scholarly journals Twelve-week combined resistance and aerobic training confers greater benefits than aerobic training alone in nondialysis CKD

2018 ◽  
Vol 314 (6) ◽  
pp. F1188-F1196 ◽  
Author(s):  
Emma L. Watson ◽  
Douglas W. Gould ◽  
Thomas J. Wilkinson ◽  
Soteris Xenophontos ◽  
Amy L. Clarke ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Estimated Glomerular Filtration Rate ◽  
Control Period ◽  
Knee Extensor ◽  
Quadriceps Muscle ◽  
Leg Extension ◽  
Knee Extensor Strength ◽  
Knee Extensor Muscle Strength

There is a growing consensus that patients with chronic kidney disease (CKD) should engage in regular exercise, but there is a lack of formal guidelines. In this report, we determined whether combined aerobic and resistance exercise would elicit superior physiological gains, in particular muscular strength, compared with aerobic training alone in nondialysis CKD. Nondialysis patients with CKD stages 3b–5 were randomly allocated to aerobic exercise {AE, n = 21; 9 men; median age 63 [interquartile range (IQR) 58–71] yr; median estimated glomerular filtration rate (eGFR) 24 (IQR 20–30) ml·min−1·1.73 m−2} or combined exercise [CE, n = 20, 9 men, median age 63 (IQR 51–69) yr, median eGFR 27 (IQR 22–32) ml·min−1·1.73 m−2], preceded by a 6-wk run-in control period. Patients then underwent 12 wk of supervised AE (treadmill, rowing, or cycling exercise) or CE training (as AE plus leg extension and leg press exercise) performed three times per week. Outcome assessments of knee extensor muscle strength, quadriceps muscle volume, exercise capacity, and central hemodynamics were performed at baseline, following the 6-wk control period, and at the end of the intervention. AE and CE resulted in significant increases in knee extensor strength of 16 ± 19% (mean ± SD; P = 0.001) and 48 ± 37% ( P < 0.001), respectively, which were greater after CE ( P = 0.02). AE and CE resulted in 5 ± 7% ( P = 0.04) and 9 ± 7% ( P < 0.001) increases in quadriceps volume, respectively ( P < 0.001), which were greater after CE ( P = 0.01). Both AE and CE increased distance walked in the incremental shuttle walk test [28 ± 44 m ( P = 0.01) and 32 ± 45 m ( P = 0.01), respectively]. In nondialysis CKD, the addition of resistance exercise to aerobic exercise confers greater increases in muscle mass and strength than aerobic exercise alone.

scholarly journals Creatine Kinase and Lactate Dehydrogenase Responses After Different Resistance and Aerobic Exercise Protocols

2017 ◽  
Vol 58 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Gustavo A. Callegari ◽  
Jefferson S. Novaes ◽  
Gabriel R. Neto ◽  
Ingrid Dias ◽  
Nuno D. Garrido ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Body Height ◽  
Blood Samples ◽  
Set Protocol ◽  
Experimental Protocols ◽  
Elevate Plasma

AbstractThe aim of this study was to investigate the responses of creatine kinase (CK) and lactate dehydrogenase (LDH) after performing different resistance and aerobic exercise protocols. Twelve recreationally trained men (age, 23.2 ± 5.6 years; body mass, 84.3 ± 9.3 kg; body height, 178.9 ± 4.5 cm; and BMI, 26.3 ± 2.3 kg·m2) volunteered to participate in this study. All subjects were randomly assigned to four experimental protocols (crossover): (a) aerobic training at 60% of VO2max, (b) aerobic training at 80% of VO2max, (c) a resistance exercise (RE) session with a bi-set protocol, and (d) an RE session with a multiple sets protocol. Blood samples were collected before, immediately after and 24 hours following the experimental protocols. After 24 hours, there was a significant increase in CK for the 80% of VO2max protocol vs. the bi-set RE session (p = 0.016). Immediately after the protocols, we observed a significant increase in LDH among certain groups compared to others, as follows: multiple sets RE session vs. 60% of VO2max, bi-set RE session vs. 60% of VO2max, multiple sets RE session vs. 80% of VO2max, and bi-set RE session vs. 80% of VO2max (p = 0.008, p = 0.013; p = 0.002, p = 0.004, respectively). In conclusion, aerobic exercise performed at 80% of VO2max appears to elevate plasma CK levels more than bi-set RE sessions. However, the bi-set and multiple sets RE sessions appeared to trigger greater levels of blood LDH compared to aerobic protocols performed at 60% and 80% of VO2max.

scholarly journals Conditioning Brain Responses to Improve Quadriceps Function in an Individual With Anterior Cruciate Ligament Reconstruction

2019 ◽  
Vol 11 (4) ◽  
pp. 306-315 ◽  
Author(s):  
Chandramouli Krishnan ◽  
Edward P. Washabaugh ◽  
Aviroop Dutt-Mazumder ◽  
Scott R. Brown ◽  
Edward M. Wojtys ◽  
...  
Keyword(s):  
Acl Reconstruction ◽  
Operant Conditioning ◽  
Muscle Activation ◽  
Cruciate Ligament ◽  
Knee Extensor ◽  
Quadriceps Muscle ◽  
Corticospinal Excitability ◽  
Knee Extensor Strength ◽  
Anterior Cruciate ◽  
Quadriceps Function

Background: Persistent quadriceps weakness and activation failure are common in individuals with anterior cruciate ligament (ACL) reconstruction. A growing body of evidence indicates that this chronic quadriceps dysfunction could be partly mediated due to reduced corticospinal excitability. However, current rehabilitation approaches do not directly target corticospinal deficits, which may be critical for restoring optimal clinical outcomes after the surgery. This case study tested the feasibility of operant conditioning of torque responses evoked by transcranial magnetic stimulation (TMS) to improve quadriceps function after ACL reconstruction. Hypothesis: Operant conditioning of motor evoked torque responses would improve quadriceps strength, voluntary activation, and corticospinal excitability. Study Design: Case study and research report. Level of Evidence: Level 5. Methods: A 24-year-old male with an ACL reconstruction (6 months postsurgery) trained for 20 sessions (2-3 times per week for 8 weeks) to increase his TMS-induced motor evoked torque response (MEP torque) of the quadriceps muscles using operant conditioning principles. Knee extensor strength, voluntary quadriceps muscle activation, and quadriceps corticospinal excitability were evaluated at 3 time points: preintervention (pre), 4 weeks (mid), and immediately after the intervention (post). Results: The participant was able to successfully condition (ie, increase) the quadriceps MEP torque after 1 training session, and the conditioned MEP torque gradually increased over the course of 20 training sessions to reach about 500% of the initial value at the end of training. The participant’s control MEP torque values and corticospinal excitability, which were measured outside of the conditioning paradigm, also increased with training. These changes were paralleled by improvements in knee extensor strength and voluntary quadriceps muscle activation. Conclusion: This study shows that operant conditioning of MEP torque is a feasible approach to improving quadriceps corticospinal excitability and quadriceps function after ACL reconstruction and encourages further testing in a larger cohort of ACL-reconstructed individuals. Clinical Relevance: Operant conditioning may serve as a potential therapeutic adjuvant for ACL rehabilitation.

scholarly journals Changes levels of myokines after aerobic training and resistance training in post-menopausal females with obesity

2020 ◽  
Author(s):  
Sunghwun Kang ◽  
Il Bong Park ◽  
Seung-Taek Lim
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Exercise Training ◽  
Physical Fitness ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Exercise Group ◽  
Muscle Endurance ◽  
Post Menopausal

Abstract Background To investigate changes in levels of myokines after regular aerobic training and resistance training in post- menopausal females with obesity. Methods Among 41 post- menopausal obese females volunteered to participate in this study performed regular physical exercise training (aerobic exercise and resistance exercise). These participants were randomly assigned to one aerobic exercise group (n = 21) and one resistance exercise group (n = 20). The experimental group performed three days of aerobic exercise and resistance exercise per week (i.e., Monday, Wednesday, and Friday) each group. Body composition, physical fitness, and myokines were measured at baseline, 6 weeks, and 12 weeks. Results Two-way within-factor ANOVA revealed group × time interaction for body mass index (BMI, p < 0.05). In the resistance exercise group, muscle endurance, power, and agility were significantly increased at 12 weeks than those at 6 weeks and baseline. In the aerobic exercise group, muscle strength, flexibility, muscle endurance, and agility were greater at 12 weeks than those at 6 weeks and baseline. Levels of IL-6, IL15, and BDNF were greater at 12 weeks than those at 6 weeks and baseline in both exercise groups. Conclusions Aerobic exercise training and resistance exercise training can change levels of myokines and improve body composition and physical fitness of obese females. These findings provide preliminary evidence that obese females need to exercise or perform physical activity to improve their levels of myokines and physical fitness.

scholarly journals Effect of Functional Progressive Resistance Exercise on Lower Extremity Structure, Muscle Tone, Dynamic Balance and Functional Ability in Children with Spastic Cerebral Palsy

Children ◽  
2020 ◽  
Vol 7 (8) ◽  
pp. 85
Author(s):  
Hye-Jin Cho ◽  
Byoung-Hee Lee
Keyword(s):  
Cerebral Palsy ◽  
Resistance Exercise ◽  
Functional Ability ◽  
Muscle Tone ◽  
Dynamic Balance ◽  
Group Interaction ◽  
Knee Extensor ◽  
Spastic Cerebral Palsy ◽  
Significant Time ◽  
Knee Extensor Strength

The purpose of this study was to investigate the effects of functional progressive resistance exercise (FPRE) on muscle tone, dynamic balance and functional ability in children with spastic cerebral palsy. Twenty-five subjects were randomized into two groups: the FPRE group (n = 13) and the control group (n = 12). The experimental group participated in an FPRE program for 30 min per day, three times per week for six weeks. Knee extensor strength, rehabilitative ultrasound imaging (RUSI), muscle tone, dynamic balance, and functional ability was evaluated. The results showed statistically significant time × group interaction effects on the dominant side for knee extensor strength and cross-sectional area (CSA) in RUSI (p < 0.05). On both sides for thickness of the quadriceps (TQ) in RUSI, muscle tone and dynamic balance were statistically significant time × group interaction effects (p < 0.05). Additionally, knee extensor strength, CSA, TQ in RUS, muscle tone, dynamic balance and gross motor function measure (GMFM) in functional ability were significantly increased between pre- and post-intervention within the FPRE group (p < 0.05). The results suggest that FPRE is both feasible and beneficial for improving muscle tone, dynamic balance and functional ability in children with spastic cerebral palsy.

No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise

2003 ◽  
Vol 285 (5) ◽  
pp. E1089-E1094 ◽  
Author(s):  
Magali Louis ◽  
Jacques R. Poortmans ◽  
Marc Francaux ◽  
Jacques Berré ◽  
Nathalie Boisseau ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Muscle Hypertrophy ◽  
Muscle Protein ◽  
Creatine Supplementation ◽  
Quadriceps Muscle ◽  
Anabolic Effect ◽  
Leg Extension ◽  
Sarcoplasmic Protein ◽  
Before And After ◽  
Total Creatine

Muscle hypertrophy during resistance training is reportedly increased by creatine supplementation. Having previously failed to find an anabolic effect on muscle protein turnover at rest, either fed or fasted, we have now examined the possibility of a stimulatory effect of creatine in conjunction with acute resistance exercise. Seven healthy men (body mass index, 23 ± 2 kg/m2, 21 ± 1 yr, means ± SE) performed 20 × 10 repetitions of leg extension-flexion at 75% one-repetition maximum in one leg, on two occasions, 4 wk apart, before and after ingesting 21 g/day creatine for 5 days. The subjects ate ∼21 g maltodextrin + 6 g protein/h for 3 h postexercise. We measured incorporation of [1-13C]leucine into quadriceps muscle proteins in the rested and exercised legs. Leg protein breakdown (as dilution of [2H5]phenylalanine) was also assessed in the exercised and rested leg postexercise. Creatine supplementation increased muscle total creatine by ∼21% ( P < 0.01). Exercise increased the synthetic rates of myofibrillar and sarcoplasmic proteins by two- to threefold ( P < 0.05), and leg phenylalanine balance became more positive, but creatine was without any anabolic effect.

Muscle quality. II. Effects of strength training in 65- to 75-yr-old men and women

1999 ◽  
Vol 86 (1) ◽  
pp. 195-201 ◽  
Author(s):  
B. L. Tracy ◽  
F. M. Ivey ◽  
D. Hurlbut ◽  
G. F. Martel ◽  
J. T. Lemmer ◽  
...  
Keyword(s):  
Strength Training ◽  
Older Women ◽  
Knee Extensor ◽  
Older Men ◽  
Quadriceps Muscle ◽  
Muscle Volume ◽  
Muscle Quality ◽  
Men And Women ◽  
Leg Extension ◽  
Before And After

To determine the effects of strength training (ST) on muscle quality (MQ, strength/muscle volume of the trained muscle group), 12 healthy older men (69 ± 3 yr, range 65–75 yr) and 11 healthy older women (68 ± 3 yr, range 65–73 yr) were studied before and after a unilateral leg ST program. After a warm-up set, four sets of heavy-resistance knee extensor ST exercise were performed 3 days/wk for 9 wk on the Keiser K-300 leg extension machine. The men exhibited greater absolute increases in the knee extension one-repetition maximum (1-RM) strength test (75 ± 2 and 94 ± 3 kg before and after training, respectively) and in quadriceps muscle volume measured by magnetic resonance imaging (1,753 ± 44 and 1,955 ± 43 cm3) than the women (42 ± 2 and 55 ± 3 kg for the 1-RM test and 1,125 ± 53 vs. 1,261 ± 65 cm3 for quadriceps muscle volume before and after training, respectively, in women; both P < 0.05). However, percent increases were similar for men and women in the 1-RM test (27 and 29% for men and women, respectively), muscle volume (12% for both), and MQ (14 and 16% for men and women, respectively). Significant increases in MQ were observed in both groups in the trained leg (both P < 0.05) and in the 1-RM test for the untrained leg (both P < 0.05), but no significant differences were observed between groups, suggesting neuromuscular adaptations in both gender groups. Thus, although older men appear to have a greater capacity for absolute strength and muscle mass gains than older women in response to ST, the relative contribution of neuromuscular and hypertrophic factors to the increase in strength appears to be similar between genders.

Home-Based Exercise With Blood Flow Restriction to Improve Quadriceps Muscle and Physical Function After Total Knee Arthroplasty: A Case Report

2019 ◽  
Vol 99 (11) ◽  
pp. 1495-1500 ◽  
Author(s):  
Matthew A Kilgas ◽  
Alicia E DenHerder ◽  
Lydia L M Lytle ◽  
Cameron T Williams ◽  
Steven J Elmer
Keyword(s):  
Blood Flow ◽  
Physical Function ◽  
Vastus Lateralis ◽  
Knee Extensor ◽  
Quadriceps Muscle ◽  
Flow Restriction ◽  
Home Based ◽  
Knee Extensor Strength ◽  
Long Term Follow Up ◽  
Total Knee

Abstract Background and Purpose After total knee arthroplasty (TKA), persistent quadriceps muscle atrophy and weakness impairs physical function. Blood flow restriction (BFR) exercise is emerging as a potential method to improve muscle size and strength in clinical populations with orthopedic limitations. There are no randomized controlled studies documenting BFR exercise after TKA. This case report describes the use of home-based BFR exercise to increase quadriceps size, strength, and physical function after TKA. Case Description A 59-year-old man (6 months post-TKA) performed body weight and walking exercises with BFR 5×/wk for 8 weeks. Blood flow in the TKA leg was restricted using a thigh cuff inflated to 50% of limb occlusion pressure. Lean leg mass, vastus lateralis thickness, knee extensor strength, and physical function were measured at baseline (6 months post-TKA), posttraining (8 months post-TKA), and long-term follow-up (14 months post-TKA). Outcomes After training, lean leg mass, vastus lateralis thickness, and knee extensor strength in the TKA leg increased by 4%, 14%, and 55%, respectively. Compared with baseline, posttraining knee extensor strength symmetry (TKA/uninvolved leg) increased from 64% to 98%. The patient’s performance improved for the 30-second chair stand, 40-m fast walk, and 6-minute walk tests. Increased quadriceps and physical function were maintained at the long-term follow-up. Discussion With enhanced quadriceps and physical function, the patient resumed independent physical activity. Muscle and strength gains surpassed those typically reported after TKA. Outcomes suggest that home-based BFR exercise was feasible, safe, and effective. BFR exercise after TKA is promising and warrants further research.

scholarly journals Changes levels of myokines after aerobic training and resistance training in post-menopausal females with obesity: a randomized controlled trial

2020 ◽  
Author(s):  
Sunghwun Kang ◽  
Il Bong Park ◽  
Seung-Taek Lim
Keyword(s):  
Exercise Training ◽  
Physical Fitness ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Controlled Trial ◽  
Exercise Group ◽  
Muscle Endurance ◽  
Randomized Controlled ◽  
Post Menopausal

Abstract Background To investigate changes in levels of myokines after regular aerobic training and resistance training in post- menopausal females with obesity. Methods A community-based a randomized controlled trial study was 41 post- menopausal females with obesity from Buk-gu community center, Chuncheon, Gangwon-do, Republic of Korea, from November 2017 until the end of October 2018. Among 41 post- menopausal obese females volunteered to participate in this study performed regular physical exercise training (aerobic exercise and resistance exercise). These participants were randomly assigned to one aerobic exercise group (n = 21) and one resistance exercise group (n = 20). The experimental group performed three days of aerobic exercise and resistance exercise per week (i.e., Monday, Wednesday, and Friday) each group. Body composition, physical fitness, and myokines were measured at baseline, 6 weeks, and 12 weeks. Results Two-way within-factor ANOVA revealed group × time interaction for body mass index (BMI, P < 0.05). In the resistance exercise group, muscle endurance (P < 0.001), power (P < 0.01), and agility (P < 0.001) were significantly increased at 12 weeks than those at 6 weeks and baseline. In the aerobic exercise group, muscle strength (P < 0.05), flexibility (P < 0.05), muscle endurance (P < 0.001), and agility (P < 0.001) were greater at 12 weeks than those at 6 weeks and baseline. Levels of IL-6 (P < 0.001), IL15 (P < 0.001), and BDNF (P < 0.001) were greater at 12 weeks than those at 6 weeks and baseline in both exercise groups. Conclusions Aerobic exercise training and resistance exercise training can change levels of myokines and improve body composition and physical fitness of obese females. These findings provide preliminary evidence that obese females need to exercise or perform physical activity to improve their levels of myokines and physical fitness.

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