Restoration of volume-pressure curves with a lecithin fog

1970 ◽  
Vol 28 (4) ◽  
pp. 470-473 ◽  
Author(s):  
D. C. Shannon ◽  
H. Kazemi ◽  
E. W. Merrill ◽  
K. A. Smith ◽  
P. S. Wong
Keyword(s):  
Volume Pressure Curves

Influence of starvation on the lung: effect on glucose and palmitate utilization

1975 ◽  
Vol 38 (3) ◽  
pp. 513-516 ◽  
Author(s):  
R. A. Rhoades
Keyword(s):  
Fatty Acid ◽  
Phospholipid Fatty Acid ◽  
Phospholipid Fatty Acid Composition ◽  
Glycerol Phosphate ◽  
Glucose Incorporation ◽  
Ad Libitum ◽  
Physiologic State ◽  
Relative Utilization ◽  
Volume Pressure Curves ◽  
Palmitate Metabolism

The relative utilization of [U-14C]glucose and [1–14C]palmitate was examined in lung slices of male Long Evans hooded rats fed ad libitum and starved for 72 h. Food deprivation (72-h fast) significantly decreased [U-14C]flucose oxidation and incorporation into lung lipids. Glucose incorporation into phospholipid-fatty acid (53%) was, in proportion, more markedly reduced than into phospholipid-gluceride glycerol (33%), suggesting that glucose was being conserved for the formation of alpha-glycerol phosphate. (1–14C) palmitate utilization following fasting showed a significant 40% increase in oxidation, and a significant 16% increase in phospholipids, indicating preferential utilization of fatty acids over glucose. Phospholipid fatty acid composition, surface tension measurements and volume-pressure curves were not affected by fasting. Khe data indicate that glucose and palmitate metabolism are interrelated, and that the relative utilization of these substrates is changed to maintain essential lung lipids during an altered physiologic state.

Static volume-pressure curves of dog lungs--in vivo and in vitro.

1968 ◽  
Vol 24 (3) ◽  
pp. 348-354 ◽  
Author(s):  
M E Wohl ◽  
J Turner ◽  
J Mead
Keyword(s):  
Volume Pressure Curves

STATIC VOLUME–PRESSURE RELATIONS IN GUINEA PIG LUNGS AFTER INHALATION OF ALUMINUM OR IRON OXIDE PARTICLES AND BRONCHODILATOR AEROSOLS

1963 ◽  
Vol 41 (2) ◽  
pp. 461-468 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Iron Oxide ◽  
Guinea Pig ◽  
Aluminum Oxide ◽  
Previous Exposure ◽  
Iron Oxide Particles ◽  
Antagonistic Action ◽  
Low Concentration ◽  
Oxide Particles ◽  
The Right ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic guinea pig lungs under normal controlled conditions are compared with those obtained from animals having inhaled fine aluminum or iron oxide particles. After particles inhalation, the inflation curves are deviated to the right, showing a constricting effect. Previous exposure to low concentration of isoproterenol aerosol fails to reverse completely the constricting effect induced by a prior inhalation of aluminum oxide particles although in combination with diphenhydramine or at a higher concentration an antagonistic action appears. Cyproheptadine aerosolation also prevents the constricting effect of inhaled aluminum oxide particles The constricting effect of iron oxide was not prevented by those dilating aerosols at concentrations used.

PRESSURE–VOLUME CURVES IN ISOLATED ATELECTATIC RAT LUNGS AFTER ALUMINUM OXIDE MICROPARTICLE INHALATION

1963 ◽  
Vol 41 (1) ◽  
pp. 1257-1265 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Guinea Pig ◽  
Aluminum Oxide ◽  
Normal Control ◽  
Oxide Particle ◽  
Aluminum Particles ◽  
Aluminum Oxide Particle ◽  
Rat Lungs ◽  
Particle Inhalation ◽  
Oxide Particles ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic rat lungs under normal control conditions were compared with those obtained from lungs of animals previously exposed to inhalation of submicronic aluminum oxide particles for various periods of time. A dilating effect was recorded in rat lungs after aluminum oxide particle inhalation contrasting with the constricting effect reported by many authors in guinea pig, dog, cat, and man. Inhalation of fine aluminum particles before or after inhalation of sympathomimetic aerosol resulted in a more intense dilatation. The constricting effect of carbachol was antagonized by prior inhalation of fine aluminum oxide dust and enhanced when the order of inhalations was reversed.

Static features of the passive rib cage and abdomen-diaphragm

1965 ◽  
Vol 20 (6) ◽  
pp. 1187-1193 ◽  
Author(s):  
Emilio Agostoni ◽  
Piero Mognoni ◽  
Giorgio Torri ◽  
Ada Ferrario Agostoni
Keyword(s):  
Chest Wall ◽  
Lung Volume ◽  
Vital Capacity ◽  
Small Volume ◽  
Respiratory Muscles ◽  
Muscular Activity ◽  
Pressure Curve ◽  
Rib Cage ◽  
Expiratory Muscles ◽  
Volume Pressure Curves

The static relation between lung volume and rib cage circumference has been determined over the vital capacity range, during relaxation and activity of the respiratory muscles with open airway. At small volume the circumference is larger during relaxation; the reverse occurs at large volume. During relaxation at full expiration the cross section of the rib cage becomes more elliptical and in some subjects also greater. Hence the shape of the chest wall during muscular activity is different from that during relaxation. Because of this change of chest wall shape the outward recoil of the passive rib cage at full expiration, in the seven subjects examined, is higher than that given by the conventional volume-pressure curve during relaxation. The volume displacements of the rib cage and of the abdomen-diaphragm have been calculated and the volume-pressure curves of the passive rib cage and abdomen-diaphragm have been constructed, taking into account the changes of the chest wall shape occurring during relaxation. change of chest wall shape during relaxation; relation between lung volume and rib cage circumference during relaxation; relation between pleural pressure and rib cage circumference during relaxation; recoil of the passive rib cage; pressure exerted by the expiratory muscles at full expiration; volume-pressure curve of the passive rib cage; volume-pressure curve of the passive abdomen-diaphragm Submitted on September 14, 1964

Static volume-pressure interrelations of the lungs and pulmonary blood vessels in excised cats' lungs

1959 ◽  
Vol 14 (2) ◽  
pp. 167-173 ◽  
Author(s):  
N. Robert Frank ◽  
Edward P. Radford ◽  
James L. Whittenberger
Keyword(s):  
Blood Vessels ◽  
Technical Assistance ◽  
Vascular System ◽  
Surface Forces ◽  
Elastic Behavior ◽  
Pressure Curve ◽  
Complex Mechanism ◽  
Vascular Volume ◽  
Equilibrium Volume ◽  
Volume Pressure Curves

Measurements were made of the effect of pulmonary vascular distention on static volume-pressure relations of excised cats' lungs filled either with saline to minimize surface forces, or inflated with gas. Only slight changes of questionable significance occurred in elastic behavior of the lungs during deflation when pulmonary vascular pressure was increased from 0 to 16 cm H2O. Measurements were also made of quasi-static pulmonary vascular volume-pressure relations at different lung volumes. The overall slope of the vascular volume-pressure curve in saline-filled lungs was greatest at a moderate lung volume and was slightly less when the lungs were either collapsed or highly distended. The vascular volume-pressure curve was considerably flattened in gas-inflated lungs at airway pressures above 10 cm H2O. During filling and emptying of the vascular system there were slight but definite changes in equilibrium volume of the lung. Hysteresis of the vascular system was an invariable finding. Regardless of the complex mechanism underlying hysteresis, it can be explained if all units of the system are assumed to have sigmoid volume-pressure curves. The findings of these experiments illustrate the highly complex interrelations of the pulmonary blood vessels and lungs, particularly when surface forces are taken into account. Note: (With the Technical Assistance of Martha McLaughlin) Submitted on May 29, 1958

scholarly journals Volume-Pressure Curves of the Human Arm

1957 ◽  
Vol 5 (3) ◽  
pp. 236-239 ◽  
Author(s):  
A. LANARI ◽  
B. BROMBERGER-BARNEA ◽  
A. LAMBERTINI
Keyword(s):  
Human Arm ◽  
Volume Pressure Curves

PRESSURE–VOLUME CURVES IN ISOLATED ATELECTATIC RAT LUNGS AFTER ALUMINUM OXIDE MICROPARTICLE INHALATION

1963 ◽  
Vol 41 (5) ◽  
pp. 1257-1265 ◽  
Author(s):  
E. Robillard ◽  
Y. Alarie
Keyword(s):  
Guinea Pig ◽  
Aluminum Oxide ◽  
Normal Control ◽  
Oxide Particle ◽  
Aluminum Particles ◽  
Aluminum Oxide Particle ◽  
Rat Lungs ◽  
Particle Inhalation ◽  
Oxide Particles ◽  
Volume Pressure Curves

Volume–pressure curves obtained from isolated atelectatic rat lungs under normal control conditions were compared with those obtained from lungs of animals previously exposed to inhalation of submicronic aluminum oxide particles for various periods of time. A dilating effect was recorded in rat lungs after aluminum oxide particle inhalation contrasting with the constricting effect reported by many authors in guinea pig, dog, cat, and man. Inhalation of fine aluminum particles before or after inhalation of sympathomimetic aerosol resulted in a more intense dilatation. The constricting effect of carbachol was antagonized by prior inhalation of fine aluminum oxide dust and enhanced when the order of inhalations was reversed.

Effects of hypoxia and histamine infusion on lung blood volume

1975 ◽  
Vol 38 (5) ◽  
pp. 811-816 ◽  
Author(s):  
C. A. Dawson ◽  
T. E. Forrester ◽  
L. H. Hamilton
Keyword(s):  
Indocyanine Green ◽  
Vascular Permeability ◽  
Blood Volume ◽  
Perfusion Pressure ◽  
Perfusion System ◽  
Fluid Content ◽  
Venous Volume ◽  
Lung Preparation ◽  
Volume Pressure Curves ◽  
Total Fluid

Using an isolated perfused cat lung preparation we examined the effects of hypoxia and histamine infusion on the lung blood volume. Total lung blood volume was determined from the indocyanine green transit time and the ether bolus technique was used to estimate arterial and venous volumes during forward and retrograde perfusion, respectively. Changes in lung total fluid content were determined from changes in the blood volume of the perfusion system. Hypoxia increased perfusion pressure and decreased total fluid and blood volume. Histamine infusion also increased perfusion pressure and decreased blood volume. However, histamine increased total fluid volume, indicating an increase in vascular permeability. Hypoxia decreased arterial and venous volumes, and histamine decreased venous volume. The slopes of the arterial and venous volume/pressure curves were not altered by hypoxia or histamine.

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