablation of AV3V tissue

1983 ◽  
Vol 245 (4) ◽  
pp. H683-H689 ◽  
Author(s):  
J. R. Haywood ◽  
G. D. Fink ◽  
J. Buggy ◽  
S. Boutelle ◽  
A. K. Johnson ◽  
...  
Keyword(s):  
Renal Artery ◽  
Third Ventricle ◽  
Renal Hypertension ◽  
Urine Volume ◽  
Urine Osmolality ◽  
Sham Operation ◽  
Vasopressin Release ◽  
Transient Rise ◽  
Fluid Regulation

This study examined the role of the anteroventral third ventricle (AV3V) in the renin-dependent two-kidney, one-clip model of renal hypertension. AV3V lesion and sham lesion rats were subjected to the placement of a clip on one renal artery or a sham operation. The sham lesion-renal artery clip rats experienced an increase in systolic blood pressure; however, AV3V lesioned animals experienced only a transient rise in arterial pressure during the 1st wk after clip. Body fluid regulation studies during the course of the hypertension revealed that there were no differences in water intake and urine volume between the lesion- and sham lesion-renal artery clip animals. Although significantly greater plasma and blood volumes were demonstrated in the AV3V lesion-sham clip rats compared with sham lesion animals, no differences in vascular volumes were detected in the renal artery clip rats. Finally, the rats were water deprived for 3 days to maximally stimulate vasopressin release. Urine osmolality increased significantly in all groups of rats except the AV3V lesion-renal artery clip animals protected against the hypertension.

scholarly journals Effect of sodium in a rehydration beverage when consumed as a fluid or meal

1998 ◽  
Vol 85 (4) ◽  
pp. 1329-1336 ◽  
Author(s):  
Melinda L. Ray ◽  
Mark W. Bryan ◽  
Timothy M. Ruden ◽  
Shawn M. Baier ◽  
Rick L. Sharp ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Plasma Volume ◽  
Urine Volume ◽  
Body Weight Loss ◽  
Urine Osmolality ◽  
Sodium Concentration ◽  
Fluid Composition ◽  
Liquid Meal ◽  
The Impact

To investigate the impact of fluid composition on rehydration effectiveness, 30 subjects (15 men and 15 women) were studied during 2 h of rehydration after a 2.5% body weight loss. In a randomized crossover design, subjects rehydrated with water (H2O), chicken broth (CB: 109.5 mmol/l Na, 25.3 mmol/l K), a carbohydrate-electrolyte drink (CE: 16.0 mmol/l Na, 3.3 mmol/l K), and chicken noodle soup (Soup: 333.8 mmol/l Na, 13.7 mmol/l K). Subjects ingested 175 ml at the start of rehydration and 20 min later; H2O was given every 20 min thereafter for a total volume equal to body weight loss during dehydration. At the end of the rehydration period, plasma volume was not significantly different from predehydration values in the CB (−1.6 ± 1.1%) and Soup (−1.4 ± 0.9%) trials. In contrast, plasma volume remained significantly ( P < 0.01) below predehydration values in the H2O (−5.6 ± 1.1%) and CE (−4.2 ± 1.0%) trials after the rehydration period. Urine volume was greater in the CE (310 ± 30 ml) than in the CB (188 ± 20 ml) trial. Urine osmolality was higher in the CB and Soup trials than in the CE trial. Urinary sodium concentration was higher in the Soup and CB trials than in the CE and H2O trials. These results provide evidence that the inclusion of sodium in rehydration beverages, as well as consumption of a sodium-containing liquid meal, increases fluid retention and improves plasma volume restoration.

Chemical Renal Medullectomy; Effect upon Reversal of Two-Kidney, One-Clip Hypertension in the Rat

1981 ◽  
Vol 61 (s7) ◽  
pp. 335s-338s ◽  
Author(s):  
R. F. Bing ◽  
G. I. Russell ◽  
J. D. Swales ◽  
H. Thurston ◽  
A. Fletcher
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Urine Volume ◽  
Renal Medulla ◽  
Plasma Renin ◽  
Left Renal Artery ◽  
Hypertensive Rats ◽  
Plasma Renin Concentration ◽  
Complete Reversal ◽  
Renal Artery Constriction

1. Chemical renal medullectomy was produced in rats by injection of 2-bromoethylamine hydrobromide. Plasma creatinine and blood pressure were unchanged although urine volume was increased fourfold. 2. Left renal artery constriction resulted in similar degrees of hypertension in both intact and medullectomized rats. This was associated with a significantly smaller rise in plasma renin concentration in the latter. 3. Blood pressure in conscious intact hypertensive rats became normal within 24 h of unclipping whereas blood pressure of medullectomized rats remained significantly elevated. 4. The presence of an intact renal medulla is essential to the complete reversal of two-kidney, one-clip hypertension in the rat. This may reflect the loss of a medullary vasodepressor system.

scholarly journals Renal artery stenosis of atherosclerotic etiology – the single kidney surgical recurrence 12 years after nephrectomy

2016 ◽  
Vol 63 (3) ◽  
pp. 251-254
Author(s):  
Maria Daniela Tănăsescu ◽  
◽  
Marcel Pălămar ◽  
Mihai Ovidiu Comşa ◽  
Alexandru Mincă ◽  
...  
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Left Kidney ◽  
Secondary Hypertension ◽  
Artery Stenosis ◽  
The Other ◽  
Left Renal Artery ◽  
Arterial Blood ◽  
The Moment ◽  
The Right

Objectives. Renal artery stenosis, as main cause of renovascular secondary hypertension, is mainly caused by atherosclerosis of large vessels and is clinically characterized by resistant or malignant hypertension, impacting the kidney function to various degrees. The present article brings into attention the case of a patient which developed renal artery stenosis on the left kidney, the same condition occurring 12 years later on the right kidney. Material and method. Our patient was initially diagnosed at the age of 48 with complete occlusion of the left renal artery, for which left nephrectomy was performed, while the right artery was normal. Twelve years later she presents with renal artery stenosis on the right kidney, which is treat by stent-angioplasty. Results. After surgery, the patient’s evolution was positive, with amelioration of the laboratory values, in parallel to the arterial blood pressure. Discussions. The probability that, in the moment of diagnosis of renal artery stenosis with progressive evolution to occlusion caused by atherosclerosis, the other artery would be normal, both seen by ultrasonography and angiography, while years later to develop stenosis, is minimal. Up to present, the literature holds little evidence of such similar cases. Conclusions. In the particular case of patients that were diagnosed with severe renal artery stenosis of atherosclerotic origin and had only one of the arteries affected, it is necessary to keep a permanent monitoring, justified by the risk of development of the same pathology to the other artery

Effect of cadmium on renal tubular sodium transport

1962 ◽  
Vol 203 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Arthur J. Vander
Keyword(s):  
Response Curve ◽  
Renal Cortex ◽  
Renal Plasma Flow ◽  
Peak Effect ◽  
Sodium Reabsorption ◽  
Plasma Sodium ◽  
Left Renal Artery ◽  
Anesthetized Dogs ◽  
Renal Tubular ◽  
The Right

The discovery of a cadmium-containing protein, metallothionein, in renal cortex prompted these experiments, performed on anesthetized dogs undergoing saline diuresis. Both ureters were catheterized, and standard clearance techniques were employed. After completion of at least three control clearance periods, cadmium (as CdCl2), 0.35–4.46 µm/kg, was infused i.v. over 10 min. Cysteine was also infused to prevent or minimize blood pressure, glomerular filtration rate (GFR), and renal plasma flow decreases induced by cadmium. After all 17 injections, sodium excretion decreased, (UNaV)cont – (UNaV)Cd = 46–275 µm/min. The dose-response curve appeared to be hyperbolic; peak effect was usually 30 min after injection; range was 15–50 min. There was no change in GFR during these same periods; the average GFR ratio (Cd/control) for all experiments was 1.01 ± 0.03. Plasma sodium also was unchanged. Direct left renal artery infusion of cadmium produced increased sodium reabsorption, either limited to the left or greater than that on the right. These experiments establish the ability of cadmium to increase tubular sodium reabsorption by a direct renal effect.

Permissive role of dopamine in renal action of ANP in volume-expanded rats

1989 ◽  
Vol 257 (2) ◽  
pp. F300-F309 ◽  
Author(s):  
T. Katoh ◽  
S. Sophasan ◽  
K. Kurokawa
Keyword(s):  
Renal Plasma Flow ◽  
Sch 23390 ◽  
Urine Volume ◽  
Fractional Excretion ◽  
Systemic Circulation ◽  
Left Renal Artery ◽  
Renal Effects ◽  
Renal Action ◽  
Permissive Role

A possible role of dopamine in the diuretic and natriuretic action of atrial natriuretic peptide (ANP) was evaluated in the rat. ANP was infused into the left renal artery of anesthetized rats whose kidneys were denervated. ANP both at 12 and 1.2 pmol/h caused immediate ipsilateral increases in urine volume (V), urine Na excretion (UNaV), and fractional excretion of Na (FENa). Ipsilateral glomerular filtration rate (GFR) and renal plasma flow (RPF) increased with 12 pmol/h ANP but not with 1.2 pmol/h ANP. Intravenous infusion of haloperidol, Sch-23390, or carbidopa markedly attenuated the increase in V, UNaV, and FENa with 12 pmol/h ANP and completely abolished the increases in GFR and RPF. Haloperidol, Sch-23390, and carbidopa also completely abolished the renal effects of 1.2 pmol/h ANP. In the presence of carbidopa, a small dose of dopamine infused into the systemic circulation, which by itself has no effects on blood pressure, V, GFR, RPF, and UNaV, restored the diuretic and natriuretic effects of ANP. In addition, an increase in urinary guanosine 3',5'-cyclic monophosphate by ANP was not affected by either haloperidol or carbidopa. These data indicate that dopamine may be necessary, as a permissive agent, for the renal effects of ANP to manifest and that the effects of dopamine may be independent of ANP-stimulated guanylate cyclase activation.

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