Effect of high fluid intake on the renal concentrating mechanism of normal man.

1974 ◽  
Vol 36 (4) ◽  
pp. 434-439 ◽  
Author(s):  
C A Vaamonde ◽  
J I Presser ◽  
W Clapp
1975 ◽  
Vol 228 (3) ◽  
pp. 909-914 ◽  
Author(s):  
RK Webb ◽  
PB Woodhall ◽  
CC Tisher ◽  
RR Robinson

Although chronic lithium therapy has been associated with a defect in the urinary concentrating mechanism, short-term renal effects of lithium have received little attention in the intact animal. Solute-free water reabsorption (T-cH2O) and free water clearance (CH2O) were measured in primates of the genus Galago under control conditions and while animals were receiving either 0.5 mmol/kg-h or 1.0 mmol/kg-h lithium chloride (135 mM) intravenously. CH2O was unchanged by lithium infusion (P greater than 0.10), whereas T-cH2O was significantly depressed at all levels of osmolal clearance (P smaller than 0.01). Spontaneous recovery of near-normal T-cH2O was documented in two animals within 1 wk following acute lithium infusion. In addition it was observed that lithium-induced depression of T-cH2O could be partially prevented by pretreatment with intravenous amiloride. These results suggest that alterations in the renal concentrating mechanism can occur rapidly following the onset of lithium administration. They also imply that impairment of the renal concentrating mechanism by lithium is due at least in part to antagonism of the action of vasopressin on the collecting duct.


2005 ◽  
Vol 42 (5) ◽  
pp. 557-563 ◽  
Author(s):  
Kikuo Okamura ◽  
Yukihiko Washimi ◽  
Hidetoshi Endo ◽  
Haruhiko Tokuda ◽  
Yukio Shiga ◽  
...  

1998 ◽  
Vol 36 (1-2) ◽  
pp. 27-29 ◽  
Author(s):  
Yoshito Kamijo ◽  
Kazui Soma ◽  
Yasushi Asari ◽  
Takashi Ohwada

2018 ◽  
Vol 4 (1) ◽  
pp. e000351 ◽  
Author(s):  
Juan Pablo Martinez-Cano ◽  
Valeria Cortes-Castillo ◽  
Juliana Martinez-Villa ◽  
Juan Carlos Ramos ◽  
Juan Pablo Uribe

BackgroundDysnatremia has been associated with sports activity, especially long-distance running and endurance sports. High fluid intake is associated with hyponatremia. This study aims to evaluate dysnatremia and risk factors in half-marathon runners under warm and humid environmental conditions. MethodsA cross-sectional study was performed among randomly selected runners in the 2017 Cali half marathon. Runners on diuretic therapy or with a known history of kidney disease were excluded. Participants went through a 2-day assessment. Previous medical history, training history, body mass index and running history were determined in the first assessment. Symptoms of dysnatremia and level of fluid consumption during the race were registered during the second assessment and post-run blood sampling for serum [Na+] was also undertaken. Results130 runners were included in the study. The complete 2-day assessment was performed on 81 participants (62%) that were included in the final analysis. No cases of hyponatremia were found; instead, there were six cases of asymptomatic hypernatremia (7.4%). This hypernatremia had a statistically significant association with lower frequency (p=0.01) and volume of fluid intake during the race (water: p=0.02, Gatorade: p=0.04). ConclusionHyponatremia has been associated with high fluid intake in races performed under cool weather, such as the Boston Marathon during spring. In contrast, hypernatremia was found in a half marathon in warm and humid weather, which was associated with lower volume and frequency of fluid intake, suggesting that under warm and humid conditions, a median fluid intake of 900 mL during the race could prevent this event.


1959 ◽  
Vol 38 (10 Pt 1-2) ◽  
pp. 1725-1732 ◽  
Author(s):  
Lawrence G. Raisz ◽  
William Y. W. Au ◽  
Robert L. Scheer

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