Sleep-promoting effects of endogenous pyrogen (interleukin-1)
1984 ◽
Vol 246
(6)
◽
pp. R994-R999
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Keyword(s):
When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.
1995 ◽
Vol 269
(5)
◽
pp. R1179-R1182
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1995 ◽
Vol 269
(6)
◽
pp. R1469-R1474
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1994 ◽
Vol 266
(5)
◽
pp. R1670-R1674
◽
1993 ◽
Vol 265
(5)
◽
pp. R1179-R1183
◽
Keyword(s):
1996 ◽
Vol 5
(3)
◽
pp. 183-187
◽
1990 ◽
Vol 27
(5)
◽
pp. 560-566
◽
1993 ◽
Vol 2
(3)
◽
pp. 117-120
◽
1996 ◽
Vol 81
(3)
◽
pp. 1312-1315
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Keyword(s):