Questioning the renoprotective role of L-type calcium channel blockers in chronic kidney disease using physiological modeling

2021 ◽  
Vol 321 (4) ◽  
pp. F548-F557
Author(s):  
Kyle H. Moore ◽  
John S. Clemmer
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Calcium Channel ◽  
Disease Progression ◽  
Physiological Model ◽  
Tubuloglomerular Feedback ◽  
Channel Blockers ◽  
Glomerular Injury ◽  
Kidney Disease Progression ◽  
Clinical Trial Results

Our physiological model replicates clinical trial results and provides unique insights into possible mechanisms that play a role in glomerular injury and hypertensive kidney disease progression during chronic calcium channel blocker (CCB) therapy. Specifically, these simulations predict the temporal changes in renal function with CCB treatment and demonstrate important roles for tubuloglomerular feedback and efferent arteriolar conductance in the control of chronic kidney disease progression.

scholarly journals Effectiveness of integrated care on delaying chronic kidney disease progression in rural communities of Thailand ( ESCORT ‐2) trials

Nephrology ◽  
2021 ◽  
Author(s):  
Teerawat Thanachayanont ◽  
Methee Chanpitakkul ◽  
Jukkapong Hengtrakulvenit ◽  
Podjanee Watcharakanon ◽  
Watcharapong Wisansak ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Rural Communities ◽  
Kidney Disease ◽  
Disease Progression ◽  
Integrated Care ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression

Impact of haemoglobin A1c trajectories on chronic kidney disease progression in type 2 diabetes

Nephrology ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1026-1032 ◽  
Author(s):  
Serena Low ◽  
Xiao Zhang ◽  
Jiexun Wang ◽  
Lee Y Yeoh ◽  
Yan L Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Haemoglobin A1c ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression

scholarly journals Burnt-Out Diabetes: Impact of Chronic Kidney Disease Progression on the Natural Course of Diabetes Mellitus

2009 ◽  
Vol 19 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Kamyar Kalantar-Zadeh ◽  
Stephen F. Derose ◽  
Susan Nicholas ◽  
Deborah Benner ◽  
Kumar Sharma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Natural Course ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression
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