scholarly journals Childhood tolerance of severe influenza: a mortality analysis in mice

2017 ◽  
Vol 313 (6) ◽  
pp. L1087-L1095 ◽  
Author(s):  
Freeman Suber ◽  
Lester Kobzik
Keyword(s):  
Influenza A ◽  
Influenza Pandemic ◽  
Transcriptome Profiling ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Enhanced Resistance ◽  
Severe Influenza ◽  
1918 Influenza ◽  
Late Expression ◽  
Mortality Analysis

During the 1918 influenza pandemic, children experienced substantially lower mortality than adults, a striking but unexplained finding. Whether this was due to enhanced resistance (reduced virus load) or better tolerance (reduced impact of infection) has not been defined. We found that prepubertal mice infected with H1N1 influenza virus also showed greater survival than infected pubertal mice, despite similar virus loads. Transcriptome profiling of infected lungs identified estrogen as a regulator of susceptibility in both sexes and also linked better survival to late expression of IL-1β. Blocking puberty with gonadectomy or a gonadotropin-releasing hormone antagonist improved survival. Estrogen or testosterone (which can be converted to estrogen) restored susceptibility of gonadectomized pubertal mice to influenza mortality, but dihydrotestosterone (which cannot be converted to estrogen) did not. Estrogen receptor blockade with fulvestrant in both male and female pubertal mice resulted in improved survival, even when given 3 days after infection. Moreover, late, but not early, IL-1β neutralization after infection was also protective. These findings indicate that pubertal increases in estrogen in both sexes are associated with increased mortality during influenza. This helps explain the reduced mortality of children seen with influenza in 1918 and might also be relevant to childhood tolerance to many other infectious diseases.

The Osteopathic Approach During the 1918 Influenza Pandemic, Featuring Newly Analyzed Case Reports

2021 ◽  
Vol 31 (2) ◽  
pp. 9-16
Author(s):  
Leslie M. Ching ◽  
Ashley Watson ◽  
Tyler Watson ◽  
Philip Ridgway
Keyword(s):  
Mortality Rate ◽  
Influenza A ◽  
Case Reports ◽  
Influenza Pandemic ◽  
Geographic Location ◽  
H1n1 Influenza ◽  
Patient Treatment ◽  
Osteopathic Medicine ◽  
1918 Influenza ◽  
Osteopathic Physicians

Abstract Osteopathic physicians played a pivotal role in treating patients suffering from the H1N1 influenza A virus of the 1918 Influenza Pandemic. This article focuses on case reports and questionnaire answers from the Journal of the American Osteopathic Association (JAOA), now the Journal of Osteopathic Medicine (JOM), and Osteopathic Physician concerning the modalities, techniques, and efficacy of osteopathic treatments of the 1918 pandemic. There are 19,565 patients who are represented in this analysis. The results are compared to the often-cited 110,120 patient cases reported by the JOM in 1920. Several different approaches, including lymphatic and visceral techniques, were widely used at the time, and their historic incorporation into patient treatment is explored. There is a discussion of the geographic location and characteristics of the practices. Statistical breakdown of mortality rate, the most commonly used approaches, somatic dysfunctions commonly treated, physician anecdotes, and other common remedies used by osteopathic physicians, are noted additionally. A comparison is done of the literature regarding the osteopathic approach for COVID-19. The newly analyzed case reports in this article demonstrate a similar mortality rate as in the 1920 JAOA article and illustrate the geographical distribution, treatment approaches, and personal stories of osteopaths during the pandemic.

scholarly journals African Pentecostalism and the 1918 Influenza Pandemic: The Supernatural Amid the Fearful and Implications for the COVID-19 Pandemic

2020 ◽  
Vol 7 (5) ◽  
pp. 52-64
Author(s):  
Omololu Fagunwa
Keyword(s):  
Health Economic ◽  
Influenza Virus ◽  
Influenza Pandemic ◽  
H1n1 Influenza ◽  
Social Effects ◽  
Spiritual Awakening ◽  
H1n1 Influenza Virus ◽  
Good Opportunity ◽  
The Core ◽  
1918 Influenza

Infectious outbreaks that lead to epidemics and pandemics are dreaded because of the adverse health, economic, and social effects. The 1918 pandemic caused by the H1N1 influenza virus killed 40 million people worldwide. Like the case of COVID-19, the pandemic of 1918 kept Christians, as well as people of other faiths, from worshipping together. However, African indigenous Pentecostal movements and groups emerged in various part of the continent around the same time. This period was the time of huge Pneumatic experience and spiritual awakening.  The Pentecostals devoted themselves to building their faith and ceaseless prayer during that time, and this has become the foundation of the doctrine and theological instructions of most African Initiated Churches. Because are no studies that consider the 1918 flu pandemic and Pentecostal response in Africa, this study was undertaken. The time of the 1918 pandemic appeared to be a good opportunity for spiritual awakening. Intense prayer prevailed during those times and teaching and exposition about prayer formed the core of the theology of most African Initiated Churches. Pandemics often bring devastation but could also be an opportunity for spiritual awakening through prayer, love in action, social justice, compassion and care.

Prospective Evaluation of 2009 H1N1 Influenza A in Patients Admitted with Fever to an Oncology Unit

2011 ◽  
Vol 32 (8) ◽  
pp. 815-817 ◽  
Author(s):  
Karen Seiter ◽  
Dhaval Shah ◽  
Claudio Sandoval ◽  
Delong Liu ◽  
Robert B. Nadelman ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Infection Control ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Favorable Outcome ◽  
Prospective Evaluation ◽  
H1n1 Influenza Virus ◽  
Oncology Patients ◽  
2009 H1n1 ◽  
Oncology Unit

We prospectively evaluated all oncology inpatients for 2009 H1N1 influenza virus. All patients recovered completely. Evaluating all oncology patients with fever for influenza involved overtreatment of influenza-negative patients and involved a significant infection control burden. However, early antiviral intervention could have contributed to a favorable outcome.

scholarly journals Venovenous ECMO treatment, outcomes, and complications in adults according to large case series: A systematic review

2020 ◽  
pp. 039139882097540
Author(s):  
Jun Hyun Kim ◽  
Marina Pieri ◽  
Giovanni Landoni ◽  
Anna Mara Scandroglio ◽  
Maria Grazia Calabrò ◽  
...  
Keyword(s):  
Systematic Review ◽  
Treatment Outcomes ◽  
Influenza A ◽  
Influenza Pandemic ◽  
Case Series ◽  
H1n1 Influenza ◽  
Novel Coronavirus ◽  
Ecmo Treatment ◽  
Vv Ecmo ◽  
Large Case

Background: Venovenous extracorporeal membrane oxygenation (VV ECMO) has gained popularity for the treatment of refractory respiratory failure during and after the 2009 influenza pandemic, and still represents a precious therapeutic resource for severe novel coronavirus 2019 infection. However, most of the published studies are small case series, and only two randomized trials exist in literature. Aim: Aim of this systematic review is to describe trends in VV ECMO treatment outcomes according to large studies only. Methods: We searched and included studies with more than 100 VV ECMO cases dated up to August 1st, 2019. Results: Thirty-three studies published in the period 2011–2019 met inclusion criteria, for a total of 12,860 patients (age 46.3 ± 17.4 years). ARDS was mainly by pneumonia, in 3126 (37%) cases; further 401(7%) patients had H1N1 Influenza A infection. Cannulation-related complications occurred in 502 (7%) cases. Weighted mean (95% confidence interval) of VV ECMO duration was 8.9 (8.7–9.1) days, and ICU stay was 23.6 (22.4–24.8) days. Mortality at the longest follow up available was 40%. Data collection in 70% of the studies had a duration of >5 years. Conclusion: This study reveals the characteristics of large case VV ECMO studies.

scholarly journals Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Ignacio Mena ◽  
Martha I Nelson ◽  
Francisco Quezada-Monroy ◽  
Jayeeta Dutta ◽  
Refugio Cortes-Fernández ◽  
...  
Keyword(s):  
Influenza A ◽  
Influenza Pandemic ◽  
H1n1 Influenza ◽  
Central Mexico ◽  
Genome Sequences ◽  
Viral Reservoirs ◽  
Long Distance ◽  
Conflicting Evidence ◽  
2009 H1n1 ◽  
H1n1 Influenza Pandemic

Asia is considered an important source of influenza A virus (IAV) pandemics, owing to large, diverse viral reservoirs in poultry and swine. However, the zoonotic origins of the 2009 A/H1N1 influenza pandemic virus (pdmH1N1) remain unclear, due to conflicting evidence from swine and humans. There is strong evidence that the first human outbreak of pdmH1N1 occurred in Mexico in early 2009. However, no related swine viruses have been detected in Mexico or any part of the Americas, and to date the most closely related ancestor viruses were identified in Asian swine. Here, we use 58 new whole-genome sequences from IAVs collected in Mexican swine to establish that the swine virus responsible for the 2009 pandemic evolved in central Mexico. This finding highlights how the 2009 pandemic arose from a region not considered a pandemic risk, owing to an expansion of IAV diversity in swine resulting from long-distance live swine trade.

scholarly journals Contemporary Seasonal Influenza A (H1N1) Virus Infection Primes for a More Robust Response To Split Inactivated Pandemic Influenza A (H1N1) Virus Vaccination in Ferrets

2010 ◽  
Vol 17 (12) ◽  
pp. 1998-2006 ◽  
Author(s):  
Ali H. Ellebedy ◽  
Thomas P. Fabrizio ◽  
Ghazi Kayali ◽  
Thomas H. Oguin ◽  
Scott A. Brown ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Virus ◽  
H1n1 Influenza ◽  
Influenza Viruses ◽  
Inactivated Vaccine ◽  
H1n1 Influenza Virus ◽  
Influenza A H1n1

ABSTRACT Human influenza pandemics occur when influenza viruses to which the population has little or no immunity emerge and acquire the ability to achieve human-to-human transmission. In April 2009, cases of a novel H1N1 influenza virus in children in the southwestern United States were reported. It was retrospectively shown that these cases represented the spread of this virus from an ongoing outbreak in Mexico. The emergence of the pandemic led to a number of national vaccination programs. Surprisingly, early human clinical trial data have shown that a single dose of nonadjuvanted pandemic influenza A (H1N1) 2009 monovalent inactivated vaccine (pMIV) has led to a seroprotective response in a majority of individuals, despite earlier studies showing a lack of cross-reactivity between seasonal and pandemic H1N1 viruses. Here we show that previous exposure to a contemporary seasonal H1N1 influenza virus and to a lesser degree a seasonal influenza virus trivalent inactivated vaccine is able to prime for a higher antibody response after a subsequent dose of pMIV in ferrets. The more protective response was partially dependent on the presence of CD8+ cells. Two doses of pMIV were also able to induce a detectable antibody response that provided protection from subsequent challenge. These data show that previous infection with seasonal H1N1 influenza viruses likely explains the requirement for only a single dose of pMIV in adults and that vaccination campaigns with the current pandemic influenza vaccines should reduce viral burden and disease severity in humans.

scholarly journals Role of Sialic Acid Binding Specificity of the 1918 Influenza Virus Hemagglutinin Protein in Virulence and Pathogenesis for Mice

2009 ◽  
Vol 83 (8) ◽  
pp. 3754-3761 ◽  
Author(s):  
Li Qi ◽  
John C. Kash ◽  
Vivien G. Dugan ◽  
Ruixue Wang ◽  
Guozhong Jin ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Sialic Acid ◽  
Influenza A ◽  
Influenza Pandemic ◽  
Binding Specificity ◽  
Influenza Viruses ◽  
Virulence Determinants ◽  
Sialic Acid Binding ◽  
1918 Influenza

ABSTRACT The 1918 influenza pandemic caused more than 40 million deaths and likely resulted from the introduction and adaptation of a novel avian-like virus. Influenza A virus hemagglutinins are important in host switching and virulence. Avian-adapted influenza virus hemagglutinins bind sialic acid receptors linked via α2-3 glycosidic bonds, while human-adapted hemagglutinins bind α2-6 receptors. Sequence analysis of 1918 isolates showed hemagglutinin genes with α2-6 or mixed α2-6/α2-3 binding. To characterize the role of the sialic acid binding specificity of the 1918 hemagglutinin, we evaluated in mice chimeric influenza viruses expressing wild-type and mutant hemagglutinin genes from avian and 1918 strains with differing receptor specificities. Viruses expressing 1918 hemagglutinin possessing either α2-6, α2-3, or α2-3/α2-6 sialic acid specificity were fatal to mice, with similar pathology and cellular tropism. Changing α2-3 to α2-6 binding specificity did not increase the lethality of an avian-adapted hemagglutinin. Thus, the 1918 hemagglutinin contains murine virulence determinants independent of receptor binding specificity.

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